Clinical trials: Hydroxychloroquine, completed
COVID-19
Clinical Characteristics and Outcomes of 187 Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)
This case series describes the clinical characteristics, treatment and outcomes of patients with laboratory confirmed COVID-19 admitted to a 35 beds intensive care unit of a tertiary hospital in Northeast Brazil.
- Trial name
- NCT04454372
- Testing
- demographic and clinical data obtained from hospital's electronic medical record.
- Where
- Brazil
- Volunteers
- 187 people
- Sponsor
- Hospital Sao Domingos
COVID-19
Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention
This study is a research project to evaluate the efficacy of hydroxychloroquine for post-exposure prophylaxis and early treatment of Covid-19.
- Trial name
- HCQ4COV19 (NCT04304053)
- Testing
- Treatment and prophylaxis, Standard Public Health measures
- Where
- Spain
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Alport Syndrome, X-Linked
Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)
This Phase 2 randomized controlled trial will study the safety, tolerability, and efficacy of Hydroxychloroquine in qualified patients with Alport syndrome.
- Trial name
- CHXLAS (NCT04937907)
- Testing
- Hydroxychloroquine Sulfate 100 milligram (mg) Tab, Benazepril hydrochloride 10 milligram (mg) Tab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Children's Hospital
COVID-19, Severe Acute Respiratory Syndrome
Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial)
Double blinded randomized clinical trial designed to evaluate the security and efficacy of hydroxychloroquine as treatment for COVID-19 severe respiratory disease.
- Trial name
- HYDRA (NCT04315896)
- Testing
- Hydroxychloroquine
- Where
- Mexico
- Volunteers
- 320 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
COVID-19, Coronavirus Infection
Efficacay of Chloroquine or Hydroxychloroquine in COVID-19 Treatment
Chloroquine or hydroxychloroquine in COVID-19 treatment
- Trial name
- NCT04353336
- Testing
- Chloroquine or Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University
COVID-19
Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19
This study will compare two drugs (hydroxychloroquine and azithromycin) to see if hydroxychloroquine is better than azithromycin in treating hospitalized patients with suspected or confirmed COVID-19.
- Trial name
- HAHPS (NCT04329832)
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Intermountain Health Care, Inc.
Malaria,Falciparum, Anemia in Children
Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT06083688
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine-pyrimethamine-amodiaquine
- Where
- Malawi
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Coronary Artery Disease
Efficacy Study of Hydroxychloroquine to Treat High-risk Coronary Artery Disease.
The purpose of this study is to evaluate whether treated with hydroxychloroquine could improve therapeutic effect for patients with high-risk coronary artery disease.
- Trial name
- CHANGAN (NCT02874287)
- Testing
- Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
COVID, COVID-19
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19
Facing the challenge of finding an efficient treatment for COVID-19, the viral pneumonia caused by the Coronavirus SARS-Cov-2, this study intended to test if Chloroquine or Hydroxychloroquine, two drugs with strong in-vitro…
- Conditions
- COVID, COVID-19, SARS-CoV 2, Coronavirus
- Trial name
- NCT04420247
- Testing
- Chloroquine, Hydroxychloroquine, standard care
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
Arthritis, Rheumatoid
Treatments Against RA and Effect on FDG-PET/CT
In a randomized controlled clinical trial, investigators will compare the effects on [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) from two treatment regimens in rheumatoid arthritis (RA)…
- Trial name
- TARGET (NCT02374021)
- Testing
- Methotrexate, Sulfasalazine, Hydroxychloroquine
- Where
- 31 sites in United States
- Volunteers
- 159 people
- Sponsor
- Brigham and Women's Hospital
Covid19
Public Health Emergency: SOLIDARITY TRIAL Philippines
This study is an adaptive, randomized, open-label, controlled clinical trial utilizing an adaptive design to compare effects of repurposed drugs with local standard of care alone on major inpatient hospital outcomes.
- Trial name
- NCT05024006
- Testing
- Remdesivir, Hydroxychloroquine, Lopinavir / Ritonavir
- Where
- 25 sites in Philippines
- Volunteers
- 1,314 people
- Sponsor
- University of the Philippines
Acute Respiratory Tract Infection, Acute Respiratory Insufficiency
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical…
- Conditions
- Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia, Septic Shock
- Trial name
- NCT04346693
- Testing
- Standard therapy recommended by the Ministry of Health of the Russian Federation., Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection, Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Rheumatoid Arthritis
A Study of Tocilizumab in Combination With DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis
This 2-arm study assessed the safety and efficacy of tocilizumab versus placebo, both in combination with disease modifying antirheumatic drugs (DMARDs), in regard to reduction in signs and symptoms, in patients with moderate to…
- Trial name
- ROSE (NCT00531817)
- Testing
- Tocilizumab, Permitted DMARDs
- Where
- 157 sites in United States, Puerto Rico
- Volunteers
- 619 people
- Sponsor
- Hoffmann-La Roche
Brain and Central Nervous System Tumors
Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00486603
- Testing
- hydroxychloroquine, temozolomide, pharmacological study
- Where
- 9 sites in United States
- Volunteers
- 92 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Severe Acute Respiratory Syndrome Coronavirus 2
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy Adult Volunteers
This study is 'A Randomized Phase 1 Double Blind Placebo Controlled, Single-Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy…
- Trial name
- NCT04461353
- Testing
- Aerolized Hydroxychloroquine Sulfate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pulmoquine Therapeutics, Inc
Coronavirus Infection, Coronavirus
University of Utah COVID-19 Hydrochloroquine Trial
A novel coronavirus, SARS-CoV-2, is responsible for a rapidly spreading pandemic that has reached 160 countries, infecting over 500,000 individuals and killing more than 24,000 people.
- Conditions
- Coronavirus Infection, Coronavirus, Infectious Disease
- Trial name
- NCT04342169
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- University of Utah
Lupus Erythematosus, Systemic
A Phase 2a, Efficacy and Safety Study of Ustekinumab in Systemic Lupus Erythematosus
The purpose of this study is to evaluate the efficacy of ustekinumab as measured by a reduction in disease activity for subjects with active Active Systemic Lupus Erythematosus (SLE - chronic disorder of connective tissue in…
- Trial name
- NCT02349061
- Testing
- Ustekinumab IV, Ustekinumab SC, Concomitant Medication
- Where
- 43 sites in United States, Argentina and 7 more
- Volunteers
- 102 people
- Sponsor
- Janssen Research & Development, LLC
Lymphangioleiomyomatosis
Safety Study of Sirolimus and Hydroxychloroquine in Women With Lymphangioleiomyomatosis
Specific Aim 1: To investigate whether, in Lymphangioleiomyomatosis (LAM) patients, the combination of sirolimus and hydroxychloroquine is safe and well tolerated Specific Aim 2: To investigate whether, in LAM patients, 6 months…
- Trial name
- SAIL (NCT01687179)
- Testing
- "Sirolimus" and "Hydroxychloroquine" 200 mg, "Sirolimus" and "Hydroxychloroquine" 400 mg
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Covid19, Hydroxychloroquine
Rapid Development and Implementation of a Remote ECG-monitored Prospective Randomized Clinical Trial During a Pandemic: Hydroxychloroquine Prophylaxis in COVID-19 Household Contacts
organizing an entirely no in-person contact clinical trial is feasible during a 22 COVID-19 pandemic 23 Remote smartphone 6-lead ECG monitoring is possible even in a group unfamiliar 24 with the technology 25 Hydroxychloroquine…
- Conditions
- Covid19, Hydroxychloroquine, Coronavirus Infection, Transmission
- Trial name
- NCT04652648
- Testing
- Hydroxychloroquine
- Where
- 3 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bryn Mawr Hospital
Immune Thrombocytopenia, Systemic Lupus Erythematosus
Retrospective Analysis of the Safety and Efficacy of Hydroxychloroquine in Immune Thrombocytopenia
Retrospective study of the safety and efficacy of hydroxychloroquine among patients with immune Thrombopenia (ITP).
- Trial name
- HCQITP (NCT01549184)
- Volunteers
- 40 people
- Sponsor
- Henri Mondor University Hospital