Clinical trials: Insulin, completed
Type1 Diabetes Mellitus
Proof of Concept - Identification of Patient-specific Parameters for Bolus Calculators for Type 1 Diabetes
The adoption of bolus calculators has been limited by the slow speed of the current trial and error approach. The goal of this project is to automate the determination of patient specific insulin pump parameters based on current…
- Trial name
- POC-IDENTITY-1 (NCT03414320)
- Testing
- Gathering data
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes, Eating Disorder
Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity
The purpose of the study is to investigate how people with type 1 diabetes experience and manage their diabetes, eating, and weight.
- Trial name
- NCT01513746
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Duke University
Impaired Glucose Tolerance, Hyperinsulinism
Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes
This study investigated any potential associations between two isocaloric diets with different meal frequency (3 meals versus 6 meals) and glycemic control in people at high diabetes risk (lean and overweight/obese women with…
- Conditions
- Impaired Glucose Tolerance, Hyperinsulinism, Poor Glycemic Control, Hyperglycemia
- Trial name
- NCT02248272
- Testing
- Isocaloric diet with 3 meals, Isocaloric diet with 6 meals
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Meropi Kontogianni
Healthy, Healthy Volunteer
Avocado and Postprandial Responses
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.
- Conditions
- Healthy, Healthy Volunteer, Healthy Volunteers, Healthy Adult
- Trial name
- NCT06818032
- Testing
- Negative control, Avocado, Fat and fiber addition
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Type 2 Diabetes
A Clinical Study Comparing the Pharmacokinetics and Pharmacodynamic Characteristics of Insulin Degludec Injection (RD15003) and Insulin Degludec Injection (Tresiba®) in Healthy Subjects
To evaluate the single-dose subcutaneous injection of insulin degludec injection (Tresiba®) listed by Novo Nordisk in China as a reference drug, the insulin degludec injection provided by Dongguan Dongyang Sunshine…
- Trial name
- NCT05576298
- Testing
- Insulin degludec injection, RD15003, Insulin degludec, Tresiba
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Diabetes, Healthy
Bioequivalence of Two Insulin Aspart Formulations (100 U/mL Versus 200 U/mL)
This trial is conducted in Europe. The aim of this trial is to test if there is bioequivalence between the insulin aspart 100 U/mL (U100) formulation and the new insulin aspart 200 U/mL (U200) formulation.
- Trial name
- NCT01530048
- Testing
- insulin aspart
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
Study of Insulin Lispro in Participants With Inadequately Controlled Type 2 Diabetes
Evidence regarding optimal methods of insulin dose adjustment is lacking in the literature. The purpose of this study is to evaluate the efficacy and safety of two approaches to escalate prandial insulin therapy in participants…
- Trial name
- AUTONOMY (NCT01215955)
- Testing
- Insulin lispro, Glargine
- Where
- 76 sites in United States, Argentina and 13 more
- Volunteers
- 1,117 people
- Sponsor
- Eli Lilly and Company
Coronary Heart Disease, Stroke
Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
To investigate long-term effects on cardiovascular mortality/morbidity and renal failure in type 1 diabetes patients former randomized to intensive insulin treatment
- Conditions
- Coronary Heart Disease, Stroke, Renal Failure
- Trial name
- SDIS (NCT02138006)
- Testing
- Intensive insulin treatment, Standard insulin treatment
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Karolinska Institutet
Hypertension, Oxidative Stress
Effect of Antioxidant Supplementation on the Autonomic Balance
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events.
- Conditions
- Hypertension, Oxidative Stress, Autonomic Imbalance, Insulin Resistance
- Trial name
- NCT03510221
- Testing
- Antioxidants capsules
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type 1 Diabetes Mellitus
The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With T1DM
This study will enroll eligible subjects into a long-term safety study (Part B). Japanese male and female patients with T1DM and age 18 to 75 years, with inadequate glycemic control on insulin defined as HbA1c ≥ 7.5% and ≤ 10.5%…
- Trial name
- NCT02582814
- Testing
- Dapagliflozin 5 mg, Dapagliflozin 10mg
- Where
- 24 sites in Japan
- Volunteers
- 151 people
- Sponsor
- AstraZeneca
Diabetes, Diabetes Mellitus, Type 2
The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy
This trial is conducted in Europe, Oceania and the United States of America (USA). The aim of the trial is to investigate the efficacy of insulin degludec/liraglutide in controlling glycaemia in adults with type 2 diabetes…
- Trial name
- DUAL™ III (NCT01676116)
- Testing
- insulin degludec/liraglutide, liraglutide, exenatide
- Where
- 109 sites in United States, Australia and 3 more
- Volunteers
- 438 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.
