Clinical trials: Insulin, completed
Obesity
Starches Digestion After Obesity Surgery.
Despite an impressive capacity to induce diabetes remissions, the gastric bypass surgery has been associated with the onset of hyperglycemic peaks, which are very intensive and transient, in formally non diabetic patients.
- Trial name
- GLUBYPASS (NCT02789553)
- Testing
- First starch meal then meal with glucose syrup, First meal with glucose syrup then starch meal
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Toulouse
Diabetes, Diabetes Mellitus, Type 2
Safety of NovoMix® 30 or Levemir® for Treatment of Type 2 Diabetics in Macedonia
This study is conducted in Europe. The aim of this observational study is to investigate the incidence of serious adverse drug reactions when using NovoMix® 30 (biphasic insulin aspart 30) or Levemir® (insulin detemir) for…
- Trial name
- NCT00842894
- Testing
- insulin detemir, biphasic insulin aspart 30
- Where
- North Macedonia
- Volunteers
- 3,421 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Disease, Insulin Resistance
Study of Vitamin D3 Supplementation in Patients With Chronic Kidney Disease
The purpose of this study is to evaluate the impact of vitamin D3 supplementation on the insulin resistance in non-diabetic patients with chronic kidney disease (CKD) stages 3-4, vitamin D deficiency/insufficiency and elevated…
- Conditions
- Chronic Kidney Disease, Insulin Resistance, Vitamin D Deficiency
- Trial name
- VitaD-CKD1 (NCT00893451)
- Testing
- cholecalciferol (TillVal-D)
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Sahlgrenska University Hospital
Diabetes Mellitus
Efficacy of Pioglitazone Compared to Glyburide in Treating Subjects With Type 2 Diabetes Mellitus and Mild Cardiac Disease
The purpose of this study is to evaluate the cardiovascular effects of pioglitazone, once daily (QD), versus glyburide when administered to patients with type 2 diabetes mellitus and mild cardiac disease.
- Trial name
- NCT00521742
- Testing
- Pioglitazone, Glyburide
- Volunteers
- 300 people
- Sponsor
- Takeda
Heart Failure, Diabetes Mellitus, Type 2
Efficacy and Safety of Dapagliflozin in Acute Heart Failure
This is a randomized trial of the addition of dapagliflozin to patients with or without type 2 diabetes hospitalized with acute decompensated heart failure (ADHF).
- Trial name
- DICTATE-AHF (NCT04298229)
- Testing
- Dapagliflozin 10 MG, Protocolized Diuretic Therapy
- Where
- 6 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
A Research Study in Saudi Arabia to Understand How the Dose Check App Used With Tresiba Treatment Helps to Control Blood Sugar Level
This study looks at how a mobile based app called 'Dose Check' used along with Tresiba helps to control blood sugar level in participants with type 2 diabetes mellitus.
- Trial name
- DEAL-2 (NCT06153537)
- Testing
- Insulin degludec
- Where
- 14 sites in Saudi Arabia
- Volunteers
- 179 people
- Sponsor
- Novo Nordisk A/S
Aortic Stenosis, Coronary Heart Disease
The Effect of Glucose-Insulin-Potassium Infusion in Patients Undergoing Cardiac Surgery
The purpose of this study is to evaluate the cardioprotective effects of a short term infusion of glucose-insulin-potassium (GIK) during heart surgery.
- Conditions
- Aortic Stenosis, Coronary Heart Disease, Heart Failure
- Trial name
- NCT00788242
- Testing
- Glucose-insulin-potassium
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- Christoph Ellenberger
Glucose Parameters, Triglycerides
Investigating the Effects of Glucodia™ on Glucose Parameters, Triglycerides and Body Weight
This study is investigating the effects of 8 weeks of supplementation with Glucodia™, on glucose parameters, triglycerides and body weight as compared to a placebo.
