Clinical trials: Losartan
Diabetic Nephropathy
Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy?
The severity of the diabetic nephropathy is proportional to proteinuria rate and degree of renal interstitial fibrosis. Despite many treatments available today, diabetic nephropathy is responsible for a quarter of cases of…
- Trial name
- NCT02768948
- Testing
- telmisartan during 6 months, Losartan during 6 months, blood sample
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
COVID-19, Cardiovascular Diseases
The COVID-RASi Trial (COVID-19)
The COVID-RASi study is an international randomized clinical trial that will evaluate the potential benefit of angiotensin modulators on clinical outcomes, in COVID-19 patients.
- Trial name
- NCT04591210
- Testing
- Angiotensin converting enzyme inhibitor, Angiotensin II Receptor Blockers
- Where
- 31 sites in Brazil, Canada and 1 more
- Volunteers
- 372 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hypertension
Impact of MK-0954A on Uric Acid in the Management of Hypertension (MK-0954A-366)
This was a retrospective, chart review, observational study to assess the effect of MK-0954A (losartan potassium 50 mg + hydrochlorothiazide 12.5 mg [Hyzaar(R)]) treatment for a period of at least three months on serum uric acid…
- Trial name
- NCT01368185
- Volunteers
- 1,705 people
- Sponsor
- Organon and Co
Covid-19
Coronavirus Response - Active Support for Hospitalised Covid-19 Patients
The CRASH-19 trial is a multinational, open-label, factorial, randomised trial in adults hospitalised with suspected or confirmed acute COVID-19 infection.
- Trial name
- CRASH-19 (NCT04343001)
- Testing
- Aspirin, Losartan, Simvastatin
- Where
- 2 sites in Nigeria, Pakistan
- Sponsor
- London School of Hygiene and Tropical Medicine
Newly-diagnosed Glioblastoma
Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma
To assess the efficacy of an Angiotensin-II inhibitor (Losartan) to reduce peritumoral edema in newly diagnosed glioblastoma patients.
- Trial name
- ASTER (NCT01805453)
- Testing
- Losartan
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Study of Losartan in Pediatric Patients With Hypertension (MK-0954-337)
This study will explore the dose-response of losartan as well as the safety and tolerability in children from 6 months to 6 years of age.
- Trial name
- NCT00756938
- Testing
- losartan potassium
- Volunteers
- 101 people
- Sponsor
- Organon and Co
Keloid
Ethosomal Gel Bearing Losartan 5% for Keloid Treatment
The objectives are to compare the efficacy of pre and post-treatment and between 5% losartan potassium loaded in ethosomal gel and 10 mg/ml triamcinolone acetonide injection based on the indicator score of The patient and…
- Trial name
- NCT05893108
- Testing
- Ethosomal gel bearing losartan 5%, triamcinolone acetonide 10 mg/ml
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Yuni Eka Anggraini
Pancreatic Cancer
Radiation w/FOLFIRINOX-Losartan for Pancreatic Cancer
This is a Phase II clinical trial, which tests the safety and effectiveness of an investigational combination of drugs to learn whether the combination of drugs works in treating a specific cancer.
- Trial name
- NCT01821729
- Testing
- FOLFIRINOX, Losartan, Proton Beam Radiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis
Losartan and Inflammation in Cystic Fibrosis
The purpose of the study is to examine if a specific drug called losartan (Cozaar ®), generally used to treat high blood pressure and to protect kidneys from damage in patients suffering from Diabetes Mellitus, will have any…
- Trial name
- NCT03206788
- Testing
- Losartan
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Miami
Chronic Kidney Disease, Hypertension
Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)
This study determined the optimal starting dose of patiromer in treating hyperkalemia in participants with hypertension and diabetic nephropathy who were already receiving ACEI and/or ARB drugs, with or without spironolactone.
- Conditions
- Chronic Kidney Disease, Hypertension, Hyperkalemia
- Trial name
- AMETHYST-DN (NCT01371747)
- Testing
- patiromer, losartan, spironolactone
- Where
- 43 sites in Croatia, Georgia and 3 more
- Volunteers
- 324 people
- Sponsor
- Relypsa, Inc.
Essential Hypertension
Olmesartan Medoxomil Versus Losartan in Patients With Hypertension
The purpose of this study is to determine the efficacy and safety of oral administration of olmesartan medoxomil compared to losartan in subjects with mild to moderate hypertension.
- Trial name
- NCT00857285
- Testing
- olmesartan medoxomil, losartan potassium
- Where
- 3 sites in Taiwan
- Volunteers
- 130 people
- Sponsor
- Daiichi Sankyo
Hypertension, Coronary Arterial Disease
Comparative Effectiveness of Dual Antihypertensive Regimens in Patients After Percutaneous Coronary Intervention
This prospective randomized open-label study aims to compare the effectiveness of two dual antihypertensive therapy regimens in patients with arterial hypertension and coronary artery disease after elective percutaneous coronary…
- Conditions
- Hypertension, Coronary Arterial Disease, Percutaneous Coronary Intervention
- Trial name
- EDAM (NCT07683585)
- Testing
- Losartan + Hydrochlorothiazide, Amlodipine + Azilsartan
- Where
- Russia
- Volunteers
- 207 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Hypertension
Cozaar XQ Re-examination Study (MK-0954-349)
This survey is conducted for preparing application material for re-examination under the Pharmaceutical Affairs Law and its Enforcement Regulation; its aim is to reconfirm the clinical usefulness of COZAAR XQ through collecting…
- Trial name
- NCT01041807
- Testing
- amlodipine/losartan
- Volunteers
- 669 people
- Sponsor
- Organon and Co
Hypertension
Transforming Hypertension Treatment in Nigeria Using a Type II Hybrid, Interrupted Time Series Design
The purpose of the Transforming Hypertension Treatment in Nigeria Program is to improve awareness, treatment, and control of hypertension in Nigeria through the adaptation, implementation, and evaluation of the effectiveness and…
- Trial name
- HTN (NCT04158154)
- Testing
- Evidence-based fixed-dose combination protocol based treatment
- Where
- 60 sites in Nigeria
- Volunteers
- 21,922 people
- Sponsor
- Washington University School of Medicine
Hypertension
Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients
1. Study name: Efficacy and safety of a single-pill fixed combination of sufficient losartan/hydrochlorothiazide in Chinese hypertensive patients (FOCUS) 2.
- Trial name
- NCT03946514
- Testing
- losartan/hydrochlorothiazide, amlodipine/hydrochlorothiazide
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy
The Pharmacokinetic Interaction Between Amlodipine and Losartan
This clinical trial aims to assess the pharmacokinetic interaction between amlodipine and losartan in healthy male subjects.
- Trial name
- NCT03912285
- Testing
- Amlodipine10mg, Losartan potassium 100mg, Amlodipine plus Losartan
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Hypertension(HTN)
Pharmacokinetic Interaction Between HGP0904, HGP0608 and HGP1405
The purpose of this study is to investigate the pharmacokinetic interaction and safety between HGP0904, HGP0608 and HGP1405 when administered alone and in combination in healthy male volunteers
- Trial name
- NCT02387554
- Testing
- HGP0904, HGP0608, HGP1405
- Where
- South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Pre-hypertension, Pre-diabetes
Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
This randomized, double-blind, parallel group, two-centre pilot study will test the hypothesis that subjects who are otherwise healthy but fulfill the criteria for a diagnosis of pre-hypertension and pre-diabetes will have…
- Trial name
- NCT00388388
- Testing
- losartan, hydrochlorothiazide
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
COPD, Emphysema
Efficacy of Losartan in Preventing Progression of COPD
Evidence in animals shows that losartan can prevent or reverse inflammation and lung damage due to smoking. The goal of this study is to determine whether this drug which is also used to treat hypertension can stabilize or…
- Conditions
- COPD, Emphysema, Chronic Bronchitis, Smoking
- Trial name
- NCT00720226
- Testing
- Losartan
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Johns Hopkins University
Hypertension, Pharmacogenetics
A Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
Blood pressure variation and the risk of essential hypertension have an important genetic component. In most cases susceptibility to essential hypertension is likely determined by the action of more than one gene.
- Trial name
- GENRES (NCT03276598)
- Testing
- Amlodipine, Bisoprolol, Hydrochlorothiazide
- Where
- Finland
- Volunteers
- 233 people
- Sponsor
- Helsinki University Central Hospital