Clinical trials: Losartan
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Osteoarthritis, Knee
Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
This is a prospective, randomized, double-blind, active control clinical trial to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently and in combination, to…
- Trial name
- NCT04815902
- Testing
- Fisetin, Losartan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Steadman Philippon Research Institute
Hamstring Injury
Phase 1/2 Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial of Losartan to Treat Grade II & III Hamstring Strains
The goal of this study is to determine safety and tolerability of Losartan when used for treatment of an acute grade II or III hamstring strain and determining the effect of losartan on recovery of hamstring muscle function.
- Trial name
- NCT02263729
- Testing
- Losartan
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- James J. Irrgang
Diabetes Mellitus, Type 2, Diabetic Kidney Disease
Renohemodynamic Effects of Combined empagliflOzin and LosARtan
Worldwide, diabetic kidney disease (DKD) is the most common cause of chronic and end stage kidney disease. In parallel with the ever-increasing rates of obesity and type 2 diabetes (T2D), the incidence of DKD is expected to…
- Trial name
- RECOLAR (NCT04238702)
- Testing
- Empagliflozin 10 MG, Losartan 50Mg Tab
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Amsterdam UMC, location VUmc
Hypertension
Telmisartan Compared to Losartan + Hydrochlorothiazide in Patients With Mild-to-moderate Essential Hypertension
The general aim and clinical objective of this trial is to determine the effect of telmisartan 80 mg compared to losartan 50 mg + HCTZ (Hydrochlorothiazide) 12.5 mg on reduction of blood pressure (BP) in patients with mild to…
- Trial name
- NCT02183701
- Testing
- Telmisartan, Losartan + Hydrochlorothiazide
- Volunteers
- 715 people
- Sponsor
- Boehringer Ingelheim
SARS-CoV Infection
Do Angiotensin Receptor Blockers Mitigate Progression to Acute Respiratory Distress Syndrome With SARS-CoV-2 Infection
The purpose of this research is to identify whether or not Angiotensin Receptor Blockers (ARB) can halt the progression to respiratory failure requiring transfer into the intensive care unit (ICU), as well as halt mechanical…
- Trial name
- NCT04340557
- Testing
- Losartan
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sharp HealthCare
Essential Hypertension
Olmesartan Medoxomil Versus Losartan Potassium in Patients With Mild to Moderate Essential Hypertension
The purpose of this study is to evaluate the efficacy and safety of olmesartan medoxomil compared with losartan potassium in patients with mild to moderate essential hypertension.
- Trial name
- NCT00856271
- Testing
- olmesartan medoxomil, losartan potassium
- Where
- 5 sites in China
- Volunteers
- 287 people
- Sponsor
- Daiichi Sankyo
Hypertension, Sleep Apnea
Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
Obstructive sleep apnea (OSA) is a highly prevalent condition in hypertensive patients. The renin-angiotension-aldosterone-system (RAAS) has a central role in blood pressure control.
- Trial name
- LosartanPAP (NCT00701428)
- Testing
- Losartan, CPAP
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Skaraborg Hospital
Hypertension
Amlodipine Diabetic Hypertension Efficacy Response Trial
To evaluate the percentage of subjects that reach the diabetic hypertensive blood pressure goal of <130/80 with amlodipine versus placebo in subjects initially treated with quinapril or losartan.
- Trial name
- ADHERE (NCT00159692)
- Testing
- Amlodipine
- Volunteers
- 739 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chronic Kidney Disease, Type 2 Diabetes
Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)
The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease.
- Trial name
- RAPID-CKD (NCT07547878)
- Testing
- Finerenone, Semaglutide, Lotensin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Baylor Research Institute
Hypertension
Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial
The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.
- Trial name
- COMFORT (NCT00670787)
- Testing
- Combination pill of losartan and hydrochlorothiazide
- Where
- Japan
- Volunteers
- 207 people
- Sponsor
- Kyushu University
COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
Long COVID or Postacute sequelae of COVID-19 infection (PASC) are increasingly recognised complications, defined by lingering symptoms, not present prior to the infection, typically persisting for more than 4 weeks.
- Conditions
- COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle, Remodeling, Vascular, Left Ventricular Dysfunction
- Trial name
- MYOFLAME-19 (NCT05619653)
- Testing
- Prednisolone, Losartan
- Where
- 5 sites in Austria, Germany
- Volunteers
- 279 people
- Sponsor
- Valentina Puentmann
Hypertension
Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel…
- Trial name
- NCT02294539
- Testing
- Losartan 50mg/amlodipine 5mg, Losartan 100mg/amlodipine 5mg, Losartan 50mg/Hydrochlorothiazide 12.5mg
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- Chong-Jin Kim
Arthrofibrosis of Knee
Losartan Use to Mitigate Arthrofibrosis Following Total Joint Arthroplasty
The purpose of this study is to determine the effect of Losartan, an Angiotensin II Receptor Blocker (ARB), on the formation development of arthrofibrosis in patients who have had a primary total knee arthroplasty.
- Trial name
- NCT06333522
- Testing
- Losartan
- Where
- United States
- Sponsor
- NYU Langone Health
Hypertension,Essential
An Observational Study to Evaluate Effectiveness and Safety of Amosartan Plus Tablet
This study was to evaluate the therapeutic effect and safety of Amosartan Plus tablet administration in uncontrolled essential hypertension patients.
- Trial name
- NCT05462535
- Testing
- Amosartan Plus Tab.
- Where
- South Korea
- Volunteers
- 4,785 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Healthy Volunteers
The Effect of Losartan on Emotional Processing in Healthy Volunteers
This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.
- Trial name
- NCT03434054
- Testing
- Losartan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Insulin Resistance, Type 2 Diabetes
Effect of Angiotensin Receptor Blockade on Insulin Resistance and Adipose Tissue Cytokines in Type 2 Diabetes
The study aims to investigate the effect of acute angiotensin receptor blockade on insulin action/insulin resistance and expressions of selected adipocytokines in subcutaneous adipose tissue in insulin-resistant subjects with…
- Trial name
- NCT01011062
- Testing
- Hyperinsulinaemia, Losartan, Saline
- Where
- Czechia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Hypertension,Nephropathy
Nighttime Losartan in Continous Ambulatory Peritoneal Dialysis (NVCAPD)
Hypertension is one of the most important independent risk factors for the prognosis of continous ambulatory peritoneal dialysis patients. The incident rate is high and the control rate is low.
- Trial name
- NCT03692013
- Testing
- Losartan
- Volunteers
- 68 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour), Hypertension
Study of Cardiovascular Disease and Obstructive Sleep Apnea
The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure…
- Trial name
- CVD/OSA (NCT01637623)
- Testing
- Losartan, Allopurinol
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Wisconsin, Madison
Hypertension, COVID-19
Coronavirus (COVID-19) ACEi/ARB Investigation
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- CORONACION (NCT04330300)
- Testing
- Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor
- Where
- Ireland
- Volunteers
- 2,414 people
- Sponsor
- National University of Ireland, Galway, Ireland