Clinical trials: Ketorolac
Pelvic Organ Prolapse, Post Operative Pain
Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy
In the effort to reduce postoperative opioid use, there has been increasing interest in developing multimodal pain regimens to better manage postoperative pain while minimizing opioid use and their subsequent side effects that…
- Trial name
- NCT06309693
- Testing
- Quadratus Lumborum (QL) Block, Enhanced Recovery After Surgical (ERAS) Protocol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Alabama at Birmingham
Degenerative Joint Disease
Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty
To compare two methods of post-operative pain management in patients undergoing total hip arthroplasty. There is a perception that the periarticular injections may not be as effective in controlling post-operative pain.
- Trial name
- DA THA pain (NCT02904993)
- Testing
- L2 paravertebral block, periarticular injection group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Valve Disease, Heart
Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University
Cardiac surgery is associated with post-operative pain which is one of the major problems and remains one of the most controversial issues.
- Conditions
- Coronary Artery Disease, Valve Disease, Heart, Pain, Acute, Pain, Postoperative
- Trial name
- NCT04223219
- Testing
- Fentanyl, Fentanyl, Propofol, Dexmedetomidine, Ketamine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Postoperative Pain, Acute Pain
Analgesic Equivalence of NSAIDs and Tramadol in Acute Postoperative Pain Following Minimally Invasive Surgery
This pilot randomised controlled trial compared the analgesic equivalence of three intravenous premedication regimens - tramadol 150 mg, ketorolac 60 mg, and diclofenac 150 mg - in adult patients undergoing elective minimally…
- Trial name
- NCT07500454
- Testing
- Tramadol, Ketorolac, Diclofenac
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"
Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia
Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department
The opioid epidemic continues to be a major public health crisis in the United States. According to the Center for Disease Control, approximately 8 million Americans reported misusing prescription opioids in 2023, with over 5…
- Conditions
- Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia, Opioid Use During Medical Care
- Trial name
- RELIEF-RC (NCT07536594)
- Testing
- Lidocaine, Morphine 0,1 mg/kg
- Volunteers
- 250 people
- Sponsor
- Loma Linda University
Pain, Postoperative
Pain Management Study
This study aims to better understand the role that narcotic vs. non-narcotic multimodal pain management play in patients' pain following bariatric surgery (Laproscopic Surgery and Robotic Assisted Surgery).
- Trial name
- NCT05231460
- Testing
- Active Comparator: narcotic regimen with TAP block, Active Comparator: narcotic regimen with no TAP block, non-narcotic regimen with TAP block
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Arizona
Nephrolithiasis
Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.
There are two options for postoperative pain management: opioid and non-opioid analgesia. Pain outcomes will be compared in patients undergoing ureteroscopy and percutaneous nephrolithotomy by randomly administering opioid and…
- Trial name
- PO-NOA (NCT03584373)
- Testing
- Ketorolac Oral Tablet [Toradol], Acetaminophen, Oxycodone Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Otitis Media
Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children
The purpose of this study is to compare the efficacy and safety of ketorolac sublingual with fentanyl intranasal used in our hospital for pain control in children undergoing bilateral myringotomy with placement of pressure…
- Trial name
- NCT02653742
- Testing
- Ketorolac, Fentanyl
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Anica Crnkovic
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Effect of RECK in Posterior Spinal Fusion
"RECK" is a combination of local anesthesia medications, used for the purpose of pain control. RECK is an acronym which stands for Ropivacaine, Epinephrine, Clonidine, and Ketorolac.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
- Trial name
- NCT06447194
- Testing
- Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy Volunteers
Study to Determine the Tolerability, Safety and Pharmacokinetics of Ketorolac Tromethamine by Intranasal Administration in Healthy Volunteers
This was a phase 1, open label, multiple dose study in healthy male and female volunteers. Subjects received intranasal ketorolac tromethamine (30 mg) three times daily (t.i.d.) for three days (seven doses in total).
- Trial name
- NCT01363050
- Testing
- Ketorolac tromethamine
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Pain
Enhanced Recovery After Bilateral Reduction Mammaplasty
This single-center, clinical trial is being conducted to determine whether non-narcotic pain regiments are as effective as narcotic-based regiments in reducing post-operative pain in patients undergoing breast reduction in the…
- Trial name
- NCT04558840
- Testing
- Macromastia
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Evaluating Pharmacokinetics of Intranasal Ketorolac, Pain
Pharmacokinetics of Intranasal Ketorolac in Children
Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that is typically given to both adults and children by the intravenous (IV) or intramuscular (IM) route for analgesic purposes.
- Trial name
- NCT02297906
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postoperative Pain
The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA
The purpose of this study is to determine the periarticular multimodal drug injection has more efficacy for controlling pain after TKA than single anaesthetic drug injection.
- Trial name
- TKA (NCT01898052)
- Testing
- single anaesthetic drug, multimodal drug injection
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
Kidney Calculi, Ureteral Calculi
Study of Ketorolac Versus Opioid for Pain After Endoscopy
A double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones.
- Trial name
- SKOPE (NCT03888144)
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pain, Postoperative
Does the Preoperative Midazolam Dose Affect Postoperative Pain?
To investigate whether midazolam has any effect on postoperative pain in outpatient surgery, the investigators will assess the impact of different midazolam doses on pain scores 24h, 7 days and 3 months after ambulatory surgery.
- Trial name
- NCT03534895
- Testing
- Midazolam Injectable Solution, Normal saline, Spinal anesthesia
- Where
- 2 sites in Portugal
- Volunteers
- 168 people
- Sponsor
- Universidade do Porto
Renal Colic
Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic
This study is to see whether the combination regimen of ketorolac and nefopam is superior to that of ketorolac and morphine in controlling ureter stone-related acute flank pain.
- Trial name
- NCT01543165
- Testing
- Ketorolac and nefopam balanced analgesia, Balanced analgesia using ketorolac and morphine, Pain control with single analgesics (ketorolac)
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Seoul National University Hospital
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
General Anesthesia, Children
Effects of Binaural Beats on Inhaled Anesthetic Requirements During General Anesthesia in Pediatric Patients
The hypothesis of this study is that continuously delivering binaural beats with a phase difference corresponding to the slow-delta frequency band during anesthesia in pediatric patients can clinically and significantly reduce…
- Trial name
- NCT06979206
- Testing
- Application of Binarual Beat
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Anesthesia, Surgery
Association Between Clinical Effect of Morphine With PCA After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- PCA-Gene (NCT01233752)
- Testing
- morphine chlorhydrate
- Where
- 2 sites in Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Postoperative Pain
Phase 2 Herniorrhaphy Study for Opioid Elimination
This is a Phase 2, open-label study in subjects undergoing unilateral open inguinal herniorrhaphy.
- Trial name
- NCT03695367
- Testing
- HTX-011, Luer lock applicator, Vial access device
- Where
- 5 sites in United States
- Volunteers
- 63 people
- Sponsor
- Heron Therapeutics