Clinical trials: Intervention Group
Alzheimer Disease, Dementia
Care Coordination System for People With Dementia
Dementia, a chronic disease of aging, is characterized by progressive cognitive decline that interferes with independent functioning.
- Conditions
- Alzheimer Disease, Dementia, Dementia Alzheimers
- Trial name
- NCT04308512
- Testing
- Active Nili device, Passive Nili system
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bijan Najafi, PhD
HIV
Strategic Antiretroviral Therapy and HIV Testing for Youth in Rural Africa
The goal of this study is to evaluate the effect of a combination intervention on long-term HIV viral load (VL) suppression among HIV-infected adolescents and young adults 15-24 years of age.
- Trial name
- NCT03848728
- Testing
- SEARCH Youth combination intervention
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 1,988 people
- Sponsor
- University of California, San Francisco
Chronic Kidney Disease
Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients
The majority of individuals with advanced ESRD have reduced exercise capacity in part due to decreased muscle mass. This leads to a reduced ability to perform daily activities, a greater incidence of falls, and a reduced quality…
- Trial name
- PERFECT (NCT01990495)
- Testing
- Exercise training, Usual Care
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- VA Office of Research and Development
Brain and Central Nervous System Tumors
Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor
Drugs used in chemotherapy, such as vincristine, cisplatin, and cyclophosphamide, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00085202
- Testing
- filgrastim, cisplatin, cyclophosphamide
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 416 people
- Sponsor
- St. Jude Children's Research Hospital
Hypersomnia, Idiopathic Hypersomnia
Clarithromycin for the Treatment of Hypersomnia
The term 'hypersomnia' describes a group of symptoms that includes severe daytime sleepiness and sleeping long periods of time (more than 10 hours per night).
- Conditions
- Hypersomnia, Idiopathic Hypersomnia, Narcolepsy
- Trial name
- NCT01146600
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Lynn Marie Trotti
Vitreomacular Traction
Effects of Pneumatic Vitreolysis on Vitreomacular Traction
Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection to determine if pneumatic vitreolysis (PVL) is effective…
- Trial name
- AG (NCT03647267)
- Testing
- Pneumatic Vitreolysis (C3F8 injection), Observation
- Where
- 41 sites in United States
- Volunteers
- 46 people
- Sponsor
- Jaeb Center for Health Research
Venous Leg Ulcer
VLU Dressing Study
The goal of the study is to investigate the effectiveness of Cutimed Sorbact (Study Device) in modifying bacterial load in venous leg ulcers (VLU).
- Trial name
- NCT03621592
- Testing
- Cutimed® Sorbact®, Acticoat®
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Response Rates
Contacting Authors to Retrieve Individual Patient Data
The objective of this study is to examine the impact of incentivizing authors of RCTs that are eligible for a systematic review and meta-analysis, versus usual contact strategies to obtain original IPD
- Trial name
- NCT02569411
- Testing
- Financial Incentive
- Volunteers
- 129 people
- Sponsor
- Unity Health Toronto
Mild Cognitive Impairment
11C-Acetate PET/CT Imaging As a Biomarker of Amyloid-Induced Neuroinflammation
The proposed study aims to use 11C-acetate position emission tomography/computed tomography (PET/CT) to preliminarily test and validate methods for imaging astrocyte activation as an early indicator of neuroinflammation in…
- Trial name
- NCT02811744
- Testing
- 11C-acetate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Post-ERCP Acute Pancreatitis
Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
This research is being done to see if using a combination of rectal indomethacin and epinephrine spray during endoscopy, can prevent pancreatitis that may occur after ERCP (a type of gastrointestinal endoscopy).