This trial is conducted in Asia. The aim of the trial is to compare the glycaemic control of Insulin glargine versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in combination with metformin in subjects with…
- Trial name
- NCT00184626
- Testing
- biphasic insulin aspart, insulin glargine, metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Novo Nordisk A/S
Type1 Diabetes Mellitus
Wharton´s Jelly Derived Mesenchymal Stromal Cell Treatment of Adult Patients Diagnosed With Type I Diabetes
To investigate the safety and tolerance after allogeneic infusion of WJMSCs intravenously in adult patients diagnosed with type 1 diabetes.
- Trial name
- NCT03406585
- Testing
- ProTrans: Allogeneic transplantation with WJMSCs
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- NextCell Pharma Ab
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 2 Treated With Insulin
Insulin Use and Respiratory Muscle Strength in Type 2 Diabetes
This study compares breathing function, breathing muscle strength, and recovery after a walking test in adults with type 2 diabetes, based on whether they use insulin.
- Trial name
- NCT07377448
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Bakircay University
Diabetes Mellitus, Type 2
Linagliptin Add-on to Insulin Background Therapy
To evaluate the efficacy and safety of linagliptin compared to placebo when added on to insulin therapy alone or in combination with metformin in Chinese patients with type 2 diabetes mellitus with insufficient glycaemic control
- Trial name
- NCT02897349
- Testing
- linagliptin, background therapy
- Where
- 25 sites in China
- Volunteers
- 206 people
- Sponsor
- Boehringer Ingelheim
Diabetes, Diabetes Mellitus, Type 1
An Observational Study to Assess Safety and Effectiveness of Intravenous NovoRapid® in Hospitalised Subjects
This study is conducted in Asia. The aim of this observational study is to evaluate the side effects profile and benefits of using intravenous insulin aspart infusion in hospitalised subjects under normal clinical practice…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00700648
- Testing
- insulin aspart
- Where
- India
- Volunteers
- 3,024 people
- Sponsor
- Novo Nordisk A/S
Mucopolysaccharidosis I
Safety and Dose Ranging Study of Insulin Receptor MAb-IDUA Fusion Protein in Patients With MPS I
AGT-181 is a fusion protein containing alpha-L-Iduronidase that is intended to deliver the enzyme peripherally and to the brain, when administered intravenously.
- Trial name
- NCT02371226
- Testing
- AGT-181 (HIRMAb-IDUA)
- Where
- 6 sites in United States
- Volunteers
- 3 people
- Sponsor
- ArmaGen, Inc
Metabolic Syndrome, Insulin Resistance
Grains Reduce Adiposity and Improve Nutrition Study
Whole grain intake beneficially affects body weight, body fat and glucose metabolism, and the investigators' previous work has shown that a high whole grain intake significantly reduced body fat in the abdominal region as…
- Trial name
- GRAIN (NCT00924521)
- Testing
- Whole grain diet, Refined grain
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Penn State University
Diabetes Mellitus, Ventricular Dysfunction
Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus
Our investigation studies the role of acute insulin administration on the diabetic heart, its corresponding effective blood-insulin level and the time-course applicability of insulin in a routine clinical setting.
- Trial name
- NCT02962921
- Testing
- Insulin LISPRO intravenous loading
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Rambam Health Care Campus
Metabolic Syndrome
Acute Effects of Dietary Fats and Carbohydrate in Subjects With Metabolic Syndrome
There is increasing evidence suggests that elevated levels of postprandial triacylglycerol (TAG)-rich lipoproteins may promote the development of cardiovascular diseases (CVD).
- Trial name
- NCT01571947
- Testing
- Acute Effects of Fats and Carbohydrate
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board
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