Clinical trials: Experimental Group
Sexually Transmitted Diseases
Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of Age
The aim of this first time in human proof of concept (FTiH-PoC) study was to evaluate safety and reactogenicity, to demonstrate efficacy and to explore immunogenicity of GlaxoSmithKline's (GSK) Neisseria gonorrhoeae generalized…
- Trial name
- NCT05630859
- Testing
- NgG 12.5 µg investigational vaccine, NgG 25 µg investigational vaccine, NgG 50 µg investigational vaccine
- Where
- 23 sites in United States, Brazil and 6 more
- Volunteers
- 1,009 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Pain
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six…
- Trial name
- NCT05661903
- Testing
- Spinal Cord Stimulator Set to Minimal/No Stimulation Setting, Usual Care, Positron Emission Tomography / Magnetic Resonance Imaging
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital
Family Involvement/Empowerment, Family-centered Care
Effectiveness of Family-Integrated Newborn Care to Improve Outcomes for Preterm and Low-birth-weight Neonates
The goal of this quasi-experimental study is to learn if integrating family in newborn care units as a key partner can improve the outcomes of preterm and low-birth-weight neonates.
- Conditions
- Family Involvement/Empowerment, Family-centered Care, Intensive Care Units, Neonatal, Family Integrated Newborn Care
- Trial name
- FINC (NCT07364903)
- Testing
- Family Integrated Newborn Care, an intervention to integrate family in the care targeted their preterm and Low-birth weight neonates, Standard medical treatment
- Where
- 2 sites in Ethiopia
- Volunteers
- 1,020 people
- Sponsor
- Laerdal Foundation
Relapsed/Refractory Central Nervous System Lymphoma, Relapsed/Refractory Primary Central Nervous System Lymphoma
Autologous CD19-CD20-NKG2D-nsBicephali CAR-T for Relapsed/Refractory Central Nervous System Lymphoma
Central nervous system lymphoma (CNSL) includes primary CNS lymphoma (PCNSL) and secondary CNS lymphoma (SCNSL), with diffuse large B-cell lymphoma as the predominant pathological type.
- Conditions
- Relapsed/Refractory Central Nervous System Lymphoma, Relapsed/Refractory Primary Central Nervous System Lymphoma, Relapsed/Refractory Secondary Central Nervous System Lymphoma
- Trial name
- NCT07555561
- Testing
- Autologous CD19-CD20-NKG2D-nsBicephali CAR-T Cell Injection
- Where
- China
- Sponsor
- Beijing Boren Hospital
Rheumatoid Arthritis
Effects of Kinesiotaping for Hands Function in Rheumatoid Arthritis
The aim of this research is to compare the effects of I-shape and fan shape kinesiotape techniques on pain, range of motion, grip strength and ADLs of patients with Rheumatoid Arthritis.
- Trial name
- NCT05039242
- Testing
- Conventional Physical Therapy), Kinesiotaping with I shaped application, Kinesiotaping with Fan-shaped Application
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Low Back Pain
Effects of Mezieres Method on Muscle Imbalance, Body Awareness and Postural Alignment in Athletes With Lower Back Pain.
The current study is a randomized controlled trial aims to compare the effectiveness of the Mezieres Method combined with core stabilization versus routine physiotherapy involving core stabilization on muscle imbalance, body…
- Trial name
- MEZ-LBP (NCT07611669)
- Testing
- Mezieres method plus core stabilization, Routine physiotherapy (core stabilization)
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Green International University
Chronic Nonspecific Low Back Pain
Effects of SIS Therapy in Individuals With Chronic Nonspecific Low Back Pain
Brief Summary - buraya yapıştırın Chronic nonspecific low back pain is a common condition that can cause pain, limitations in daily activities, and reduced quality of life.
- Trial name
- NCT07839169
- Testing
- SIS Therapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Knee Arthroplasty
A Holistic Evaluation of the Effects of Healing Nursing Care Interventions on Frail Patient Undergoing Knee Arthroplasty and Their Caregivers
This study was designed to holistically examine the effects of curative nursing care practices based on human caring theory on frail patients and their caregivers undergoing knee arthroplasty.
- Trial name
- NCT07201454
- Testing
- nursing care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ataturk University
PEMF Effect
PEMF Stimulation on Physical Exercise in Sedentary People
The pulsed electromagnetic fields (PEMF) are a non-invasive therapy used for clinical treatments. Recent publications in exercise physiology showed that PEMF enhanced the velocity and the quantity of available muscle O2, and the…
- Trial name
- NCT06446466
- Testing
- PEMF ON-OFF, PEMF OFF-ON
- Where
- Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Non Small Cell Lung Cancer
Evaluate Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of AZD3759
This is a multi-center, open-label, dose escalation and phase I/II study, consisting of dose escalation in Part A and phase II study in Part B.
