Clinical trials: Experimental
Personality Disorder, Borderline, Personality Trait
Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).
Study background: Specialized Group Outpatient Clinic within specialist mental health services, tailoring two year group treatment programmes for severe Avoidant PD (AvPD) and Borderline PD (BPD) with Affect Consciousness (AC)…
- Conditions
- Personality Disorder, Borderline, Personality Trait, Personality Disorder, Personality Type
- Trial name
- NCT06983002
- Testing
- Experimental group: AC-group therapy intervention., Control group 1: Body Awareness Group., Control group 2: Art Psychotherapy group.
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Helse Stavanger HF
Pain, Dentin Sensitivity
Effect of an Experimental Gel Containing Copaiba Oil-resin in the Control of Dentin Hypersensitivity
This randomized, single-blind, placebo-controlled clinical trial aims to clinically evaluate the effect of an experimental gel containing copaiba oleo-resin in the control of dentin hypersensitivity (DH) in non-carious cervical…
- Conditions
- Pain, Dentin Sensitivity, Dentin Desensitizing Agents
- Trial name
- NCT06872749
- Testing
- KF2 (Potassium nitrate gel), experimental Copaiba gel
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Chronic Venous Insufficiency
Long-term Effects of Inspiratory Muscle Training in Chronic Venous Insufficiency
The long-term effectiveness of inspiratory muscle training, which is known in the literature to help venous return by increasing the pump effect of the diaphragm muscle, remains unclear in individuals with chronic venous…
- Trial name
- NCT05982405
- Testing
- Training group: Inspiratory muscle training, Control group: Thoracic expansion exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Democracy University
Vestibular Schwannoma, Unilateral Vestibular Deficit
Early Rehabilitation Using Head Impulse Test for Acute Vestibular Deficit
The vestibulo-ocular reflex (VOR) induces a compensatory movement in the eye when the head is rotated, to maintain stable vision when we move. It originates in the peripheral vestibular system, which detects head movements.
- Trial name
- KINE HIT (NCT06660082)
- Testing
- Experimental treatment: Head movements
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Cancer, Relapsed/Refractory Large B-cell Lymphoma (LBCL)
A Phase 2 Study of Firi-cel in Patients With Relapsed/Refractory Large B-cell Lymphoma
This is a prospective, open-label, multi-center clinical study designed to evaluate the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of firicabtagene autoleucel (firi-cel), a…
- Trial name
- FIRCE-1 (NCT05972720)
- Testing
- Fludarabine (Conditional therapy), Cyclophosphamide Monohydrate (Conditional therapy), firi-cel (Experimental drug)
- Where
- 31 sites in United States
- Volunteers
- 101 people
- Sponsor
- CARGO Therapeutics
Autism, Autism Spectrum Disorder
Social Robotics for Autism
Socio-pragmatics focuses on the study of language in the context of social interactions. It explores how individuals use language to communicate effectively in specific social situations, taking into consideration the social…
- Trial name
- SRI (NCT06974240)
- Testing
- Experimental Group, control group
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Suicide, Suicide Threat
Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department
Current treatment for acutely suicidal patients are limited to hospitalization, psychotherapy, electro-convulsant therapy, or a combination of the aforementioned. However, this has added to the national boarding problem.
- Conditions
- Suicide, Suicide Threat, Depression Severe
- Trial name
- NCT04260607
- Testing
- Ketamine Hydrochloride, Normal saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Naval Medical Center Camp Lejeune
Spastic Diplegia Cerebral Palsy, Quality of Lifte
Additional Effects of Cuevas Medek Exercises Along With Conventional Physical Therapy on Gross Motor Proficiency and Quality of Life, in Children With Spastic Diplegic Cerebral Palsy
Cerebral palsy (CP) is a prevalent pediatric neurological disorder hindering movement and posture development due to non-progressive disruptions in brain development.
- Conditions
- Spastic Diplegia Cerebral Palsy, Quality of Lifte, Motor Function
- Trial name
- NCT06966609
- Testing
- Control Group, Experimental Group
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Foundation University Islamabad
ICU Patients Under Invasive Mechanical Ventilation
Preoxygenation for Tracheal Aspirations in Intensive Care
Clearing the airways is a complex phenomenon involving the production of secretions, the nature of mucus (viscosity, elasticity, stringiness, and adhesiveness), ciliary movement, and coughing.
