Clinical trials: Hydrocortisone, completed
Autonomous Cortisol Secretion (ACS), ACTH-Independent Cushing Syndrome
SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor
This is study with SPI-62 to evaluate the efficacy, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor. Each subject will receive 2mg of SPI-62 daily.
- Conditions
- Autonomous Cortisol Secretion (ACS), ACTH-Independent Cushing Syndrome, ACTH-Independent Adrenal Cushing Syndrome, Somatic
- Trial name
- ACSPIRE (NCT05436639)
- Testing
- SPI-62 dose
- Where
- 5 sites in United States, Romania and 1 more
- Volunteers
- 30 people
- Sponsor
- Sparrow Pharmaceuticals
Leukemia, Lymphoma
TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma
RATIONALE: Less intensive therapy may attain in the same results as intensive therapy in children with non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to study the effectiveness of less intensive therapy for children…
- Trial name
- NCT00002757
- Testing
- filgrastim, cyclophosphamide, cytarabine
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 1,148 people
- Sponsor
- Children's Oncology Group
Septic Shock
Thiamine, Vitamin C and Hydrocortisone in the Treatment of Septic Shock
The purpose of this research study is to determine whether patients who receive thiamine (vitamin B1), vitamin C and hydrocortisone while in septic shock have improved outcomes compared to hydrocortisone alone.
- Trial name
- NCT03540628
- Testing
- Thiamine and Vitamin C
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Corewell Health South
Rash
Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer
The purpose of this trial is to determine if rash caused by erlotinib can be successfully treated and if so to determine the optimal treatment approach.
- Trial name
- LUTRAERL (NCT00473083)
- Testing
- Minocycline, Clindamycin 2% in hydrocortisone 1% lotion, Erlotinib
- Where
- 9 sites in Canada
- Volunteers
- 150 people
- Sponsor
- British Columbia Cancer Agency
Atopic Dermatitis
Vitamin D in Egyptian Children With Atopic Dermatitis
There is an emergent evidence demonstrating the role of Vitamin D deficiency in eczema. Vitamin D supplementation with standard treatment yielded positive clinical outcomes for children and adolescents with mild and moderate AD…
- Trial name
- NCT04468711
- Testing
- Vitamin D
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Cushing Disease
Hair Cortisol and Cushing's Disease
The biochemical tools usable to assess the control of hypercortisolism in patients with Cushing's disease receiving medical treatments are debatable.
- Trial name
- HAIRCUSH (NCT04201444)
- Testing
- Patient group, Remission control group, Bilateral surrenalectomy control group
- Where
- 7 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
Food Insecurity
Cortisol and Food Insecurity
This study used a within-subjects design in a sample of individuals with a range of food insecurity recruited from the Los Angeles community (N = 400; 44.5% men).
- Trial name
- NCT05191030
- Testing
- High-Stress Intervention
- Where
- United States
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Infertility Unexplained, Fertility Disorders
Hypnofertility for Women Undergoing In Vitro Fertilization (HWUIVF)
This randomized controlled study aimed to specify whether the interventions based on Hypnofertility would lead to increased fertility preparedness and pregnancy outcomes, decreased cortisol levels of women undergoing In Vitro…
- Trial name
- NCT04141436
- Testing
- Interventions Based on Hypnofertility, Routine clinical procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Individuality
Effects of Mineralocorticoid Receptor Stimulation on Cognition
In this study the effects of mineralocorticoid stimulation on social cognition will be investigated in healthy young individuals.
- Trial name
- MR-STIM (NCT02478034)
- Testing
- Fludrocortisone
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Borderline Personality Disorder, PTSD
Neural Correlates of Stress Hormones
To investigate which neuronal correlates underlie cortisol-induced enhancement of memory retrieval in PTSD and BPD.
- Trial name
- Cort-fMRI (NCT02523664)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Endogenous Cushing's Syndrome
Cardiovascular Status in Patients With Endogenous Cortisol Excess (Cushing's Syndrome)
Within this trial, the cardiovascular and mental status as well as the metabolic profiles of patients with endogenous cortisol excess are evaluated.
