Clinical trials: Insulin, completed
Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Glulisine in Type 1 Diabetes Mellitus
To evaluate non-inferiority in the efficacy of HMR1964 as compared with Insulin lispro in terms of the change in HbA1C from baseline to endpoint. To compare the safety of HMR1964 with insulin lispro.
- Trial name
- NCT00290979
- Testing
- insulin glulisine
- Where
- Japan
- Volunteers
- 250 people
- Sponsor
- Sanofi
Respiratory Distress Syndrome, Adult, Sepsis
Early Insulin and Development of ARDS
Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Symptoms usually develop within 24 to 48 hours of an original injury or illness, and people with…
- Conditions
- Respiratory Distress Syndrome, Adult, Sepsis, Hyperglycemia
- Trial name
- NCT00605696
- Testing
- Insulin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus
Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir
In this study we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir).
- Trial name
- NCT00717288
- Testing
- Detemir
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Ohio State University
Sensitivity to Thyroid Hormones, Metabolic Parameters
Effects of Intermittent Fasting on Fatty Liver Disease
Eighty subjects with FLD were recruited from the endocrinology clinic at Beijing Chao-yang Hospital. All of the following inclusion criteria needed to be met: hepatic fat content (HFC) were upper 5.0% evaluated by upper abdominal…
- Conditions
- Sensitivity to Thyroid Hormones, Metabolic Parameters, in Patients With FLD
- Trial name
- NCT04795973
- Testing
- 5:2 intermittent fasting
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Chao Yang Hospital
Type 1 Diabetes
Continuous Glucose Monitoring and Hypoglycemia Unawareness in Type 1 Diabetes
Looking for strict normoglycemia in type 1 diabetes increases the risk of hypoglycemia, exposing to hypoglycemia unawareness. It has been shown that the early correction of hypoglycemia can help recovering the perception of…
- Trial name
- NCT03605979
- Where
- France
- Volunteers
- 11 people
- Sponsor
- CHU de Reims
Diabetes, Diabetes Mellitus, Type 2
Observational Study on Safety and Efficacy of Biphasic Insulin Aspart in Type 2 Diabetes Patients
This study is conducted in Asia. The aim of this observational study is to evaluate the safety profile and clinical effectiveness of using various pre-mixes of Biphasic Insulin Aspart under routine clinical practice conditions in…
- Trial name
- NCT00834262
- Testing
- biphasic insulin aspart 30, biphasic insulin aspart 50, biphasic insulin aspart 70
- Where
- Israel
- Volunteers
- 339 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
Variable Bolus Regimen 1-2-3 for Type 2 Diabetes Mellitus
The purpose of this study is to show the non-inferiority of insulin glulisine administered with 1 meal versus 2 meals versus 3 daily meals, as measured by the change in hemoglobin A1c (HbA1c), from baseline to study week 24.
- Trial name
- NCT00135083
- Testing
- insulin glulisine
- Volunteers
- 347 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1
Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes
The closed-loop delivery system is composed of an insulin pump, a continuous glucose sensor and a dosing algorithm that calculates the insulin dose to infuse based on sensor readings.
- Trial name
- NCT02814123
- Testing
- 24-hour inpatient intervention
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 2
A Study in Adults With Type 2 Diabetes
The main purpose of this study is to compare the effectiveness and safety of LY2963016 versus Lantus in controlling blood sugar levels in combination with two or more oral diabetes medications.
- Trial name
- ELEMENT 2 (NCT01421459)
- Testing
- LY2963016, Lantus, OAMs
- Where
- 62 sites in United States, Czechia and 10 more
- Volunteers
- 759 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin.
The study is aimed at Type 2 Diabetics who are taking Metformin, but whose Diabetes remains poorly controlled. There are two additional medications already in use, Glimepiride and Sitagliptin will be compared to assess levels of…
- Trial name
- MSD-GLP1 (NCT00747383)
- Testing
- Glimepiride, Sitagliptin
- Where
- United Kingdom
- Volunteers
- 74 people
- Sponsor
- The Royal Bournemouth Hospital
Type 1 Diabetes
An 8-Day Initiation of Advanced Hybrid Closed Loop System In Children and Adolescents
One of the available Hybrid closed loop system is MiniMed 670G (Medtronic Diabetes, Northridge, CA, USA), which is indicated for children above 7 years old, adolescents and adults with Type 1 Diabetes.
- Trial name
- NCT04509362
- Testing
- Advanced Hybrid Closed Loop System
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Insulin Resistance, Obesity
Adipose Tissue Response to Overfeeding in Insulin Resistance-Prone vs. Insulin Sensitive Humans
Obesity has become an epidemic worldwide. Data from our laboratory and others demonstrate that most of the excess morbidity from obesity is related to insulin resistance (IR).
- Trial name
- NCT02084641
- Testing
- Over feeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Branched-chain Amino Acid Metabolism, Insulin Sensitivity
Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes
Elevated circulating levels of certain amino acids (the building blocks of protein) are strongly associated with insulin resistance.
- Trial name
- BCAAM-PD (NCT01786941)
- Testing
- Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training, GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Duke University
Impaired Glucose Tolerance
Cognitive Effects of Aerobic Exercise for IGT Adults
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at risk for developing type II diabetes mellitus (T2DM), and to evaluate whether change in insulin sensitivity…
- Trial name
- NCT00220441
- Testing
- Aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Type 2 Diabetes
Low Glycemic Index Diet (With Canola Oil) for Type 2 Diabetics
Healthy individuals with type 2 diabetes will receive intensive counseling on food selection to improve glucose control using either high cereal fiber dietary strategies or low glycemic index foods especially canola oil…
- Trial name
- NCT01348568
- Testing
- low glycemic index diet with canola oil bread, High fiber diet
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- University of Toronto
Diabetes Type 2, Obesity
Does Green Tea Affect Postprandial Glucose, Insulin and Satiety in Healthy Subjects
Green tea consumption could lower the risk of type II diabetes, as suggested by epidemiological studies. There is also evidence from intervention studies that green tea can decrease blood glucose levels and contribute to weight…
- Trial name
- NCT01086189
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Effect of NN1250 in Japanese Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim of this clinical trial is to investigate the effect of NN1250 (insulin degludec) in Japanese subjects with type 1 diabetes.
- Trial name
- NCT01135927
- Testing
- insulin degludec, insulin detemir
- Where
- Japan
- Volunteers
- 22 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Pharmacogenomics of Thiazolidinediones
The purpose of this study is to determine predictors of response to pioglitazone, an anti-diabetic medication. The investigators know from randomized clinical trials that some 30% of patients do not respond to this type of…
- Trial name
- PPAR (NCT01135394)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 1
Pre Transplant Rapamycin Treatment in Islet Transplantation Alone
Numerous changes to the original Edmonton protocol have been proposed in the attempt of improving the still unsatisfactory long-term function of ITA.
- Trial name
- ITA-Rp (NCT01060605)
- Testing
- rapamycin
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- IRCCS San Raffaele
Cystic Fibrosis
Diet, Physical Activity and Glucose Tolerance in Cystic Fibrosis. Exploratory Study.
Background : Diabetes is correlated to an increase in patient morbidity and mortality. The pathophysiology of diabetes is still poorly understood.
- Trial name
- MONA (NCT04249466)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Hospices Civils de Lyon
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