- Trial name
- POXTRA (NCT06421012)
- Testing
- Experimental : Patients without additional preoxygenation, Active Comparator : Patients with additional preoxygenation
- Where
- France
- Volunteers
- 2,260 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Photodynamic Therapy, Third Molar Extraction
The Effect of Photodynamic Therapy on Post-extraction Third Molar
The extraction of lower third molars is one of the most frequent procedures in oral surgery. For this reason, the extraction of these teeth generally requires a surgical approach involving the elevation of a mucoperiosteal flap…
- Conditions
- Photodynamic Therapy, Third Molar Extraction, Antimicrobial Photodynamic Therapy
- Trial name
- NCT06964178
- Testing
- Experimental: antimicrobial photodynamic therapy (aPDT) after extraction of third molar
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Surgery, Perioperative Medicine
Personalized Perioperative Care Based on Patient Reported Outcomes Measures
In the perioperative setting, Patient Reported Outcomes Measures (PROMs) are important for both patients and clinicians. Reliable PROMs, like the Quality Of Recovery 15 (QoR-15) questionnaire, are available for patients…
- Trial name
- SUPPORT (NCT06182254)
- Testing
- Experimental group: OPTIMISTIC follow-up, Control group: Usual conventional follow-up
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Strasbourg, France
Tooth Erosion
An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared…
- Trial name
- NCT06242444
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- HALEON
Labor Pain
Alternative Method: Chewing Gum in Labor
This study is a clinical trial. It aimed to examine the effects of chewing gum on pain, anxiety, fatigue, and thirst in pregnant women (47 experiments; 47 controls) in the first stage of labor.
- Trial name
- NCT06959940
- Testing
- experimental group (gum group)
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Biruni University
Metabolic Syndrome
Nitrate Supplementation and Cerebrovascular and Cognitive Function in Metabolic Syndrome
The purpose of this study is to determine if beetroot juice consumption can improve cognitive performance and brain vascular function in individuals with metabolic syndrome
- Trial name
- NCT05532423
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Penn State University
Venous Thromboembolism (VTE), Intensive Care Medicine
Pulsed Electromagnetic Field Therapy or Pneumatic Compression VTE Prophylaxis
Venous thromboembolism (VTE) is frequent in patients in the intensive care unit (ICU). Pharmacologic prophylaxis is sometimes contraindicated, and mechanical prophylaxis is used.
- Conditions
- Venous Thromboembolism (VTE), Intensive Care Medicine, Venous Thromboembolism
- Trial name
- SOPHIE (NCT06958588)
- Testing
- Experimental: Hyperslim, Active Comparator #1
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Science Valley Research Institute
Toilet Training, Autism
Web-Based Animated Training:Mother-Child School
Introduction: Toilet training is the training that helps children gain control of their urine and stool while they are asleep and awake, and to recognize that they need to go to the toilet and relieve themselves without being…
- Conditions
- Toilet Training, Autism, Breast Feeding
- Trial name
- NCT06537271
- Testing
- experimental group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Igdir University
Metastatic Colorectal Cancer (mCRC), Colorectal Neoplasms
Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes
This study will evaluate efficacy and safety of hydroxychloroquine combined with methotrexate, capecitabine and bevacizumab versus regorafenib in participants with refractory metastatic colorectal cancer with mutations in KRAS or…
- Trial name
- x-МАР (NCT06949982)
- Testing
- experimental group x-MAP, Regorafenib (BAY 73-4506)
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Sergey Orlov, MD
Periodontal Indexes, Oral Health
The Effect of Disclosing Dental Plaque on Plaque Index and Gingival Index in Faculty of Dentistry Students
The hypothesis of this study is; using the tooth disclosing agents by individuals has a positive effect on oral care and as if it is an effective method in improving oral health.
- Trial name
- NCT06080672
- Testing
- Experimental: Group 1 (dental examination-training-tooth brushing) Experimental: Group 2 (dental examination-training-plaque disclosing-tooth brushing)
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
High-Risk Pregnancies
The Effect of Paint-by-Numbers Activity on Stress and Prenatal Attachment in High-Risk Pregnancies
Pregnancy, a physiological state, is defined both as a turning point and a developmental crisis . Pregnancy directly affects maternal and child health, and in cases of complications, it can lead to morbidity and mortality…
- Trial name
- NCT06955312
- Testing
- Experimental
- Volunteers
- 60 people
- Sponsor
- Erzurum Technical University
Cerebral Palsy
enGIneering For sporT for All
hemiplegia is a pathological condition that affects one side of the body which is associated with difficulty in maintaining an upright posture and walking and which is commonly compensated for by using orthoses (AFO).
- Trial name
- GIFT (NCT04794114)
- Testing
- experimental ankle foot orthosis, traditional ankle foot orthosis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea