Clinical trials: Losartan
Pancreatic Ductal Adenocarcinoma
PHL Treatment in Pancreatic Cancer
This proposal will investigate the effect of paricalcitol, hydroxychloroquine, and losartan (PHL) combination of 3 stroma-modifying drugs on pancreatic adenocarcinoma and its stroma.
- Trial name
- NCT05365893
- Testing
- Paricalcitol, Hydroxychloroquine, Losartan, Neoadjuvant therapy and surgery only (Control)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fox Chase Cancer Center
Essential Hypertension
Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations
The principal aim of the study is to demonstrate that Rostafuroxin is able to induce a more pronounced reduction of arterial blood pressure respect to Losartan, in hypertensive patients carrying at least one of the pre-specified…
- Trial name
- NCT01320397
- Testing
- Rostafuroxin, Losartan
- Where
- 26 sites in Ireland, Italy and 1 more
- Volunteers
- 240 people
- Sponsor
- RostaQuo S.p.A.
Hypertension
MK-0954E Study in Participants With Hypertension (MK-0954E-357)
This study is being done to evaluate the efficacy, safety, and tolerability of losartan potassium 50 mg (L50) + hydrochlorothiazide 12.5 mg (H12.5) + amlodipine besylate 5 mg (A5) (MK-0954E).
- Trial name
- NCT01302691
- Testing
- losartan potassium + hydrochlorothiazide + amlodipine besylate (MK-0954E), Losartan potassium, Amlodipine besylate
- Volunteers
- 327 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension
An Open Label Study to Assess the Efficacy, Safety and Tolerability of COZAAR Plus (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) Possibly Titrated up to COZAAR Plus-F (Losartan Potassium 100mg/Hydrochlorothiazide 25mg) in Patients With Essential Hypertension (0954A-325)
Evaluate blood pressure after 6 weeks of treatment with COZAAR plus.
- Trial name
- NCT00449111
- Testing
- MK0954, losartan potassium / Duration of Treatment - 12 weeks
- Volunteers
- 11 people
- Sponsor
- Organon and Co
Hypertension, Resistant to Conventional Therapy, Essential Hypertension
Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension
To test whether the current custom of initiating treatment for hypertension with a single drug is less effective in the short-term than initial combination therapy, and results in the eventual need for comparatively more…
- Trial name
- Pathway 1 (NCT00994617)
- Testing
- Losartan and hydrochlorothiazide, Hydrochlorothiazide switched over with Losartan at 8 weeks
- Where
- 13 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Cambridge
Healthy
The Effects of Losartan on Attention Control: An Eye-tracking Study
The main aim of the present study is to investigate the effects of orally administered Losartan on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking…
- Trial name
- NCT06329050
- Testing
- Losartan
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Post-stroke Pneumonia
Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study
The goal of this retrospective cohort study is to determine if Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs) can lower the risk of post-stroke pneumonia.
- Trial name
- NCT07262710
- Testing
- angiotensin converting enzyme inhibitors, Calcium Channel Blockers, Angiotensin Receptor Blockers
- Volunteers
- 13,656 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Heart Diseases, Diabetes Mellitus, Type 2
NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients
Purpose and rationale The purpose of this study is to evaluate the effect of high dose Renin-Angiotensin System (RAS)-antagonists and beta-blocker treatment for the primary prevention of cardiac events in a population of patients…
- Trial name
- NCT02817360
- Testing
- RAS-antagonist and beta-blocker up-to maximal dosages, RAS-antagonist and beta-blocker none or at stable dose
- Where
- 21 sites in Austria, Netherlands and 3 more
- Volunteers
- 2,400 people
- Sponsor
- Martin Huelsmann
Triple-Negative Breast Cancer (TNBC)
Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy
The objective of this study is to evaluate the safety, feasibility, and preliminary antitumor activity of this multi-component immunotherapy strategy in patients with advanced solid tumors.
- Trial name
- NCT07762703
- Testing
- BreakVax, Ipilimumab 2.5 mg, Pembrolizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- BreakBio Corp
Renal Disorder
Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases (0954-213)
Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases.
- Trial name
- NCT00140985
- Testing
- MK0954, losartan potassium/Duration of Treatment: 20 weeks, Comparator: amlodipine / Duration of Treatment: 20 weeks
- Volunteers
- 97 people
- Sponsor
- Organon and Co
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Hypertension
The Effect of Losartan and Losartan Plus Isosorbide Mononitrate on Central Blood Pressure Measurements (0954-317)
This study will qualify a functional model that can measure central blood pressure and vascular compliance effects through noninvasive means.
- Trial name
- NCT00943852
- Testing
- losartan potassium, Comparator: isosorbide mononitrate (ISMN), Comparator: losartan + ISMN
- Volunteers
- 13 people
- Sponsor
- Organon and Co
Cardiovascular Diseases, Hypertension
Secondhand Tobacco Smoke and Cardiovascular Disease
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic…
- Trial name
- NCT04715568
- Testing
- Losartan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Heart Failure With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri Lanka
The primary objective of this trial is to see if the research team can successfully recruit participants and carry out study related procedures in Sri Lanka.
- Trial name
- NCT06831864
- Testing
- HFrEF Polypill, Comparator Arm
- Where
- 2 sites in Sri Lanka
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Hypertension
A Study to Investigate the Antihypertensive Efficacy of MK0954
After a 4 week placebo period, patients were randomized to Placebo or Losartan 50 mg arms, after 6 weeks non-responders were up titrated to 100 mg losartan for the remaining 6 weeks.
- Trial name
- NCT00887250
- Testing
- losartan potassium, Comparator: losartan
- Volunteers
- 366 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension, Diabetes Mellitus, Type 2
INV-144 Versus Losartan in Hypertension and Type 2 Diabetes Mellitus Patients With Macroalbuminuria
A randomized, double-blind, active control trial to determine the safety, efficacy and pharmacokinetics of INV-144 versus losartan potassium plus placebo in subjects with hypertension and Type 2 diabetes mellitus with nephropathy…
- Trial name
- NCT01398423
- Testing
- Active Control, INV-144
- Where
- 19 sites in United States
- Volunteers
- 88 people
- Sponsor
- InVasc Therapeutics, Inc.
Eosinophilic Esophagitis
An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)
The purpose of this study is to test the safety and effectiveness of Losartan potassium in subjects with eosinophilic esophagitis (EoE) including those with a connective tissue disorder (CTD) and those without a CTD.
- Trial name
- NCT03029091
- Testing
- Losartan Potassium
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
PTSD
Losartan and Memory
This study investigates the effect of a single dose of 50mg losartan vs placebo on BOLD signal during memory encoding.
- Trial name
- NCT05828940
- Testing
- Losartan Potassium
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Losartan Adverse Reaction, Uropathy
The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney
Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction.
- Conditions
- Losartan Adverse Reaction, Uropathy, Uropathy Obstructive
- Trial name
- NCT04278495
- Testing
- Cozaar (Losartan Potassium 25mg)
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Mansoura University
Macroalbuminuric Diabetic Nephropathy
Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus
Chronic kidney disease (CKD)has become a significant health problem worldwide. Strategies to decrease the rate of progression of this disease and reduce the number of patients needing dialysis or renal transplantation are…
- Trial name
- NCT00419835
- Testing
- enalapril, losartan
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo