Clinical trials: Experimental, completed
Asthma
Bioequivalence Study of Methacholine for Inhalation (pharmacodynamics)
This trial was divided into two parts. This is the scecond part. The second part is the pharmacodynamic equivalence study of patients, which is a single-dose, randomized, open, two-cycle, two-sequence crossover design, and plans…
- Trial name
- NCT06725641
- Testing
- Test preparation：Methylcholine chloroacetate for inhalation, Reference preparation：Methylcholine chloroacetate for inhalation（Provocholine）
- Where
- China
- Volunteers
- 40 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Subjects
Study Evaluating The Mass Balance And Metabolic Disposition Of SKI-606
This study will assess the mass balance, metabolic disposition, and identification of metabolites following single oral administration of [14C]-SKI-606 in healthy male subjects.
- Trial name
- NCT00757341
- Testing
- SKI-606
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Influenza A
Study of Efficacy and Safety of IV VIS410 Plus Oseltamivir Versus Oseltamivir in Hospitalized Adults With Influenza A
This study is to compare the efficacy and safety of VIS410 in combination with oseltamivir vs oseltamivir alone in severely ill subjects with influenza A infection requiring oxygen support.
- Trial name
- NCT03040141
- Testing
- Low dose of VIS410, High dose of VIS410
- Where
- 114 sites in United States, Australia and 18 more
- Volunteers
- 89 people
- Sponsor
- Visterra, Inc.
Socket Preservation
Clinical and Radiographic of the Effect of Socket Preservation Using the Roll Pedicle Connective Tissue Graft With Bovine Bone: A Case Series Trial.
After tooth extraction, the residual alveolar ridge generally provides limited bone volume because of ongoing, progressive bone resorption.
- Trial name
- NCT05255341
- Testing
- roll pedicle connective tissue graft with bovine bone
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nutrition Immunology
Cranberry Supplementation, Viral Defense, Antibody Response to the Flu Shot
This study will investigate the effect of 8-weeks cranberry supplementation on the antibody response to influenza vaccination and ex-vivo anti-viral activity.
- Trial name
- NCT04597554
- Testing
- Cranberry
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Individuals With Serious Mental Illness Leaving Jails
Peer Navigation for Individuals With Serious Mental Illness Leaving Jail
Serious mental illness (SMI) is a burdensome and widely prevalent public health problem among incarcerated men and women. Incarcerated individuals with SMI re-entering the community after jail stay experience the double stigma of…
- Trial name
- NCT04256954
- Testing
- Peer navigation intervention
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Michigan State University
Social Psychology
Vasopressin and the Social Brain
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, the investigators are still learning about the complex biological processes that contribute to positive…
- Trial name
- NCT02394054
- Testing
- Intranasal vasopressin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Upper Gastrointestinal Bleeding
Usefulness of Metoclopramide to Improve Endoscopic Visualization in Upper Gastrointestinal Bleeding
A prospective, randomized, double-blind study will be conducted, including all patients with upper gastrointestinal bleeding, defined as vomiting blood or black bowel movements, within 24 hours prior to admission.
- Trial name
- NCT06297954
- Testing
- Metoclopramide
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Venous Leg Ulcer, Pressure Ulcer
Confirm Safety and Performance of Avance Solo and Avance Solo Adapt NPWT Systems
The primary objective of this post market clinical follow-up (PMCF) investigation is to confirm the safety and performance of Avance®Solo and Avance®Solo Adapt NPWT Systems in low to moderate exuding chronic wounds when used in…
- Conditions
- Venous Leg Ulcer, Pressure Ulcer, Diabetic Foot Ulcer, Chronic Ulcer
- Trial name
- ASOLO-CW (NCT04753294)
- Testing
- Avance Solo NPWT System, Avance Solo Adapt NPWT System
- Where
- 13 sites in Belgium, Denmark and 5 more
- Volunteers
- 136 people
- Sponsor
- Molnlycke Health Care AB
Social Behavior
Oxytocin Effects on Self and Other Processing
To determine whether the neuropeptide oxytocin (OXT) influences self-processing by investigating whether it increases the endowment effect in relation to both self and others.
- Trial name
- NCT02963194
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Ulcer Foot, Chronic Skin Ulcer
Platelet Rich Plasma (PRP) Bio Stimulant Gel Dressing in Treating Chronic Non Healing Leg and Foot Ulcers: Cost and Effectiveness
Background Chronic non-healing ulcer is a common problem met in clinical practice and represents a burden to the patients. Chronic ulcer lacks growth factors (GFs) to promote the healing process and is frequently followed by…
- Conditions
- Ulcer Foot, Chronic Skin Ulcer, Non-Healing Ulcer of Skin
- Trial name
- NCT04065594
- Testing
- PRP dressing, conventional ordinary dressing
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Insomnia Due to Mental Disorder
CBT-I as Early Intervention of Mood Disorders
This study aims to investigate the effectiveness of transdiagnostic nurse-administered 4-session group cognitive behavioral therapy for insomnia (CBT-I) plus standard care, compared to standard care alone, for improving sleep and…
- Trial name
- NCT03000894
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Small Intestine
Healthy Fat, Happy Microbiome (TAPIR), Proof-of-Concept Study
Rationale: The role of dietary lipids in host-microbiome research has for a long time been overlooked; as high lipid intake has been recently indicated to have the most pronounced effect on the small intestinal microbiome…
- Trial name
- TAPIR (NCT06064266)
- Testing
- plant-based mild ketogenic controlled diet, high-fat shake
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Perinatal Depression
A Smartphone-Assisted Brief Behavioral Intervention for Pregnant Women With Depression
Investigators developed Motherly 1.0, a smartphone app designed to treat and promote maternal mental health. A 2-arm parallel-randomized controlled clinical trial (RCT) will be conducted to test the efficacy of Motherly in…
- Trial name
- NCT04495166
- Testing
- Motherly 1.0, Brief Psychotherapy, Educational app
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- University of Sao Paulo
Brain Edema, Brain Tumor
XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors
The purpose of this study is to compare the safety and efficacy of XERECEPT® to dexamethasone (Decadron) a common treatment for symptoms of brain swelling (edema).
- Trial name
- NCT00088166
- Testing
- hCRF
- Where
- 34 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Celtic Pharma Development Services
eHealth, Coronary Artery Disease
Effectiveness of eHealth on the Self-management of Health Status and QOL Among CAD Patients
This article uses the smart medical case management tracking system, combined with various terminal devices to fully record the measured data (pulse, blood pressure) for case home care tracking to prevent the occurrence and…
- Conditions
- eHealth, Coronary Artery Disease, Quality of Life, Self-management
- Trial name
- NCT04146766
- Testing
- eHealth
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Defense Medical Center, Taiwan
Bladder Cancer
Comparative Study of Hexvix Blue Light Cystoscopy and White Light Cystoscopy in the Detection of Bladder Cancer
A study to compare Hexvix Blue light cstoscopy with standard White light cystoscopy in the detection of bladder cancer.
- Trial name
- NCT05600322
- Testing
- Hexaminolevulinate Hydrochloride, Richard Wolf Photodynamic Diagnostic Equipment (PDD) system
- Where
- 7 sites in China
- Volunteers
- 158 people
- Sponsor
- Photocure
Breast Milk Collection, Overweight and Obesity
Acute Effects of Endurance Exercise on Breast Milk Composition in Women With Overweight/Obesity
The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on…
- Trial name
- YT (NCT05745922)
- Testing
- Moderate intensity exercise, High intensity exercise
- Where
- Norway
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Incisional Hernia
Does the Use of Prophylactic Mesh Reduce Incisional Hernia?
Incisional hernia is a common condition after abdominal surgery. Because linea alba has less vascularity, incisional hernia more common in midline incisions. It is seen in the general population between 11-20%.
- Trial name
- NCT04700956
- Testing
- primary abdominal closure, abdominal closure with prophylactic mesh
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Konya City Hospital
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