Clinical trials: Hydrocortisone
Adrenal Insufficiency, Congenital Adrenal Hyperplasia
A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort Formulations
This was an open label, randomised, single dose study, comprising Part A (undertaken in two separate three-period crossover cohorts denoted as A1 and A2) and Part B (undertaken in one four-period crossover cohort), to evaluate…
- Trial name
- NCT03051893
- Testing
- Chronocort
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Stress, Noise Exposure
The Effect of Nonstress Test Device Noise Level on Stress Parameters in Primiparous Pregnant Women
Introduction: Prenatal tests can increase the stress levels of pregnant women. One of the tests performed to evaluate fetal health during pregnancy is the Nonstress Test (NST).
- Conditions
- Stress, Noise Exposure, Prenatal Stress, Prenatal Care Late
- Trial name
- NCT05488704
- Testing
- Stress Parameters Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Halic University
Ocular Inflammation, Ocular Prostheses
Comparison of Topical Treatment for Inflammatory Secretions of the Conjonctiva (Patients With Ocular Prostheses)
We propose to evaluate the efficacy of treatment with Hydrocortisone and Dexamethasone (in a cross-over design) in patients with ocular prostheses and significant functional discomfort.
- Trial name
- CRYSTAL (NCT05668455)
- Testing
- Hydrocortisone, Dexamethasone, Povidone
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Agnes
Irritable Bowel Syndrome
Effects of Aerobic Exercise and Pain Neuroscience Education in Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic disorder of gut-brain interaction characterized by abdominal pain and changes in bowel habits.
- Trial name
- NCT07397533
- Testing
- Exercise, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istinye University
Stress, Psychological
Correlation Between Blood Pressure, Heart Rate and Plasma Corticotropin, Cortisol Under Surgical Skin Incision
A prospective observational study was conducted to analyze the correlation between systolic blood pressure, diastolic blood pressure, mean arterial pressure，heart rate and plasma corticotropin, cortisol during surgical skin…
- Trial name
- NCT03892538
- Where
- China
- Volunteers
- 134 people
- Sponsor
- JingCang
Developmental Disability, Chronic Disease
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder…
- Conditions
- Developmental Disability, Chronic Disease, Down Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03602378
- Testing
- salivary cortisol, Holter Medilog AR12 Plus, Polar V800
- Where
- 2 sites in Croatia
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Borderline Personality Disorder, Oxytocin
Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder
This study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.
- Trial name
- OXT-CORT-BPD (NCT05357521)
- Testing
- stress test
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Infant, Newborn, Infant, Low Birth Weight
Early Blood Pressure Management in Extremely Premature Infants
This trial tests the feasibility of enrolling 60 extremely preterm infants in a randomized, double-blinded study of blood pressure management within 12 months.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- ELGAN BP (NCT00874393)
- Testing
- Dopamine, Hydrocortisone
- Where
- 17 sites in United States
- Volunteers
- 10 people
- Sponsor
- NICHD Neonatal Research Network
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Leukemia
Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy in treating children who…
- Trial name
- NCT00002816
- Testing
- cytarabine, dexamethasone, etoposide
- Where
- 33 sites in United States, Australia and 1 more
- Volunteers
- 120 people
- Sponsor
- Children's Oncology Group
Stress, Psychological, Stress, Emotional
Biology, Identity & Opportunity Study
This study will implement an intervention designed to promote ethnic and racial identity development. It is hypothesized that the intervention will have positive effects on ethnic-racial identity development, stress biology…
- Conditions
- Stress, Psychological, Stress, Emotional, Stress, Physiological
- Trial name
- BIO (NCT03412162)
- Testing
- Ethnic and Racial Identity Promotion, Academic Skills Promotion
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Asthma
Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma
Our study is a prospective double-blind randomized study performed in the Emergency Department (ED). The objective of our study was to demonstrate the additive effect of high and repeated doses of inhaled budesonide combined with…
- Trial name
- NCT04016220
- Testing
- Budesonide, normal saline
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University of Monastir
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anorexia Nervosa, Hypothalamic Amenorrhea
Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea
The purpose of this study is to determine whether the hormone dynamics in women with anorexia nervosa and hypothalamic amenorrhea is related to bone loss in those populations.
- Conditions
- Anorexia Nervosa, Hypothalamic Amenorrhea, Obesity
- Trial name
- NCT00556036
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Insulin Resistance
Hormonal Mechanisms of Sleep Restriction
The purpose of this study is to study the effects of sleep restriction on the production of two hormones, cortisol and testosterone.
- Trial name
- NCT02256865
- Testing
- Ketoconazole, Hydrocortisone, Testosterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sepsis
The Effect of Moderate-Dose Steroid Therapy in Sepsis
Despite the new developments in sepsis treatment, mortality rate is still high. Discussions on steroid treatment in sepsis are going on.
- Trial name
- NCT01275638
- Testing
- Prednisolone
- Volunteers
- 55 people
- Sponsor
- TC Erciyes University
Motivation
Motivational Interviewing Inadequate Milk and Cortisol
Motivational interviewing is a technique used in many fields. No study has been found in national and international databases investigating the effect of motivational interviewing on the perception of insufficient milk…
- Trial name
- NCT06344663
- Testing
- motivational interview
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Papilla Reconstruction
Modified Pedicle Subepithelial Connective Tissue Graft for Interdental Papillary Reconstruction Around Delayed Implants in the Esthetic Zone: A Case Series Trail
This case series trial aims to evaluate the effect of a modified pedicle subepithelial connective tissue graft in creating anatomical papilla around one-stage delayed implant in the esthetic zone to establish better esthetics.
- Trial name
- delay implant (NCT04843826)
- Testing
- papilla reconstruction
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ahmed Sadek Mohamed
Anxiety and Fear, Anesthesia
Evaluating Stress Response and Anxiety Score in Paediatric Patients
To date, there have been no studies done relating serum cortisol levels and intranasal dexmedetomidine sedation. However, there was a behavioral study done on pediatric patients confirming reduction serum cortisol levels with…
- Trial name
- NCT04526652
- Testing
- Dexmedetomidine
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
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