- Conditions
- Glucose Parameters, Triglycerides, Body Weight
- Trial name
- 14GGHF (NCT02322294)
- Testing
- Glucodia™
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Cystic Fibrosis-related Diabetes
Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes
The aim of this study is to assess the utility of CGMs to determine the optimal method to dose meal-time insulin. The investigators will examine glucose excursions in patients with CF who will dose meal-time rapid-acting insulin…
- Trial name
- NCT04533646
- Testing
- Insulin, Continuous glucose monitor (CGM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jagdeesh Ullal
Type 1 Diabetes Mellitus, Hypoglycemia
FreeStyle Libre FGM During Summer Camp for Children With Type 1 Diabetes
A randomized, double-blinded, single center, parallel design pediatric study, on 45 subjects with type 1 diabetes (T1D), aged six to 15 (inclusive) years, measuring sensor time in glucose values within range 3.9 - 10 mmol/l (70 …
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hyperglycemia
- Trial name
- NCT03182842
- Testing
- FreeStyle Libre FGM, SMBG - Blinded Sensor
- Where
- Slovenia
- Volunteers
- 45 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diabetes Mellitus
Pharmacokinetic and Pharmacodynamic Properties of BIOD-123 and BIOD-125 Compared to Humalog® in Subjects With Type 1 Diabetes Including Assessments of Injection Site Toleration
The primary objective is to assess the speed of absorption of BIOD-123 and BIOD-125 and compare them to Humalog.
- Trial name
- NCT01908894
- Testing
- BIOD-123, BIOD-125, Humalog
- Volunteers
- 12 people
- Sponsor
- Biodel
Type 1 Diabetes Mellitus
IGF-I Induced Muscle Glucose Uptake and Interstitial IGF-I Concentrations
Hormonal disturbances in the GH-IGF-I axis are considered important for the deterioration of glycemic control in T1DM particularly in adolescents.
- Trial name
- NCT01588093
- Testing
- Increlex, 0.9% Saline
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Peter Bang
Type1 Diabetes
Comparative Glucose Clamp Study of Wockhardt's Recombinant Insulin Analog Glargine(Glaritus) With Lantus in T1DM
The aim of this trial is to demonstrate bioequivalence of Glaritus® to Lantus® with regard to its total and to its maximum serum insulin concentrations.
- Trial name
- NCT01357603
- Testing
- Glargine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Wockhardt
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Study Of Rosiglitazone Plus Insulin To Treat Type 2 Diabetes Mellitus Patients
This study is designed to demonstrate that addition of rosiglitazone (4mg) to insulin in Type 2 diabetes mellitus subjects who have not achieved glycemic goals on insulin injections alone is efficacious in terms of improving…
- Trial name
- NCT00349427
- Testing
- Rosiglitazone 4 mg
- Where
- 10 sites in China
- Volunteers
- 256 people
- Sponsor
- GlaxoSmithKline
Diabetes type1
Simple Initiation of Advanced Hybrid Closed Loop System
Background and Aim. The new and advanced hybrid closed loop (AHCL) system MiniMed 780G automatically adjusts basal insulin delivery in addition to automated bolus corrections, based on continuous glucose monitoring (CGM)…
- Trial name
- 780GGS (NCT05069727)
- Testing
- Regular Protocol with advanced carbohydrate counting, Simplified Protocol with fixed carbohydrate content
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Growth Hormone Deficiency
Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates
Study hypothesis: Growth hormone (GH), through its generation of free 'bioavailable' insulin-like growth factor (IGF)-I, can improve insulin sensitivity in adults with GH deficiency.
- Trial name
- NCT00517062
- Testing
- Growth hormone (Genotropin)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose
This study evaluates direct switching vs use of a bridging dose from insulin glargine to insulin degludec in type 1 DM patients.
- Trial name
- GLIDING (NCT04623086)
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Washington
Type 2 Diabetes Mellitus, Non Insulin Dependent, Diabetes Mellitus, Non-Insulin-Dependent
A Study to Test the Safety and Efficacy of Sitagliptin Compared to Glimepiride in Patients With Type 2 Diabetes on a Stable Dose of Metformin (0431-803)(COMPLETED)
A study to see if better control of type 2 diabetes can occur in patients taking a stable dose of metformin when they are also provided either sitagliptin or glimepiride.
- Trial name
- NCT00701090
- Testing
- sitagliptin, Comparator: glimepiride, open-label metformin
- Volunteers
- 1,035 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus Type II
LANN-study: Lantus, Amaryl, Novorapid, Novomix Study
Many diabetics gain weight while on insulin therapy. In this study, we evaluate the efficacy of the combination of glimepiride and short-acting insulin on weight control and glucose control.
- Trial name
- NCT00151697
- Testing
- Novomix 30, Novorapid and Amaryl, Lantus
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Rijnstate Hospital
Obesity
The Role of the Omentum in the Treatment of Morbid Obesity
The purpose of this research is to determine some of the reasons that blood sugar and insulin levels improve after bariatric surgery but before weight loss begins, as well as why people respond differently to weight loss surgery.
- Trial name
- NCT00212160
- Testing
- omentectomy
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
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