Clinical trials: Hydrocortisone
Adrenal Insufficiency, Polymyalgia Rheumatica (PMR)
Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment
Cortisol, a glucocorticoid (GC) hormone secreted from the adrenal glands, is essential for survival. Cortisol also possesses anti-inflammatory actions and GC formulations (prednisolone) are used to treat many inflammatory…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica (PMR), Giant Cell Arteritis (GCA)
- Trial name
- REPLACE (NCT05193396)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Marianne Andersen
Cushing Syndrome, Metabolic Syndrome
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome.
- Trial name
- HEPACORT (NCT05911620)
- Testing
- Magnetic resonance elastography (MRE)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Central Hospital, Nancy, France
Breast Cancer
Effects of Hands-on-Healing vs. Touch for Fatigued Breast Cancer Survivors
This randomized controlled trial examines the efficacy of hands-on-healing for fatigue and immune function in breast cancer survivors.
- Trial name
- NCT00440089
- Testing
- Hands-on-Healing
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of California, San Diego
Children Receiving Prednisone or Prednisolone or Methylprednisolone or Hydrocortisone
Pharmacokinetics of Glucocorticoids in Children (GLUCOPED)
The purpose of this study is to determine individual susceptibility factors (drug interactions, genetic factors such as enzyme polymorphism…) to explain wide interindividual variability towards corticosteroids (prednisone…
- Trial name
- GLUCOPED (NCT02252237)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
NSCLC
A Prospective Observational Study of Changes in Cortisol Levels After Neoadjuvant Immunotherapy and Their Prognostic Value in Patients With NSCLC
This study is an open, prospective and observational clinical trial. Adopting a prospective cohort study design, it selects patients with non-small cell lung cancer who receive neoadjuvant immunotherapy as the research subjects.
- Trial name
- NCT07530276
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute Liver Failure
To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial, investigator aim to evaluate the impact of early initiation of CRRT on outcomes in patients with acute liver failure with cerebral edema and hyperammonemia in improving cerebral…
- Trial name
- NCT04991259
- Testing
- Continuous Renal Replacement Therapy (CRRT), Standard Medical Treatment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Diabetes Mellitus, Type 1, Adrenal Insufficiency
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal Failure
The purpose of this study is to measure how often low blood sugars occur in people who live with both adrenal insufficiency (AI) and diabetes and need to take insulin.
- Conditions
- Diabetes Mellitus, Type 1, Adrenal Insufficiency, Diabetes Mellitus Type 2 - Insulin-Treated
- Trial name
- HYPO-DIAD (NCT05806190)
- Testing
- Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Imperial College Healthcare NHS Trust
Stress, Psychological, Father-Child Relations
Hair Cortisol as Marker of Chronic Stress in Preterm and Term Fathers - Fathair-study
The goal of this observational study is to compare the paternal hair cortisol as a marker for chronic stress in prematurely born children to maturely born children.
- Conditions
- Stress, Psychological, Father-Child Relations, Premature Birth
- Trial name
- NCT05969431
- Testing
- measurement of cortisol level
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Symphysis Onlay Bone Graft, Platelet Rich Fibrin
Effect of Symphysis Onlay Bone Graft, Injectable Platelet Rich Fibrin (I-PRF) and Xenograft on Horizontal Alveolar Ridge Augmentation in Esthetic Zone
The aim of the study: was to evaluate whether mandibular symphysis Onlay autogenous bone graft mixed with Injectable PRF could offer any advantages for patients undergoing horizontal alveolar ridge widening regarding increase…
- Conditions
- Symphysis Onlay Bone Graft, Platelet Rich Fibrin, Xenograft, Horizontal Alveolar Ridge Augmentation
- Trial name
- NCT06388837
- Testing
- Injectable Platelet Rich Fibrin, Xenograft
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- October 6 University
Thyroid Disfunction, Subarachnoid Haemorrhage From Cerebral Aneurism Rupture
Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage
Recently, the occurrence and potential impact of pituitary dysfunction after aSAH has gained increasing interest. Several studies have demonstrated pituitary dysfunction after SAH suggesting that pituitary dysfunction may be a…
- Conditions
- Thyroid Disfunction, Subarachnoid Haemorrhage From Cerebral Aneurism Rupture, Pituitary Disfunction
- Trial name
- TIRASH (NCT02915380)
- Testing
- Evaluation of pituitary endocrine function, Evaluation of clinical outcome, Evaluation of neuropsychological function
- Volunteers
- 50 people
- Sponsor
- Dr. Rita Bertuetti
Stress, Trauma
Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness
The purpose of this study is to investigate justice-involved Black/African American female adolescents' (JI BAFAs; N=35) self-reported outcomes: stress, posttraumatic stress disorder (PTSD), recidivism, etc., as well as their…
- Conditions
- Stress, Trauma, PTSD, HPA
- Trial name
- NCT06311188
- Testing
- ITR Healing intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cataract Surgery, Stress Levels
The Effects of Music on Perioperative Outcomes in Cataract Surgery
The hypothesis of this trial is that listening to music will decrease the stress levels that patients face as evidenced by their STAI scores, salivary cortisol levels and intra-operative autonomic parameters.
