Clinical trials: Hydrocortisone, completed
Blood Cancer, Leukemia
Allogeneic Transplantation From Related Haploidentical Donors
The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+ selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative regimen of total lymphoid irradiation (TLI)…
- Conditions
- Blood Cancer, Leukemia, Graft Versus Host Disease, Malignancy
- Trial name
- NCT00185692
- Testing
- non-myeloablative hematopoietic cell transplantation, Anti-Thymocyte Globulin, Cyclosporine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
Preoperative Anxiety, Cesarean Section
Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Cortisol Levels in Elective Cesarean Section
Preoperative anxiety is a common problem in patients undergoing elective cesarean section and may negatively affect perioperative outcomes through activation of the stress response, including increased cortisol levels.
- Conditions
- Preoperative Anxiety, Cesarean Section, Surgical Stress Response, Cortisol
- Trial name
- NCT07521592
- Testing
- Verbal Preoperative Information, Video-Based Preoperative Information
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Cardiogenic Shock
Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.
The purpose of this randomized controlled trial is to evaluate the hemodynamic effect of low dose corticosteroid therapy (hydrocortisone and fludrocortisone) in the treatment of adult cardiogenic shock.
- Trial name
- COCCA (NCT03773822)
- Testing
- Hydrocortisone + Flucortac
- Where
- 21 sites in France
- Volunteers
- 380 people
- Sponsor
- CMC Ambroise Paré
Asthma
Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects
This is a randomized, placebo-controlled, 2-period crossover, escalating repeat dose study, aiming to investigate whether higher potency of different inhaled corticosteroid confers an improvement in the topical efficacy to…
- Trial name
- NCT02991859
- Testing
- Fluticasone furoate (FF) Dry Powder Inhaler, Fluticasone propionate (FP) Dry Powder Inhaler, Budesonide (BUD) Turbuhaler
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 56 people
- Sponsor
- GlaxoSmithKline
Cushing's Syndrome
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Participants in study C-1073-400 (NCT00569582) will be invited to participate in this extension study to examine the long term safety of mifepristone in the treatment of the signs and symptoms of endogenous Cushing's syndrome.
- Trial name
- NCT00936741
- Testing
- mifepristone
- Where
- 15 sites in United States
- Volunteers
- 30 people
- Sponsor
- Corcept Therapeutics
Stress, Depression
The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)
The purpose of this study is to determine whether there is a change in levels of cortisol, a key stress hormone, during the course of a psychotherapy session.
- Conditions
- Stress, Depression, Anxiety
- Trial name
- NCT00641394
- Testing
- Psychotherapy: Emotional Freedom Techniques (EFT), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Septic Shock, Severe Sepsis
Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Severe sepsis/septic shock is a serious condition associated with high mortality rate. Hydrocortisone has been recommended as a useful treatment to decrease mortality in hemodynamically unstable septic shock patients, not…
- Conditions
- Septic Shock, Severe Sepsis, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT01284452
- Testing
- Hydrocortisone
- Where
- Thailand
- Volunteers
- 197 people
- Sponsor
- Mahidol University
Neurocognitive Function
Neurocognitive Function After Regional and General Anesthesia (245_14 B)
Postoperative cognitive dysfunction (POCD) is a disease with restricted cognitive memory function and intellectual skills, which occurs after surgery with and without anesthesia.
- Trial name
- 245_14_B (NCT02505815)
- Testing
- Surgery, Cortisol Level Measurement, Neurocognitive Testing
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Suprascapular Nerve Block, Axillary Nerve Block
The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block
Suprascapular nerve block (SSNB) is most commonly used for relieving postoperative pain of arthroscopic rotator cuff repair and it can be used in combination with axillary nerve block (ANB).
- Conditions
- Suprascapular Nerve Block, Axillary Nerve Block, Dexmedetomidine, Arthroscopic Rotator Cuff Repair
- Trial name
- NCT04398589
- Testing
- Dexmedetomidine injection, Saline injection
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Coagulation Dysfunction in Septic Shock, Hemodynamic Improvement Induced by Hydrocortisone
Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock.
- Trial name
- NCT02114710
- Testing
- Hydrocortisone
- Volunteers
- 240 people
- Sponsor
- Nanjing PLA General Hospital
Premature Birth of Newborn
Neuroendocrine Mechanisms of Developmental Massage Therapy (DMT) in Preterm Infants: Clinical Study
The purpose of this study is to see if daily massage therapy will help premature infants respond to stress better, as well as improve their growth and neurobehavioral development.
- Trial name
- DMT (NCT00722943)
- Testing
- Developmental Massage Therapy, no intervention
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Utah
Leukemia, Lymphoma
Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002471
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 4 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cigarette Smoking
Investigation of Nicotine Seeking Behavior in Current Smokers
In this study, 21 non-treatment-seeking cigarette smokers were recruited to investigate the effects of acute stress on brain function and nicotine seeking/self-administration behavior.
- Trial name
- NSS (NCT03670212)
- Testing
- Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wayne State University
Adrenal Insufficiency
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a physiologically high HC dose.
- Trial name
- SUPREME CORT (NCT01546922)
- Testing
- Hydrocortisone
- Where
- Netherlands
- Volunteers
- 63 people
- Sponsor
- University Medical Center Groningen
Preeclampsia, Anxiety
Psychosocial Effects of Coloring in Preeclamptic Pregnant Women
Preeclampsia is one of the major causes of maternal and neonatal mortality and morbidity, affecting approximately 3-5% of pregnancies.
- Conditions
- Preeclampsia, Anxiety, Pregnancy, Stress
- Trial name
- NCT06925841
- Testing
- Experimental, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Necmettin Erbakan University
Smokers
Effect of Behavioral Training on Physiological Responses to Smoking Cues, Affect and Cortisol
This study is ancillary. Participants will be recruited as part of a separate clinical trial on effects of two intensive behavioral training programs that evaluates feasibility and efficacy of a behavioral treatment that includes…
- Trial name
- physio (NCT01362101)
- Testing
- Mindfulness behavioral intervention (MT),cognitive behavioral intervention (CBT)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- A. Eden Evins
Early Interventions, Preterm Infants
Effects of Early Behavioral and Transaction Interventions on Preterm Infants' and Parents' Biopsychosocial Well-being
This randomized controlled trial will use a longitudinal repeated-measures design to examine the effects of two interventions, behavioral support interventions and a parent-infant transactional program, on parents' stress, PPD…
- Conditions
- Early Interventions, Preterm Infants, Parent-Child Relations
- Trial name
- NCT03013023
- Testing
- BS, Routine care, PITP
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Polycystic Ovary Syndrome
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycystic ovary syndrome of all body weights.
- Trial name
- NCT00694759
- Testing
- pioglitazone, metformin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Drug/Agent Toxicity by Tissue/Organ, Leukemia
05-001: Treatment of Acute Lymphoblastic Leukemia in Children
RATIONALE: L-asparaginase is an important component of treatment for childhood acute lymphoblastic leukemia, but is also associated with notable side-effects, including hypersensitivity, pancreatitis, and thrombosis.
- Trial name
- NCT00400946
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 8 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Psychotic Disorders
Hormonal and Inflammatory Biomarkers and Response to Cognitive Remediation in Recent-onset Psychosis
This study aims to explore whether hormones or inflammatory markers are associated with cognitive changes following cognitive remediation therapy (CRT) in people with a recent-onset psychotic disorder.
- Trial name
- NCT04418570
- Testing
- cognitive remediation, attendance to an Early Intervention Service for Psychosis
- Volunteers
- 28 people
- Sponsor
- Corporacion Parc Tauli