Clinical trials: Intervention Group
Charcot Joint of Foot
Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy
Charcot neuroarthropathy (CN) is a debilitating disease primarily affecting poorly controlled diabetic patients with peripheral neuropathy.
- Trial name
- NCT03174366
- Testing
- Denosumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Western University of Health Sciences
Obesity Prevention
A Web-Based Healthy Living Training for Promotores
The goal of this clinical trial is to test a new web-based promotora de salud/ community health worker (CHW) training. This training is designed to provide CHWs with the knowledge and skills to effectively implement a healthy…
- Trial name
- NCT06627439
- Testing
- Comadres Saludables, Control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Pain Management
The Efficacy of Thoracoabdominal Nerve Block With Serratus Intercostal Plane and Rectus Sheath Block in Cholecystectomy
Cholecystectomy is a widespread surgical procedure performed worldwide for acute cholecystitis. This operation can be performed using open surgery or laparoscopic techniques.
- Trial name
- NCT06241794
- Testing
- Group M-TAPA, Group Serratus Intercostal Plane Block and Rectus Sheath Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Hitit University
Laceration of Hand, Laceration of Forearm
Suture Repair of Lacerations in the ED: Comparison Between Two Suture Materials
This study aims to determine whether the use of non-absorbable (i.e. nylon) versus absorbable (i.e. chromic gut) sutures in traumatic hand lacerations affects wound healing, patient perception, and development of complications.
- Trial name
- NCT05281666
- Testing
- Absorbable Surgical Gut Suture material, Non-absorbable Nylon Suture Material
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kenneth Taylor, M.D.
Venous Thrombosis
Switching Study From Warfarin to Rivaroxaban
The study objective is to investigate the pharmacodynamics (effects of a drug product) when switching the treatment from warfarin to rivaroxaban.
- Trial name
- NCT01507051
- Testing
- Warfarin (Coumadin), Rivaroxaban (Xarelto, BAY59-7939), Vitamin K (Konakion)
- Where
- 2 sites in Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Bayer
Older Adults, Healthy Aging
danceSing Care Evaluation: Testing the Effectiveness
This pilot randomised controlled trial aims to compare the effectiveness of a 12-week music and movement intervention in older adults in care homes compared to a waitlist control group.
- Conditions
- Older Adults, Healthy Aging, Aging, Quality of Life
- Trial name
- NCT05601102
- Testing
- danceSing Care
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Acute Myeloid Leukemia
GRASPA Treatment for Patients With Acute Myeloblastic Leukemia
The protocol aims at adding GRASPA (L-asparaginase encapsulated in red blood cells, eryaspase) to standard chemotherapy (low-dose cytarabine) to treat patients older than 65 years diagnosed with AML and unfit for intensive…
- Trial name
- ENFORCE (NCT01810705)
- Testing
- GRASPA
- Where
- 21 sites in France
- Volunteers
- 123 people
- Sponsor
- ERYtech Pharma
Obesity, Lifestyle-related Condition
Lifestyle Intervention in Preparation for Pregnancy (LIPP)
Studies evaluating lifestyle intervention in obese women during pregnancy have reported limited success in decreasing excessive gestational weight gain, and have failed to achieve the key outcome of breaking the obesity cycle and…
- Conditions
- Obesity, Lifestyle-related Condition, Macrosomia, Fetal
- Trial name
- NCT03146156
- Testing
- Lifestyle Intervention
- Where
- 4 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Major Depression, Fibromyalgia
A Pilot Study of TMS Effects on Pain and Depression in Patients With Fibromyalgia
In this pilot study, the PI proposes to include 20 African American participants with Fibromyalgia to explore the effect of r TMS on pain and depressive symptoms.
