Clinical trials: Hydrocortisone
Adrenal Insufficiency
Hydrocortisone Vs Prednisolone in AI (HYPER-AID)
This study is designed to collect data on individuals with adrenal insufficiency who are changing treatments from hydrocortisone to prednisolone, or vice versa.
- Trial name
- HYPER-AID (NCT03608943)
- Testing
- There is no specific intervention other than an individual changing their treatment as part of their usual care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Laparoscopic Gynecological Surgery
Analgesic Effect of Pulmonary Recruitment and Intraperitoneal Hydrocortisone in Laparoscopic Gynecological Surgery
The aim of this study is to compare the postoperative analgesic efficacy of intraperitoneal hydrocortisone to pulmonary recruitment maneuver in Laparoscopic gynaecological surgery.
- Trial name
- NCT03845608
- Testing
- Pulmonary Recruitment Maneuver
- Volunteers
- 45 people
- Sponsor
- Cairo University
Acute Lymphoblastic Leukemia
Treatment of Acute Lymphoblastic Leukemia in Children
The purpose of this study is to reduce the side-effects from anti-leukemia therapy. The therapy in this study is based upon treatment information learned from prior clinical research programs as well as from laboratory research.
- Trial name
- NCT00165178
- Testing
- prednisone, dexamethasone, doxorubicin
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating Patients With Prostate Cancer
This phase I/II trial studies the side effects and best dose of calcitriol when given in combination with ketoconazole and therapeutic hydrocortisone and to see how well it works in treating patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, Recurrent Prostate Carcinoma, Stage III Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT00536991
- Testing
- Calcitriol, Ketoconazole, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Roswell Park Cancer Institute
Hematologic Malignancy, AML
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN).
- Conditions
- Hematologic Malignancy, AML, ALL, BPDCN
- Trial name
- NCT05476770
- Testing
- Tagraxofusp, Fludarabine, Cytarabine
- Where
- 31 sites in United States, Australia
- Volunteers
- 54 people
- Sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
Pregnancy
Effect of Maintenance of Intraoperative Normothermia in Cesarean Section on Thermal Comfort, Serum Cortisol and Apgar Score: A Randomized Controlled Trial
Cesarean section is a common method of delivery worldwide today. According to WHO, cesarean section accounts for more than 1 in 5 (21%) of all births, and it is predicted that approximately one-third (29%) of births will be by…
- Trial name
- NCT06962241
- Testing
- Warming group
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Spinal Anesthesia, Knee Arthroplasty
Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels
The aim of this study is to examine the effects of binaural beat music played during spinal anesthesia knee arthroplasty on anxiety, pain and cortisol levels.
- Trial name
- NCT06729294
- Testing
- Binaural beat music recital
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Nuh Naci Yazgan University
Exercise
Effects of HIIT and MICT Training on Cardiorespiratory Fitness, Testosterone/Cortisol Ratio, and Mental Health in Young Adults
This study will use a randomized, double-blind clinical trial to evaluate the effects of eight-week HIIT and MICT exercise programs on cardiorespiratory fitness, the testosterone/cortisol ratio, and mental health in 68 healthy…
- Trial name
- NCT07397702
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Postoperative Pain, Nursing Caries
Effect of Progressive Relaxation Exercise on Physiological Parameters, Pain, Anxiety in Colorectal Cancer Surgery
This research was carried out as an pre-test/post-test control group experimental design study in order to determine the effect of progressive relaxation exercises on the level of vital sign, pain and anxiety underwent who…
- Conditions
- Postoperative Pain, Nursing Caries, Anxiety
- Trial name
- NCT04731428
- Testing
- Progressive Relaxation Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- YASEMİN ÖZHANLI
Dry Eye, Meibomian Gland Dysfunction
Efficacy and Safety of Topical Hydrocortisone on Signs and Symptoms of Dry Eye Associated to Meibomian Gland Dysfunction
The purpose of this study is assess the efficacy and safety of topical hydrocortisone (Softacort) for treatment of clinical signs and symptoms of dry eye disease when associated with moderate meibomian gland dysfunction.