- Trial name
- INDIEH (NCT02116309)
- Testing
- Rectal Indomethacin, Epinephrine
- Where
- 4 sites in United States, India
- Volunteers
- 948 people
- Sponsor
- Johns Hopkins University
Colorectal Cancer
Comparing Interventions to Increase Colorectal Cancer Screening
The purpose of this study is to test different approaches to help people understand the purpose of colorectal cancer (CRC) screening, two screening test options available, and the barriers to screening so they can make informed…
- Trial name
- NCT03200366
- Testing
- Tailored DVD, Patient Navigation
- Where
- 2 sites in United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Indiana University
Moderate to Severe Hypertension
Efficacy and Safety of the Combination of Aliskiren (300 mg) and Amlodipine (10 mg) Compared to Amlodipine (10 mg) Monotherapy in Patients With Moderate to Severe Hypertension
This study will compare the blood pressure (BP) lowering effect of the combination of aliskiren/amlodipine 300/10 mg versus amlodipine 10 mg monotherapy in patients with moderate to severe hypertension by testing the hypothesis…
- Trial name
- NCT00841672
- Testing
- Aliskiren/amlodipine 300/10 mg tablet, Amlodipine 10 mg capsule
- Where
- 6 sites in Germany, Philippines and 4 more
- Volunteers
- 485 people
- Sponsor
- Novartis
Depressive Symptoms, Anxiety
Health Care Workers and Mental Health
The purpose of this proposal is to deploy digital health interventions to bring timely, easily accessible resources and care to address the mental health and well-being needs of HCWs with direct patient care that are experiencing…
- Conditions
- Depressive Symptoms, Anxiety, Well-Being
- Trial name
- NCT05028075
- Testing
- Cobalt +
- Where
- United States
- Volunteers
- 1,275 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Peripheral Artery Disease
Low InTensity Exercise Intervention in PAD
This proposed study will determine whether a home-based exercise intervention that avoids continuous supervision and exercise-related ischemic pain improves walking performance at 52-week follow-up in people with PAD, compared to…
- Trial name
- LITE (NCT02538900)
- Testing
- Exercise, Attention control
- Where
- 4 sites in United States
- Volunteers
- 305 people
- Sponsor
- Northwestern University
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Colorectal Cancer
Navigation From Community to Clinic to Promote CRC Screening in Underserved Populations
The purpose of this study is to test the effectiveness of a two-phase intervention using "community-to-clinic navigators" to guide individuals from an especially hard-to-reach, multicultural, and underinsured population into…
- Trial name
- NCT01853774
- Testing
- Tailored navigation
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Trauma Injury
Developing a Deliberate Practice Intervention to Recalibrate Physician Heuristics in Trauma Triage
The objective of this study is to test the feasibility of using deliberate practice - goal-oriented training in the presence of a coach who can provide personalized, immediate feedback - to increase engagement.
- Trial name
- NCT05168579
- Testing
- Deliberate practice
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Dental Anxiety
Efficacy of an Internet-based Intervention for Dental Anxiety
The overall objective of the activities described in this protocol is to examine the efficacy of the Internet-based intervention in the reduction of dental anxiety in patients seeking dental treatment.
- Trial name
- NCT03680755
- Testing
- Internet-based intervention for dental anxiety
- Where
- United States
- Volunteers
- 503 people
- Sponsor
- Temple University
Siblings, Childhood Cancer
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer
This study aims to address barriers to psychosocial care for siblings of children with cancer by piloting a group-based telehealth program for adolescent siblings of youth with cancer.
- Conditions
- Siblings, Childhood Cancer, Pediatric Cancer, Posttraumatic Stress Disorder
- Trial name
- R03 CA259898 (NCT04889755)
- Testing
- SibACCESS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Chronic Back Pain, Depression
Improving Outcomes for Older Veterans With Chronic Back Pain and Depression
The overarching goal of this study is to develop and evaluate a telephone delivered behavioral change intervention for older Veterans with chronic low back pain (cLBP) and comorbid depression, and to ultimately assess its effect…
- Conditions
- Chronic Back Pain, Depression, Aging
- Trial name
- NCT03896035
- Testing
- Behavioral Intervention Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
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