Clinical trials: Hydroxychloroquine
Discoid Lupus Erythematosus
A Multicentre, Randomised, Double-blind, Positive-control Clinical Trial Evaluating Dihydroartemisinin Tablets for the Treatment of Discoid Lupus Erythematosus
This study is a multicentre, randomised, double-blind, double-dummy, phase II clinical trial with a positive-control group, designed to evaluate the efficacy and safety of dihydroartemisinin tablets in the treatment of discoid…
- Trial name
- NCT07557927
- Testing
- Dihydroartemisinin tablets, Hydroxychloroquine tablets
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Kunming Pharmaceuticals, Inc.
ANCA Associated Vasculitis, Microscopic Polyangiitis
Hydroxychloroquine in ANCA Vasculitis Evaluation
The purpose of this study is to find out whether hydroxychloroquine, in addition to background treatments, reduces disease activity in patients with Anti-Neutrophilic Cytoplasmic Autoantibodies (ANCA) Vasculitis, a group of…
- Conditions
- ANCA Associated Vasculitis, Microscopic Polyangiitis, Churg-Strauss Syndrome, Wegener Granulomatosis
- Trial name
- HAVEN (NCT04316494)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pneumonia
Randomised Evaluation of COVID-19 Therapy
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia. The treatments being investigated are: COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin…
- Trial name
- RECOVERY (NCT04381936)
- Testing
- Lopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
- Where
- 16 sites in Belgium, Estonia and 14 more
- Volunteers
- 70,000 people
- Sponsor
- University of Oxford
Adenocarcinoma of the Pancreas
Neoadjuvant mFOLFIRINOX With Perioperative Oral Hydroxychloroquine in Resectable Pancreatic Adenocarcinoma
This will be a phase I/II trial examining the safety and tolerability of pre-operative mFOLFIRINOX in combination with peri-operative oral hydroxychloroquine (FHQ) in the treatment of subjects with adenocarcinoma of the pancreas.
- Trial name
- NCT04911816
- Testing
- Hydroxychloroquine sulfate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- West Virginia University
Hepatocellular Carcinoma
Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma
Trans-arterial chemoembolization (TACE) is the most commonly used therapy for patients with unresectable hepatocellular carcinoma (HCC).
- Trial name
- TAQE (NCT05842174)
- Testing
- Hydroxychloroquine, Lipiodol
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Antiphospholipid Syndrome (APS)
Study of the Efficiency of Hydroxychloroquine on the Endothelial Dysfunction and Its Vascular Consequences During the Antiphospholipid Syndrome
This study evaluates the benefits of hydroxychloroquine on arterial function in antiphospholipid syndrome. Briefly, the patients will be randomized in two groups, one will receive hydroxychloroquine and standard treatment, the…
- Trial name
- APLAQUINE (NCT02595346)
- Testing
- Hydroxychloroquine
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Rouen
Pancreatic Cancer
PaTcH Study: A Phase 2 Study of Trametinib and Hydroxychloroquine in Patients With Metastatic Refractory Pancreatic Cancer
This study is designed to investigate the means by which cancer resists treatment can be overcome by a combination of an established anticancer drug, trametinib, with hydroxychloroquine.
- Trial name
- PaTcH (NCT05518110)
- Testing
- Trametinib, Hydroxychloroquine
- Where
- 2 sites in Ireland
- Volunteers
- 20 people
- Sponsor
- Cancer Trials Ireland
Metastatic Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer
This phase I trial studies the best dose of hydroxychloroquine when given together with binimetinib in treating patients with KRAS gene mutated pancreatic cancer that has spread to other places in the body (metastatic).
- Trial name
- NCT04132505
- Testing
- Binimetinib, Hydroxychloroquine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Antiphospholipid Syndrome in Pregnancy, Anticoagulants
HYDROxychloroquine in Syndrome Primary AntiPhospholipid
Antiphospholipid syndrome (APS) is defined by thrombosis or obstetric complication (≥ 3 spontaneous miscarriages or fetal death or prematurity <34 weeks gestation-related amenorrhea (SA)) associated with antiphospholipid…
- Trial name
- HYDROSAPL (NCT04275778)
- Testing
- Plaquenil 200Mg Tablet
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis
Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritis
The goal of this randomised, double-blind, placebo-controlled Phase II clinical trial is to assess the safety and effect of of IHL-675A in rheumatoid arthritis patients on pain, and function according to RAPID-3.