- Trial name
- CV-CORT-EX (NCT03880513)
- Testing
- Cardiovascular status and quality of life
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Wuerzburg University Hospital
Cancer, Prostate Neoplasms
Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer
Prostate cancer (CaP) is the most commonly diagnosed cancer among males in the U.S. and the second leading cause of cancer-related mortality.
- Trial name
- TAPS (NCT00298155)
- Testing
- goserelin with dutasteride, goserelin with bicalutamide and dutasteride, goserelin with bicalutamide and dutasteride and ketoconazole
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Anxiety
Disentangling Anxiety Sensitivity and Anxiety-induced Physiological Stress Response
The proposed study aims to investigate experimentally anxiety sensitivity and physiologic sensations associated with anxiety using a paradigm combining hydrocortisone, caffeine, and a set of social stress challenges.
- Trial name
- NCT02372110
- Testing
- HPA, ANS stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Dental Anxiety, Dental Fear
Examining Stress Salivary Biomarkers in Pediatric Patients Undergoing Dental Procedures
Pediatric patients are susceptible to show signs of fear. One of the scenarios that have always been a source of fear is undergoing a dental procedure.
- Conditions
- Dental Anxiety, Dental Fear, Stress, Pediatric Population
- Trial name
- NCT06730425
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Leukemia
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Trial name
- NCT00096135
- Testing
- filgrastim, cyclophosphamide, cytarabine
- Where
- 153 sites in United States, Australia and 3 more
- Volunteers
- 168 people
- Sponsor
- Children's Oncology Group
Sleep Apnea, Sleep Disordered Breathing
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea
Patients with Obstructive Sleep Apnea Syndrome (OSAS) will evidence higher levels of salivary cortisol and alpha-amylase levels prior to use of placebo and continuous positive airway pressure (CPAP) and will evidence a decrease…
- Trial name
- NCT01196117
- Testing
- 14 days of CPAP therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical College of Wisconsin
Primary Aldosteronism
Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism
This study is to evaluate the performance characteristics of the seated saline infusion test and the ultra low-dose ACTH stimulation test for the diagnosis of primary aldosteronism.
- Trial name
- NCT04422756
- Testing
- Seated intravenous saline infusion test, Ultra low-dose ACTH stimulation test
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Oral Lichen Planus, Tumor Necrosis Factor-alpha
Efficacy of Aloe Vera Compared to Corticosteroid in Topical Treatment of Oral Lichen Planus and on Salivary Levels of Tumor Necrosis Factor Alpha
Aloe Vera Herbal treatment has been widely used as an anti-inflammatory and antioxidant the objective of this study was to evaluate the clinical efficacy of Aloevera gel compared to corticosteroid gel o for symptomatic oral…
- Trial name
- NCT07792512
- Testing
- aloevera gel, Topical Corticosteroid Creams (Triamcinolone acetonide 0.1% and Hydrocortisone 2.5%)
- Where
- 5 sites in Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteers
Safety, Tolerability, and Efficacy of Sublingual Microdoses of 5-MeO-DMT for Depression and Anxiety
This Phase I/II clinical trial investigates the safety, tolerability, and potential therapeutic benefits of a novel sublingual formulation of 5-MeO-DMT.
- Trial name
- 5-MeO-DMT (NCT06816667)
- Testing
- BMND08, Brain electrical activity monitor, Pharmacokinetic Study of Sublingually Administered Psychoactive Substance
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Biomind Labs Inc.
Stress Reaction
Validity for Stress Reduction of Virtual Reality Intervention
The purpose of this study is to verify the effect of virtual reality (VR) intervention on stress reduction for workers. After inducing stress by the Socially Evaluated Cold Pressure Test (SECPT), Investigators should explore…
- Trial name
- NCT07415239
- Testing
- virtual reality intervention, control intervention
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital