Clinical trials: Ketamine, active
Fibromyalgia
Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia
Previous studies of intravenous ketamine, which is a non-competitive N-methyl-D aspartate receptor antagonist, for fibromyalgia pain relief are limited to three studies.
- Trial name
- NCT06916403
- Testing
- Intravenous Ketamine Infusions
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Wilderman Medical Clinic
Major Depressive Disorder
Mitochondrial Function After Ketamine
The goal of this observational study is to learn about the role of mitochondria in response to S-ketamine. in individuals with Treatment-Resistant Depression. the Research Questions are 1.
- Trial name
- NCT07399756
- Testing
- S (+) Ketamine
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Autism Spectrum Disorder
The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery.
- Trial name
- NPOBCs (NCT07324057)
- Testing
- Intranasal dexmedetomidine, Intranasal Esketamine, saline control
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Fei
Asthma Acute, Exacerbation of Allergic Asthma
Nebulized Ketamine for Severe Asthma Attacks in Children
This is a double-blinded, randomised, placebo-controlled trial enrolling 60 children aged 1 to 13 years with severe asthma exacerbation. All participants will receive standard therapy.
- Trial name
- NCT07728851
- Testing
- Ketamine (1 mg/kg)
- Where
- Oman
- Volunteers
- 60 people
- Sponsor
- Sultan Qaboos University
Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)
A 2×2 Factorial Randomized Controlled Trial for ERCP
To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.
- Trial name
- NCT07584902
- Testing
- Anesthesia induction using propofol+sufentanil, Anesthesia induction using propofol+esketamine, Anesthesia induction using ciprofol+sufentanil
- Volunteers
- 236 people
- Sponsor
- Gang Chen
Major Depressive Disorder, Post Traumatic Stress Disorder
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
This observational registry aims to collect real-world data on ketamine use in psychiatric inpatients within a regional tertiary-reference center.
- Conditions
- Major Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder, Somatoform Disorders
- Trial name
- KetGD (NCT05565352)
- Testing
- Ketamine Hydrochloride
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Medical University of Gdansk
Sedation, Interventional Radiology
Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology
This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation.
- Conditions
- Sedation, Interventional Radiology, Biopsy, Drainage Procedure
- Trial name
- NCT07040163
- Testing
- ketamine, fentanyl, Midazolam
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- CAMC Health System
Vaso-Occlusive Pain Episode in Sickle Cell Disease, Sickle Cell Disease (SCD)
Low Dose Bolus Ketamine For Use In Sickle Cell Pain Crisis
The goal of this study is to learn if Ketamine works more efficiently, as compared to Opioids, for Sickle Cell Pain The main questions it aims to answer are: Does Ketamine lower the number of times participants need to be…
- Trial name
- NCT07682662
- Testing
- Standardized Low-dose bolus IV Ketamine within 30 minutes of arrival and every 1 hour as needed for max of 3 doses., Standard Care (in control arm)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Mississippi Medical Center
Traumatology, Wounds and Injury
Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
Pain is one of the most common reasons for children to attend emergency departments, particularly following traumatic injuries such as fractures, sprains, or contusions.
- Conditions
- Traumatology, Wounds and Injury, Fractures Bone, Analgesia
- Trial name
- SUF-KET-PED (NCT06968546)
- Testing
- Intranasal Sufentanil, Intranasal Ketamine (IN)
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Fondation Lenval
Major Depressive Disorder (MDD)
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
The goal of this clinical trial is to explore if the treatment with ketamine tablets in addition to standard antidepressant therapy can reduce depressive symptoms in adults with Major Depressive Disorder.
- Trial name
- KET01-IIT03 (NCT07396272)
- Testing
- Treatment with Ketamine Hydrochloride Prolonged-Release Tablets
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Daniel Lindqvist
Varicocelectomy
Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial
The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures.
- Trial name
- NCT07214701
- Testing
- Ketamine (0.5 mg/kg), Dexmedetomidine
- Volunteers
- 58 people
- Sponsor
- Assiut University
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Gastrointestinal Disease
Application of Remimazolam Combined With Esketamine in Painless Gastroscopy and Colonoscopy in Elderly Patients
The objective of this clinical trial is to assess the feasibility of the remimazolam combined with esketamine OFA (opioid-free anesthesia) protocol for painless gastroscopy and colonoscopy in elderly patients and to determine if…
- Trial name
- NCT07002801
- Testing
- remimazolam-remifentanil, remimazolam-esketamine
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Harbin Medical University
Endometriosis, Chronic Pelvic Pain Syndrome
Esketamine as Treatment for Chronic Pain Due to Endometriosis: a RCT Study
The goal of this randomized controlled trial is to investigate the effect of esketamine versus placebo on the NRS score for chronic pelvic pain.
- Trial name
- EASYlight (NCT06161805)
- Testing
- Esketamine hydrochloride
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Out-of-hospital Cardiac Arrest (OHCA)
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI).
- Trial name
- KETOHCA (NCT06744361)
- Testing
- esketamine hydrochloride, propofol
- Where
- 2 sites in Denmark
- Volunteers
- 282 people
- Sponsor
- Christian Hassager
Obesity, Pain, Postoperative
Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
The opioid consumption has exploded in the western world, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could…
- Trial name
- OS-PCC (NCT03756961)
- Testing
- Dexmedetomidine, Person-centred care (PCC), Esketamine
- Where
- 2 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Göteborg University
Sedation During GI Endoscopy
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5…
- Trial name
- NCT07423676
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Delayed Sequence Intubation, Rapid Sequence Induction and Intubation
Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols
This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting.
- Conditions
- Delayed Sequence Intubation, Rapid Sequence Induction and Intubation, Intubation, Intubation Complications
- Trial name
- DSI vs RSI (NCT07380763)
- Testing
- Delayed Sequence Intubation, Rapid Sequence Intubation
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
Intravenous Ketamine for Treatment-Resistant Depression
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA…
- Trial name
- G2K (NCT06668571)
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy.
- Trial name
- NCT05303987
- Testing
- Propofol sedation, Dexmedetomidine sedation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Erin Kirkham