- Trial name
- NCT05159284
- Testing
- Hydrocortisone Ophthalmic, MGD Rx EyeBag® eyelid warming device, Lephanet® lid wipes
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Laboratorios Thea, Spain
Stress, Eating Behavior
Stress Reactivity Study in Adolescents
The goal of this study was to examine the glucocorticoid and behavioral responses to a psychological stressor in obese African-American and non-Latino white adolescents.
- Trial name
- SRAS (NCT03997149)
- Testing
- Acute Laboratory Stressor, Low affect video
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
The Effects of Oral Glucose Compared to Sweetener Drinking on Hormonal/Metabolic Responses
The goal of this study is to determine the hormonal/metabolic reponse to ingestion of sugar compared to consuming artificial sweetened drink, and to evalute macronutrient consumption 24 hours post ingestion of the drinks.
- Trial name
- NCT01683929
- Testing
- glucose, sweetner
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Alcohol Drinking, Alcohol Abuse
Novel Real-world Methods in Social Drinkers and AUD
This research project proposes a novel approach to elucidate the biological adaptations associated with Alcohol Use Disorder and to assess whether such adaptations are predictive of higher alcohol craving in response to both…
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- ALR (NCT05155176)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Yale University
Postpartum Depression, Insomnia
Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health
Improving maternal mental health is a worldwide health priority. Nevertheless, several scientific sources highlighted lack of empirical data which could drive clinical practice.
- Conditions
- Postpartum Depression, Insomnia, Stress
- Trial name
- MOTHERS (NCT06379074)
- Testing
- Improving sleep health and resilience during pregnancy, Information on pregnancy-related issues
- Where
- 2 sites in Italy
- Volunteers
- 114 people
- Sponsor
- University of Rome G. Marconi
Hypertension
Fludrocortisone's Test in Salt Sensitivity
The main hypothesis of this study is look for a clinical and fast test to identify salt sensitivity by administration of fludrocortisone.
- Trial name
- NCT01453959
- Testing
- Fludrocortisone, Diet cycles
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Fundação de Amparo à Pesquisa do Estado de São Paulo
Dermatitis, Atopic, Pruritus
The Efficacy of 3% Kanuka Oil Versus 1% Hydrocortisone Cream in Patients With Atopic Dermatitis
Atopic dermatitis is a common disease affecting millions worldwide. A common associated symptom in this population is pruritus. We seek to investigate the use of an natural, over-the-counter cosmeceutical to help this population
- Trial name
- NCT06488742
- Testing
- 3% kanuka oil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nexgen Dermatologics, Inc.
Inhospital Cardiac Arrest
Physiologic Effects of Steroids in Cardiac Arrest
Early stress-dose steroids are of uncertain efficacy in cardiac arrest. The current authors plan to conduct a prospective, randomized, placebo controlled evaluation of stress-dose steroids efficacy with repect to early…
- Trial name
- CORTICA (NCT02790788)
- Testing
- Methylprednisolone; hydrocortisone
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Systemic Inflammatory Response Syndrome, Hyperglycemia
The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome.
- Trial name
- AM (NCT00459511)
- Testing
- Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Stress
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy…
- Trial name
- NCT01673087
- Testing
- Metyrapone, Dexamethasone, Cortrosyn
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Metastatic Colorectal Cancer, Skin Rash
Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy
A comparison of prophylactic treatment with reactive treatment for skin toxicity observed in patients with metastatic colorectal cancer (mCRC) who are receiving second-line irinotecan-based chemotherapy concomitantly with…
- Conditions
- Metastatic Colorectal Cancer, Skin Rash, Skin Toxicities, Colon Cancer
- Trial name
- STEPP (NCT00332163)
- Testing
- Panitumumab, Irinotecan, FOLFIRI
- Volunteers
- 95 people
- Sponsor
- Amgen
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