Clinical trials: Experimental, completed
Presbyopia
The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia
Presbyopia is a condition where the eyes cannot focus a clear image on the retina when looking at nearby objects, commonly seen in people over 40 years old, which has a serious impact on people's daily work and life.
- Trial name
- NCT07151612
- Testing
- Esculin and Digitalisglycosides Eye Drops, Normal saline solution
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Shanxi Eye Hospital
Prostate Cancer
A Study to Evaluate the Effect of Multiple Doses of Enzalutamide on the Pharmacokinetics of Substrates of P-glycoprotein (Digoxin) and Breast Cancer Resistant Protein (Rosuvastatin) in Male Subjects With Prostate Cancer
The primary purpose of this study is to determine the effect of multiple once daily administrations of enzalutamide on the pharmacokinetics of a single dose of digoxin (P-glycoprotein (P-gp) substrate) and rosuvastatin (breast…
- Trial name
- NCT04094519
- Testing
- enzalutamide, digoxin, rosuvastatin
- Where
- Moldova
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Influenza, Orthomyxoviridae Infections
A Study of the Immunogenicity and Safety of the 2006-2007 Influenza Vaccine
This study is designed to generate clinical data as outlined in the Note for Guidance on harmonization requirements for influenza vaccine marketing authorization by the European Medicines Agency.
- Trial name
- NCT00343681
- Testing
- Inactivated influenza vaccine (split virion)
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Hypertension, Blood Pressure
iPhone App Compared to Standard RR-measurement
In this Trial we compare a new application (App) running on an iPhone (Apple inc., Model 4S) to determine systolic blood pressure (RR) and compare it to conventional oscillometric measurements using an Omron HBP-1300-E Pro…
- Trial name
- iPARR (NCT02552030)
- Testing
- cuff device (Omron HBP-1300-E Pro), iPhone 4s
- Where
- Switzerland
- Volunteers
- 1,019 people, healthy volunteers welcome
- Sponsor
- Jens Eckstein
Glioblastoma
Phase 0 Analysis of Ixazomib (MLN9708) in Patients With Glioblastoma
This phase 0 trial studies ixazomib citrate in treating patients with glioblastoma that has spread or returned after period of improvement who are planning to undergo surgery.
- Trial name
- NCT02630030
- Testing
- Ixazomib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Chronic Disease, Lung Diseases, Obstructive
Holistic Wellbeing in COPD: Communication About Sexuality (COSY)
The aim of this study is to assess the effectiveness of a communication intervention about sexuality on quality of life and other outcomes like physical activity, exercise capacity and health status in people with chronic…
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- NCT05696730
- Testing
- Communication intervention about sexuality in people with COPD
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Pregnant Adolescents
Effects of Empowerment Program Integrated With Family Support on Maternal Self-esteem and Quality of Life Among Palestinian Pregnant Adolescents
Adolescent pregnancy leads to increase risks and complications for the adolescent mother and her newborn. This study aims to examine the effects of empowerment program integrated with family support on maternal self-esteem and…
- Trial name
- NCT05031130
- Testing
- Empowered program integrated with family support
- Where
- Palestinian Territories
- Volunteers
- 71 people
- Sponsor
- Prince of Songkla University
Labor Pain
A Novel Approach to Optimize Programmed Intermittent Epidural Bolus (PIEB) Delivery for Labour Analgesia
Programmed intermittent epidural bolus (PIEB) for labour analgesia allows an epidural pump to be programmed to deliver small amounts of the local anesthetic and opioid solution at regularly timed intervals.
- Trial name
- NCT03871530
- Testing
- Coordinate A, Coordinate B, Coordinate C
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- IWK Health Centre
Glioblastoma Multiforme
A Study of Avastin (Bevacizumab) and Irinotecan Versus Temozolomide Radiochemistry in Patients With Glioblastoma
This 2 arm study will compare the effect of Avastin + irinotecan versus temozolomide, in combination with conventional involved field radiotherapy, in patients with newly diagnosed glioblastoma and a non-methylated MGMT promoter.
- Trial name
- NCT00967330
- Testing
- bevacizumab [Avastin], irinotecan, temozolomide
- Where
- 24 sites in Germany
- Volunteers
- 182 people
- Sponsor
- Hoffmann-La Roche
Healthy Volunteers, Dyslipidaemia
A Study to Look at How Safe a New Medicine (NNC0491-6075) is in Healthy People and in Participants With High Levels of Fat in the Blood
The study is testing a new study medicine to treat people with high levels of fat in the blood. The main aim of the study is to see if the new study medicine is safe and how it works in the body.
- Trial name
- NCT05979428
- Testing
- NNC0491-6075
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Hypertension
A Phase 2 Exploratory Study of CS-3150 in Japanese Hypertensive Patients With Moderate Renal Impairment
This study is a multi-center, open label, dose titration, exploratory study to evaluate efficacy and safety of CS-3150 in Japanese hypertensive patients with moderate renal impairment.
- Trial name
- NCT02448628
- Testing
- CS-3150
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Daiichi Sankyo
Colorectal Cancer
Study to Assess Safety and Tolerability of G17DT in Patients With Colorectal Adenocarcinoma.
Pancreatic, gastric, and colorectal cancers have all been shown to overexpress the gastrin gene and to be sensitive to the trophic effects of the gastrin in animal models.
- Trial name
- CC1A&B (NCT02181465)
- Testing
- G17DT
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- Cancer Advances Inc.
Wilsons Disease
sCD163 and sMR in Wilsons Disease - Associations With Disease Severity and Fibrosis
The aim is to investigate macrophage activation markers and correlations to liver fibrosis in patients with Wilsons Disease. Researchers wish to investigate associations to neurologic and metabolic liver function.
- Trial name
- NCT02702765
- Testing
- Fibroscan, Ultrasound, Galactose
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- University of Aarhus
Obstructive Sleep Apnea Syndrome
Home Nasal Pressure for Sleep Apnea Management in Primary Case
Primary objectives: To determine the efficacy and cost-effectiveness of a management program for patients with obstructive sleep apnea syndrome (OSAS) carried out in primary or specialist healthcare.
- Trial name
- Primary (NCT02141165)
- Testing
- Diagnosis, autoCPAP, follow up.
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Sexual Dysfunction, Intimacy Problems
RCT of an Internet-based CBT Program for Sexuality and Intimacy Problems in Women Treated for Breast Cancer
The purpose of this study is to evaluate the efficacy and cost-effectiveness of an internet-based cognitive behavioural therapy program in alleviating problems with intimacy and sexuality in women treated for breast cancer.
- Conditions
- Sexual Dysfunction, Intimacy Problems, Breast Cancer Survivors
- Trial name
- KIS (NCT02091765)
- Testing
- Internet-based cognitive behavioral therapy.
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- The Netherlands Cancer Institute
Striae Gravidarum
Efficacy of Fractional Carbon Dioxide Laser Combined With Platelet-rich Plasma
This study determined the efficacy of ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma versus ablative fractional carbon dioxide laser with placebo in the treatment of striae gravidarum of…
- Trial name
- NCT04956367
- Testing
- Ablative fractional carbon dioxide laser combined with autologous platelet-rich plasma, CO2 laser with PRP
- Where
- Philippines
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jose R. Reyes Memorial Medical Center
Sleep, Mood
A Study to Assess the Effects of Dietary Supplement Drinks on Sleep, Stress and Mood
A home placement, randomized, double blind, placebo-controlled, study to determine the effect of dietary liquid shot beverage products on self-reported measures of sleep, stress and mood on generally healthy participants with…
- Conditions
- Sleep, Mood, Stress
- Trial name
- NCT06378567
- Testing
- Dietary supplement liquid shot beverage products
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- The Water Street Collective
Malignant Neoplasms of Urinary Tract, Bladder Cancer
Investigation of Sugammadex in Outpatient Urological Procedures
The goal of this clinical research study is to determine whether using sugammadex, given with a standard muscle relaxation drug during bladder surgeries, improves anesthesia conditions and recovery time.
- Trial name
- NCT03138967
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- M.D. Anderson Cancer Center
Non-Small-Cell Lung Carcinoma
Study of OSI-774 (Tarceva) in Previously Untreated Elderly Lung Cancer Patients
The primary purpose of this study is to determine whether the drug OSI-774 is less toxic and potentially as good as or better than standard chemotherapy drugs, when given to subjects with non-small cell lung cancer, who are 70…
- Trial name
- NCT00137800
- Testing
- OSI-774 (Tarceva)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Heart Diseases, Angina, Stable
RecoveryPlus Telerehab Platform Pilot Study
In this prospective, single-arm study, we will look at the initiation, participation, sustained engagement, and safety of 100 adult subjects (ages 45 years or older) with recent (within the past 60 days) clinician referral to CR…
- Conditions
- Heart Diseases, Angina, Stable, Angina Pectoris, Myocardial Ischemia
- Trial name
- NCT05804500
- Testing
- Cardiac Telerehabilitation (CTR) via the RecoveryPlus platform
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NODEHealth Foundation
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