- Conditions
- Cataract Surgery, Stress Levels, Music Improving Outcomes in Cataract Surgery
- Trial name
- NCT03873454
- Testing
- Sennheiser non-occlusive headphones, Sennheiser non-occlusive headphones without music, No Sennheiser non-occlusive headphones
- Where
- 2 sites in Singapore
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Stress, Psychological, Burnout, Professional
Online Mindfulness Program for Stress Management
This is a prospective parallel non-blinded randomized study with two arms, an intervention group and an active control group. Sixty healthy, but stressed nurses will be randomly assigned to either participate in a 6-week…
- Trial name
- IGEM (NCT03753360)
- Testing
- Internet-Based Mindfulness Program - Stress Free Now for Healers, Active Control Group - Relaxing Music
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The Cleveland Clinic
Infections
The Effects of Hydrocortisone in Endotoxemia in Normal Volunteers
Corticosteroids are substances produced by the adrenal gland to help the body fight against infection or injury. Hydrocortisone is a man-made form of this substance.
- Trial name
- NCT01064986
- Testing
- Endotoxin, Lipopolysaccharide, LPS, Endotoxin, Lipopolysaccharide, LPS /Epinephrine, Hydrocortisone
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Post-traumatic Stress Disorder
Trial of Hydrocortisone for Post-Traumatic Stress Disorder (PTSD)
Developing novel and effective pharmacologic interventions for this post-traumatic stress disorder is important. The investigators propose to replicate findings of an earlier published pilot study using low dose hydrocortisone as…
- Trial name
- NCT00706173
- Testing
- Hydrocortisone
- Where
- United States
- Sponsor
- University of California, San Diego
Postresuscitation Syndrome
HYdrocortisone and VAsopressin in Post-RESuscitation Syndrome
The primary objective is to demonstrate the superiority of arginine-vasopressin (AVP) and hydrocortisone compared with norepinephrine regarding day-30 survival and neurological recovery in post-cardiac arrest patients with…
- Trial name
- HYVAPRESS (NCT04591990)
- Testing
- Administration of AVP, Administration of hydrocortisone
- Where
- 14 sites in France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Health Behavior, Quality of Life
Yoga Effects on Heart Rate Variability and Electroencephalography
Since yoga breathing exercises are traditionally used to tranquilize the mind, and have a well-known positive effect on the cardiovascular system, it is our hypothesis that a respiratory yoga exercise named bhastrika pranayama…
- Trial name
- NCT01866683
- Testing
- 1 month respiratory training, 1 month waiting period
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Intubation Complication
Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels
The sample was randomly divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. These groups will be checked for hemodynamic changes and cortisol values.
- Trial name
- NCT06516861
- Testing
- Magnesium Sulfate 20 MG/ML, Lidocaine IV, saline solution
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arsil Radiansyah
Phimosis
Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children
Topical steroids are used as treatment for non-retractile foreskin in children for decades, but, there are disagreement among physicians about the optimum potency of the agent used.
- Trial name
- TopSteP (NCT00933023)
- Testing
- hydrocortisone, Betamethasone
- Where
- United Kingdom
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Primary Progressive Multiple Sclerosis
Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis
This study is a prospective Phase 1a open-label single- center trial. It will assess the safety of intrathecal administration of DUOC-01 cells to adults with Primary Progressive Multiple Sclerosis (PPMS).
- Trial name
- DUOC for MS (NCT04943289)
- Testing
- DUOC-01
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Joanne Kurtzberg, MD
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