Clinical trials: Experimental Group, open to volunteers
Vitiligo, Mesenchymal Stem Cells
Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Vitiligo
This study evaluates whether exosomes derived from human umbilical cord mesenchymal stem cells (hUMSCs-Exo) are safe and effective for treating vitiligo in adults.
- Conditions
- Vitiligo, Mesenchymal Stem Cells, Exosomes
- Trial name
- hUMSCs-Exo-VIT (NCT07519031)
- Testing
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Intravenous Infusion, Oral Prednisone, Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes (hUC-MSC-Exos) Local Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xijing Hospital
Alzheimer Disease (AD), Unwanted Loneliness
Intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer
The absence of social relationships negatively affects physical, psychological, and social health. In other words, it alters people's quality of life and makes active aging difficult.
- Conditions
- Alzheimer Disease (AD), Unwanted Loneliness, Family Caregivers, Living With Process
- Trial name
- NCT07639645
- Testing
- Multimodal intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Valencia
Periprosthetic Joint Infection (PJI)
A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 1/2, randomized, controlled, open-label, proof-of-concept study to evaluate the safety and tolerability, local and systemic PK profiles of TNP-2092 administered via IA injection on the basis of vancomycin IV and…
- Trial name
- NCT06889701
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- TenNor Therapeutics Inc.
Neoplasms (Cancer / Tumors), Geriatric Oncology
Optimising the Cancer Management of Older Patients by Early and Specific Geriatric Interventions.
The WARNING project proposes a new care organisation for older patients with cancer. The aim is to optimise management in daycare with early detection signs of geriatric syndromes and specific interventions.
- Trial name
- WARNING (NCT07704307)
- Testing
- WARNING Pack
- Volunteers
- 1,010 people
- Sponsor
- Poitiers University Hospital
Nonsuicidal Self-Injury
Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injury
The goal of this clinical trial is to learn if naltrexone works to treat nonsuicidal self-injurious behavior in adolescents and adults.
- Trial name
- NiNsSIB (NCT06622239)
- Testing
- Naltrexone
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Cerebral Palsy (CP), Functional Mobility
Effects of Task Oriented Circuit Training on Functional Mobility and Activity Participation in Cerebral Palsy
cerebral palsy hemiplegia often experiences motor problems that primarily affect one side of their body. Children with hemiplegia have difficulties in functional activities.
- Trial name
- NCT07275528
- Testing
- Experimental, CONVENTIONAL PHYSICAL THERAPY
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Foundation University Islamabad
Healthy
Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive…
- Trial name
- NCT07665216
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Pulmonary Disease, Chronic Obstructive
The Cohort Study for Chronic Obstructive Pulmonary Disease (COPD) in China
The purpose of this study is to establish the large COPD cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices and to monitor and improve clinical outcomes in this…
- Trial name
- NCT03044847
- Testing
- COPD group
- Where
- China
- Volunteers
- 3,800 people
- Sponsor
- Beijing Chao Yang Hospital
Aplastic Anaemia
A Multicenter, Randomized, Open-Label Study of Haplo-Cord HSCT for the Treatment of Aplastic Anemia
Aplastic anemia (AA) is a bone marrow failure disorder characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells.
- Trial name
- NCT07499284
- Testing
- Haploidentical hematopoietic cell transplantation combined with unrelated cord blood stem cells, Haploidentical hematopoietic cell transplantation
- Where
- 4 sites in China
- Volunteers
- 224 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Breast Neoplasms, Breast Carcinoma
Preoperative Radiation Therapy and Immediate Breast Reconstruction
The goal of this phase III randomized controlled trial (PRADAIIBE) is to assess if preoperative radiation therapy (Preop-RT) combined with immediate breast reconstruction (IBR) can safely improve both aesthetic and quality of…
- Conditions
- Breast Neoplasms, Breast Carcinoma, Breast Adenocarcinoma, Cancer
- Trial name
- PRADAIIBE (NCT06739655)
- Testing
- Preoperative radiotherapy, Postoperative radiotherapy, Immediate breast reconstruction
- Where
- 6 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Cancer Research Antwerp
Frailty, Thoracic
Auricular Acupressure in Prehabilitation
Complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits.
- Conditions
- Frailty, Thoracic, Prehabilitation, Lung Surgery
- Trial name
- NCT06516198
- Testing
- Auricular Acupressure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Left Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether closed-loop fNIRS-BCI neurofeedback(NF) targeting the left dorsolateral prefrontal cortex(DLPFC) can reduce cardiac autonomic arousal, indexed by baseline-corrected heart…
- Trial name
- HEART-SET-2 (NCT07244484)
- Testing
- Real-time fNIRS-based neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Healthy, Older Adults
Group-Based Exercise Intervention to Prevent Cognitive and Motor Decline
The goal of this clinical trial is to evaluate the efficacy of the Ideomotor Program in healthy older adults living in the community.
- Trial name
- NCT07494149
- Testing
- Ideomotor, Control
- Where
- 2 sites in Italy
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Bergamo
Small Cell Lung Cancer ( SCLC )
A Single-arm, Exploratory Clinical Study Evaluating the Efficacy and Safety of Bevacizumab in Combination With Anlotinib and Etoposide as First-line Therapy for Elderly Patients With Small-cell Lung Cancer or Those Who Are Intolerant to Intensive Chemotherapy
A single-arm exploratory clinical study to observe and evaluate the first-line treatment of elderly and treatment-intolerant patients with small cell lung cancer using benmelstobart in combination with anlotinib and etoposide.
- Trial name
- SCLC (NCT07728955)
- Testing
- benmelstobart in combination with anlotinib and etoposide
- Volunteers
- 64 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Developing a Consensus Framework to Standardize Isokinetic Testing Data Reporting
Standardizing Reporting Practices for Isokinetic Testing: a Delphi Study
Isokinetic testing plays a crucial role in research and clinical practice, particularly for evaluating muscle strength, functional performance, and imbalances between muscle groups in fields such as rehabilitation, sports…
- Trial name
- NCT06733116
- Testing
- Delphi method survey
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Podcast, Postpartum Woman
The Effect of Podcast Education on Postpartum Depression, Maternal Attachment, and Self-Care Agency in the Early Postpartum Period: A Randomized Controlled Trial
The population of the study, planned as a randomized controlled experimental design, consists of primiparous women who gave birth in the delivery unit of Istanbul Esenler Women's Health and Pediatric Diseases Hospital.
- Trial name
- NCT07460921
- Testing
- Providing discharge education via podcasts
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pregnancy, Anxiety
Mandala Coloring in Late Pregnancy
Anxiety, depression and poor sleep are common in the last months of pregnancy and often occur together. Medication options during pregnancy are limited, so simple, safe non-drug methods are needed.
- Conditions
- Pregnancy, Anxiety, Depression, Psychological Stress
- Trial name
- NCT07906743
- Testing
- Mandala Coloring Group
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Fidan Balkaya
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