Clinical trials: Hydrocortisone
Hypertension, Mild Cognitive Impairment
Brain Connections and Blood Pressure
This pilot randomized controlled study evaluates Mindfulness and DASH Diet resting state network and blood pressure in 36 (n=12 intervention; n=12 attention control; n = 12 control) Black and African American older adults with…
- Trial name
- NCT03736434
- Testing
- Mindfulness and DASH Diet Education, Education group
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University
Pharmacodynamic
Evaluation of Vamorolone Mineralocorticoid Receptor Antagonism in Healthy Subjects
To evaluate if the trial drug vamorolone is able to block a specific receptor in the body called mineralocorticoid receptor. This receptor helps to regulate salt and water balance.
- Trial name
- NCT06649409
- Testing
- Vamorolone, Eplerenone, Fludrocortisone
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Santhera Pharmaceuticals
Implant Therapy, Class II Extraction Sockets
Customized CAD/CAM Titanium-Milled Abutments Vs. Custom Abutments Over Immediate Implants in Class II Extraction Sockets in the Esthetic Zone: a Randomized Controlled Clinical Trial
Background: Immediate implant placement in esthetic zones, particularly Class II and III extraction sockets, presents challenges related to soft and hard tissue changes post-extraction.
- Trial name
- NCT06791655
- Testing
- Stock Abutment Implant, Customized CAD CAM Titanium Milled Abutment Implant
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ain Shams University
Covid19, Critical Illness
Sex Hormone Dysregulations Are Associated With Critical Illness in COVID-19 Patients
Males develop more severe SARS-CoV-2 infection related disease outcome than females. Herein, sex hormones were repeatedly proposed to play an important role in Covid-19 pathophysiology and immunity.
- Trial name
- HAM-SEX-C19 (NCT04979091)
- Testing
- Sex Hormones
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Primary Aldosteronism Due to Aldosterone Producing Adenoma
Rapid Cortisol Assay in Adrenal Vein Sampling
Background: Adrenal vein sampling (AVS) is the gold standard test for the subtyping of primary aldosteronism (PA). This procedure is hampered by unsuccessful bilateral cannulation of adrenal veins, which can occur in up to two…
- Trial name
- I-PADUA (NCT03449797)
- Testing
- AVS performed with no intraprocedural rapid cortisol assay, AVS performed plus intraprocedural rapid cortisol assay
- Volunteers
- 200 people
- Sponsor
- University Hospital Padova
Neck Pain
Laser Therapy on Neck Pain in Adolescents
The aim of the proposed study is to investigate the effects of low-level laser therapy on neck pain.
- Trial name
- Cervicalgia (NCT01849913)
- Testing
- Laser
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Nove de Julho
TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY
Effect of Intrarectal Ice Application on Pain, Anxiety, Cortisol Levels, Development of Complications, and Hospital Readmission in Transrectal Ultrasound-Guided Prostate Biopsy
The aim of this study is to determine the effect of intrarectal ice application on pain, anxiety, cortisol levels, development of complications (rectal bleeding, hematuria, urinary retention, anemia, infection, etc.), and…
- Trial name
- NCT07462390
- Testing
- Intrarectal ıce
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tarsus University
Breast Cancer
A Trial Assessing Feasibility of Allostatic Load Biomarkers and CVD Risk Among Black Breast Cancer Survivors
This study's overall objective is to test the effects of a culturally tailored gratitude, exercise, and mindfulness/emotional freedom techniques (GEM) psychosocial intervention on allostatic load and atherosclerotic…
- Trial name
- GEM (NCT06852560)
- Testing
- Gratitude, exercise, and mindfulness program
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Acute Pancreatitis
Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis
Acute pancreatitis (AP) is a potentially life-threatening disease with varying severity of presentation. Nearly 60%-80% of all cases of AP in developed countries are attributable to either gallstone disease or alcohol abuse.
- Trial name
- NCT03830060
- Testing
- Measurement of cortisol
- Volunteers
- 50 people
- Sponsor
- Assiut University
Septic Shock
Initiation of Hydrocortisone for the Treatment of Septic Shock
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
- Trial name
- NCT02580240
- Testing
- Hydrocortisone, saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Northern Jiangsu People's Hospital
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating Patients With Prostate Cancer
This phase I/II trial studies the side effects and best dose of calcitriol when given in combination with ketoconazole and therapeutic hydrocortisone and to see how well it works in treating patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, Recurrent Prostate Carcinoma, Stage III Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT00536991
- Testing
- Calcitriol, Ketoconazole, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Roswell Park Cancer Institute
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Leukemia
Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and giving them in different ways may kill more cancer cells.
- Trial name
- NCT00002744
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 34 sites in United States, Australia and 1 more
- Volunteers
- 1,970 people
- Sponsor
- Children's Oncology Group
Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
The purpose of this study is to assess the efficacy and safety of opevesostat plus daily corticosteroids compared to alternative abiraterone acetate or enzalutamide in participants with Metastatic Castration-resistant Prostate…
- Trial name
- NCT06136650
- Testing
- Opevesostat, Dexamethasone, Fludrocortisone acetate
- Where
- 330 sites in United States, Australia and 37 more
- Volunteers
- 1,314 people
- Sponsor
- Merck Sharp & Dohme LLC
Congenital Adrenal Hyperplasia
Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal Hyperplasia
This study is a parallel arm, randomised, open-label study, including dose titration and admissions for four overnight stays for 24-hour endocrine profiles.
- Trial name
- NCT02716818
- Testing
- Chronocort®, standard glucocorticoid therapy
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Neurocrine UK Limited
Psychological Stress
Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST
With the aim of evaluating the putative impacts of emotion related personality factors on physical and mental disease and the mechanisms of these impacts, 58 students were submitted to a social stress test (Trier Social Stress…
- Trial name
- cortpersonal (NCT00451126)
- Where
- Belgium
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Leukemia, Lymphoma
Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with radiation therapy may kill more tumor cells.
- Trial name
- NCT00002700
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 44 sites in Belgium, Croatia and 8 more
- Volunteers
- 392 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Adrenal Hyperplasia, Congenital
Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
The conventional glucocorticoid replacement therapy in congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- CAH (NCT01771328)
- Testing
- Hydrocortisone, Cortisone acetate
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Haukeland University Hospital
Immunosuppression, Healthy
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
Background: Corticosteroids have been used to treat inflammation and immune system diseases for decades. However, despite their widespread use, there is little information on the specifics of how corticosteroids affect the immune…
- Conditions
- Immunosuppression, Healthy, Healthy Subjects
- Trial name
- NCT01281995
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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