- Trial name
- CHAPPII (NCT05942911)
- Testing
- IHL-675A, Cannabidiol, Hydroxychloroquine
- Where
- 10 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Incannex Healthcare Ltd
Erythematotelangiectatic Rosacea
The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined With Tofacitinib and Doxycycline in Chinese Adult Patients With Mild to Moderate Erythematous Telangiectatic Rosacea
The efficacy and safety of anti-inflammation treatment (Hirudoid introduction followed by yellow light therapy) combined with tofacitinib and doxycycline in Chinese adult patients with mild to moderate erythematous telangiectatic…
- Trial name
- NCT07343635
- Testing
- Doxycycline, Hydroxychloroquine, Tofacitinib
- Where
- China
- Volunteers
- 186 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Surfactant Dysfunction
Hydroxychloroquin (HCQ) in chILD of Genetic Defect
The purpose of this proposed research is to investigate the efficacy and safety of hydroxychloroquine sulfate (HCQ, Quensyl) for pediatric ILD(chILD) caused by pulmonary surfactant-associated genes mutations.
- Trial name
- NCT03822780
- Testing
- Hydroxychloroquin
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Children's Hospital of Fudan University
Interstitial Lung Disease, Surfactant Dysfunction
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
The aim of this proposed study is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) in children's interstitial lung diseases(chILD) with genetic causes. This study is a randomized controlled clinical trial.
- Trial name
- NCT04532346
- Testing
- Hydroxychloroquine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Pulmonary Tuberculosis
AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT
Tuberculosis (TB) kills 1.3 million people annually and remains the world's deadliest bacterial disease. The standard four-drug RIPE regimen achieves only 85% cure rates and causes drug-induced hepatotoxicity in 25-37% of…
- Trial name
- AIPH-TB-RCT-P2 (NCT07467252)
- Testing
- Pyrazinamide and Hydroxychloroquine (AI-Optimised), Standard RIPE Regimen (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol)
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Sjogren's Syndrome
Efficacy and Safety of Baricitinib in Sjogren's Syndrome
The investigators had observed that baricitinib was effective and safe in active pSS patients in a pilot study. So the investigators plan to conduct a multi-center, prospective, open-label, randomized study to evaluate the…
- Trial name
- NCT05016297
- Testing
- Baricitinib, Hydroxychloroquine
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Peking Union Medical College Hospital
Alport Syndrome, X-Linked
Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)
This Phase 2 randomized controlled trial will study the safety, tolerability, and efficacy of Hydroxychloroquine in qualified patients with Alport syndrome.
- Trial name
- CHXLAS (NCT04937907)
- Testing
- Hydroxychloroquine Sulfate 100 milligram (mg) Tab, Benazepril hydrochloride 10 milligram (mg) Tab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Children's Hospital
COVID-19
Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19 to determine in-vivo antiviral activity.
- Trial name
- PLATCOV (NCT05041907)
- Testing
- Nirmatrelvir/ritonavir (e.g. PAXLOVID™), Nitazoxanide, Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)
- Where
- 7 sites in Brazil, Laos and 3 more
- Volunteers
- 3,800 people
- Sponsor
- University of Oxford
COVID-19
A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients
This study is a randomized, open label clinical trial to evaluate the safety and efficacy of hydroxychloroquine (HCQ) plus usual care compared to usual care in approximately 350 hospitalized patients diagnosed with COVID-19.
- Trial name
- OAHU-COVID19 (NCT04345692)
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Queen's Medical Center
Resectable Localized Prostate Cancer
HCQ in Resectable Localized Prostate Cancer
This is randomized, double blind, placebo controlled proof of principle (window of opportunity) study of oral hydroxychloroquine in patients with resectable localized prostate cancer.
- Trial name
- NCT06408298
- Testing
- Hydroxychloroquine Sulfate 400Mg Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lionel.D.Lewis, MD
Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma
Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for Advanced Pancreatic Cancer
This phase II trial investigates how well paricalcitol and hydroxychloroquine work when combined with gemcitabine and nab-paclitaxel in treating patients with pancreatic cancer that has spread to other places in the body…
- Conditions
- Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT04524702
- Testing
- Gemcitabine, Hydroxychloroquine, Nab-paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Emory University