- Trial name
- NCT03360929
- Testing
- AZD3759
- Where
- 4 sites in China
- Volunteers
- 15 people
- Sponsor
- LYZZ Alpha Holding Ltd
Insulin Resistance, Obesity
Financial Incentives to Exercise for Adolescents
Among youth populations, American Indians have the highest prevalence of diabetes in the United States. This study will use exercise as the principal lifestyle modification approach to reduce the risk of diabetes in this…
- Conditions
- Insulin Resistance, Obesity, Sedentary Lifestyle
- Trial name
- MOVE (NCT01848353)
- Testing
- Exercise training
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Stroke, Ambulation Difficulty
Effect of Functional Electric Stimulation for Recovery of Dorsiflexion After Stroke
The purpose of this project is to investigate the effect of functional electrical stimulation (FES) for recovery of dorsiflexion after stroke.
- Conditions
- Stroke, Ambulation Difficulty, Hemiplegia
- Trial name
- NCT04945395
- Testing
- FES and Conventional training, AFO and Conventional training
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Danderyd Hospital
Healthy Adult Participants, Controlled Hypertension
Ginkgo Active App-Based Exercise Training
The purpose of this study is to investigate the effectiveness and usability of a Gingko app based exercise training in middle and older aged adults.
- Conditions
- Healthy Adult Participants, Controlled Hypertension, Controlled Diabetes
- Trial name
- NCT07411339
- Testing
- Ginkgo App-based Exercise Training, NIA Booklet Exercise
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Stroke
Effects of Whole Body Vibration in People With Chronic Stroke
The overall aim of the proposed study is to determine whether whole body vibration is beneficial in promoting bone health, physical fitness and neuromotor performance in patients with chronic stroke.
- Trial name
- NCT00937339
- Testing
- Whole body vibration therapy, Exercise on the vibration platform with the device turned off
- Where
- China
- Volunteers
- 82 people
- Sponsor
- The Hong Kong Polytechnic University
Corneal Deformity
Study to Evaluate the Product Performance of a New Silicone Hydrogel Contact Lens
This will be a randomized non-dispensing study comparing the overnight corneal swelling of an eye while wearing no contact lens to the Ultra contract lens.
- Trial name
- NCT02258139
- Testing
- B&L Investigational Contact Lens
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Arthritis, Juvenile Idiopathic
An Internet-based Self-management Program for Adolescents With Arthritis
The purpose of this study is to demonstrate the effectiveness of the "Taking Charge: Managing JIA Online" Internet intervention, when compared with an attention (static education only websites) control group in improving pain and…
- Trial name
- NCT01572896
- Testing
- Taking Charge: Managing JIA Online, Standard Medical Care and JIA Resource Center
- Where
- 11 sites in Canada
- Volunteers
- 333 people
- Sponsor
- The Hospital for Sick Children
Stroke, Sabacute Stroke
Bilateral Robot-assisted Upper Extremity Rehabilitation on Motor Recovery in People With Subacute Stroke
The goal of this clinical trial is to study the clinical effects of a robotic rehabilitation treatment through a bilateral exoskeleton (Bilateral Robot-Assisted Therapy-BRAT) during standard rehabilitation, on motor recovery…
- Trial name
- BILAX (NCT06906588)
- Testing
- Experimental, Control
- Where
- 3 sites in Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele Roma
COPD, Anxiety
Effect of Therapeutic Touch on Sleep Quality and Anxiety in Individuals With Chronic Obstructive Pulmonary Disease
Purpose: The purpose is to determine the effect of therapeutic touch on the sleep quality and anxiety of individuals with chronic obstructive pulmonary disease.
- Conditions
- COPD, Anxiety, Sleep
- Trial name
- NCT04842903
- Testing
- Therapeutic Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Abant Izzet Baysal University
Obesity & Overweight, Type 2 Diabetes
Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy
This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy.
- Conditions
- Obesity & Overweight, Type 2 Diabetes, Type 2 Diabetes (Adult Onset), Obesity Type 2 Diabetes Mellitus
- Trial name
- NCT07641361
- Testing
- Hydration Plus, Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Bacterial Infections, Bacterial Infections and Mycoses
Large Algorithm Setting and Validation Study
In this pilot study, prospectively acquired clinician-collected and participant-collected vaginal swab specimens will be obtained from up to 1000 individuals with signs and symptoms of vaginitis to develop and validate a…
- Conditions
- Bacterial Infections, Bacterial Infections and Mycoses, Infections, Vaginitis
- Trial name
- LAVA (NCT07607470)
- Testing
- Nanopath Vaginitis Assay, BD Max™ Vaginal Panel, Cepheid Xpert® Xpress MVP
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nanopath, Inc
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