- Trial name
- TMS (NCT00523302)
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Chronic Low-back Pain, Anxiety
EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain
The aim of this randomized controlled trial (RCT) is to assess outcomes for virtual reality therapy (including pain intensity, pain interference, anxiety, depression, physical function, sleep, behavioral skills development…
- Conditions
- Chronic Low-back Pain, Anxiety, Depression
- Trial name
- AVR_HEOR (NCT05263037)
- Testing
- EaseVRx
- Where
- United States
- Volunteers
- 1,093 people
- Sponsor
- AppliedVR Inc.
Depression, Anxiety
Cardiovascular Biomarkers and Quetiapine in Depression and Anxiety Patients
No suitable treatment has been identified to reverse and ideally prevent, the cardiovascular disease risk associated with depression and anxiety.
- Trial name
- NCT00951483
- Testing
- Quetiapine-XR
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Loyola University
Breast Cancer, Gynecologic Cancer
Mindful After Cancer: A Mindfulness-based Therapy Intervention for Sexual Health After Cancer
The objectives of this study are to: 1) adapt a mindfulness-based therapy program designed to help women manage their sexual and body image concerns after cancer (Mindful After Cancer, MAC) to a videoconference format and 2)…
- Trial name
- MAC (NCT04559854)
- Testing
- Mindful After Cancer
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon State University
Plate Waste
OSU Plate Waste Study
Globally, about one-third of edible food is lost or wasted 1. Wasted food depletes resources used to produce the food (as a matter of definition, "produce" includes all activities to distribute, package and prepare food for human…
- Trial name
- NCT02790502
- Testing
- Food Photography Application©
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Primary Aldosteronism, Resistant Hypertension
Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension
Primary aldosteronism (PA) is common but rarely recognized cause of hypertension that carries excess cardiovascular and renal risk and has approved targeted treatments.
- Conditions
- Primary Aldosteronism, Resistant Hypertension, Secondary Hypertension, Hyperaldosteronism
- Trial name
- ALERT-PA (NCT05925569)
- Testing
- Best Practice Advisory Computerized Alert
- Where
- United States
- Volunteers
- 12,501 people
- Sponsor
- Brigham and Women's Hospital
Hypertension With Metabolic Syndrome
Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome
This proof of concept study is designed to evaluate the efficacy and safety of the combination therapy of aliskiren and ramipril as add-on to amlodipine in the treatment of patients with essential hypertension and metabolic…
- Trial name
- ALTO (NCT00542269)
- Testing
- Amlodipine, Aliskiren, Ramipril
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- Novartis
Suicide
Suicide Prevention for Sexual and Gender Minority Youth (Open Trial)
The overarching goal of this study is to develop a suicide prevention program for sexual-and-gender-minority youth and emerging adults.
- Trial name
- NCT05087966
- Testing
- Safety Planning Intervention with Navigation Services
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Obesity
Maintenance After Initiation of Nutrition TrAINing
Obesity is the second leading cause of preventable deaths in the United States and is associated with a wide range of diseases. In people who are obese, weight loss improves blood pressure, dyslipidemia, glycemia, and arthritis…
- Trial name
- MAINTAIN (NCT01357551)
- Testing
- Maintenance intervention
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post-stroke Depression, Post-stroke Aphasia
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
The present parallel-group, single-center, blinded-assessment controlled trial seeks to explore the feasibility - in terms of high completion rates - and potential efficacy of intensive communicative-pragmatic social interaction…
- Trial name
- CONNECT (NCT04318951)
- Testing
- Intensive communicative-pragmatic social interaction., Standard care.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Medicine Greifswald
Heart Failure, Caregivers
Heart Failure Resilience Intervention for Caregivers
Heart failure (HF) patients with supportive caregivers have better physical health, emotional health, and quality of life. But caregivers have an increased risk of caregivers' own worsening health and often feel a sense of burden…
- Trial name
- HEROIC (NCT03963583)
- Testing
- HEROIC
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Acute Respiratory Distress Syndrome, ARDS
Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
Doctors follow a standard ventilator management strategy when making adjustments to the breathing machine to optimize the amount of oxygen into the lungs.
- Trial name
- NCT03793842
- Testing
- Usual care, PEEP titration by EIT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
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