Clinical trials: Losartan
Precancerous Condition
Losartan in Treating Patients With Idiopathic Pulmonary Fibrosis
RATIONALE: Losartan may be effective in treating patients with idiopathic pulmonary fibrosis. PURPOSE: This clinical trial is studying the side effects of losartan and to see how well it works in treating patients with idiopathic…
- Trial name
- NCT00879879
- Testing
- losartan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Hypertension
Antihypertensive Effect of Different Doses of Rostafuroxin in Comparison With Losartan
The principal aim of the study is to demonstrate that Rostafuroxin is able to induce a more pronounced reduction of arterial blood pressure respect to Losartan, in hypertensive patients carrying at least one of the pre-specified…
- Trial name
- NCT03217825
- Testing
- Rostafuroxin, Losartan
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Windtree Therapeutics
Multi-ligament Knee Injury
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events.
- Trial name
- LION (NCT06933706)
- Testing
- losartan 25 mg
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Hypertension
Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients
The aim of this study is to evaluate the effect of lacidipine and losartan in elderly hypertensive patients on reducing the 24 hour systolic BP variability, which is one of the potential parameter to consider in treating elderly…
- Trial name
- NCT00533858
- Testing
- lacidipine (4 mg) or losartan (50 mg)
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Proteinuria
An Extension Study Designed to Assess Effects of Losartan on Proteinuria in Pediatric Populations (MK-0954-326 AM1,EXT1(AM2))
The purpose of this study is to evaluate the effects of losartan on proteinuria in pediatric patients.
- Trial name
- NCT00568178
- Testing
- Losartan Potassium, Comparator: amlodipine besylate
- Volunteers
- 306 people
- Sponsor
- Organon and Co
Hypertension
Clinical Efficacy and Safety Evaluation of HCP1904-2 in Essential Hypertension Patients
The purpose of this study is to evaluate of efficacy and safety of HCP1904-2 and RLD2001-2 alone in patients with essential hypertension inadequately controlled on RLD2001-2 monotherapy.
- Trial name
- NCT04830449
- Testing
- HCP1904-2, RLD2001-2
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Essential Hypertension
Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
This study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide.
- Trial name
- NCT01198249
- Testing
- multiple dose, crossover study between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Renal Failure, Left Ventricular Hypertrophy
Attenuation of Cardiac Effects of Arteriovenous Fistula Creation With Losartan
The primary objective is to determine if the use of losartan, an angiotensin II receptor blocker, can attenuate left ventricular hypertrophy, independent of its antihypertensive effects, in patients with near end stage chronic…
- Trial name
- NCT00602004
- Testing
- losartan
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Melbourne Health
Chronic Kidney Disease
The Canadian Prevention of Renal and Cardiovascular Endpoints Trial
Advanced kidney disease with it's associated heart and blood vessel problems are becoming more frequent. These problems markedly affect length and quality of life and cost a lot to treat.
- Trial name
- CanPrevent (NCT00231803)
- Testing
- Combined CKD and CVD Prevention, Cardiovascular Disease prevention, Treatment of Chronic Kidney Disease complications
- Where
- 5 sites in Canada
- Volunteers
- 474 people
- Sponsor
- Brendan Barrett
SARS-CoV-2 Infection
COVID MED Trial - Comparison Of Therapeutics for Hospitalized Patients Infected With COVID-19
In a randomized, double-blind, placebo-controlled, multi-center, Phase 2-like, investigator-directed trial, hospitalized adult patients with laboratory confirmed SARS-CoV-2 infection meeting inclusion and exclusion criteria, will…
- Trial name
- COVIDMED (NCT04328012)
- Testing
- Losartan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bassett Healthcare
Sarcopenia
A Study of Muscle Strength Maintenance in Older Adults
This research study is being done to see whether losartan can prevent the decrease in strength associated with aging. Muscle loss is associated with aging and has multiple symptoms such as weakness, slowness, and fatigue…
- Trial name
- NCT01989793
- Testing
- Losartan
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Lung Cancer, Atrial Fibrillation
PREvention of Atrial Fibrillation in patientS Undergoing thorAcic surGEry for Lung Cancer
The aim of this study is to assess whether prophylactic treatment with metoprolol or losartan is able to reduce the incidence of atrial fibrillation (AF) in patients undergoing thoracic surgery for lung cancer, showing elevated…
- Trial name
- PRESAGE (NCT01281787)
- Testing
- Metoprolol, Losartan
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- European Institute of Oncology
Healthy
Determinants of Warfarin Metabolism
The anticoagulant effect of warfarin varies greatly among individuals. Some of this variability is attributed to differences in the activity of CYP2C9, the predominant enzyme involved in the metabolism of S-warfarin.
- Trial name
- NCT00162474
- Testing
- Warfarin, Phenytoin, Losartan & Hydrochlorothiazide
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Healthy
Bioequivalence Study of Losartan Potassium (100 mg Tablet) [Test Formulation, Torrent Pharmaceuticals Ltd., India] Versus Cozaar® (100 mg Tablet) [Reference Formulation, Merck & Co. Inc., USA] in Healthy Human Volunteers Under Fed Condition
Objective: compare the single dose bioavailability of Torrent's Losartan Potassium Tablets 1 × 100 mg and Cozaar® Tablets 1 × 100 mg of Merck \& Co., Inc.
- Trial name
- NCT01218698
- Testing
- Losartan Potassium Tablets
- Where
- India
- Sponsor
- Torrent Pharmaceuticals Limited
Hypertension
A Study of the Pharmacokinetics and Pharmacodynamics of MK1809 (1809-001)(COMPLETED)
The goal of this study is to identify at least one safe and well tolerated dose of MK1809 that has similar pharmacokinetic qualities as 100 mg losartan.
- Trial name
- NCT01033318
- Testing
- MK1809, Comparator: Losartan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension
Efficacy and Safety of Telmisartan and Losartan in Primary Hypertension
Using Losartan as a comparator, to evaluate the efficacy and safety of telmisartan in the treatment of the mild to moderate primary hypertension patients in China
- Trial name
- NCT02269176
- Testing
- Low dose of telmisartan, High dose of telmisartan, Low dose of losartan
- Volunteers
- 330 people
- Sponsor
- Boehringer Ingelheim
Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease
Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)
The purpose of this study is to evaluate the efficacy of rosiglitazone alone compared with rosiglitazone plus metformin or rosiglitazone plus losartan in the treatment of biopsy proven nonalcoholic steatohepatitis (NASH).
- Trial name
- NCT00699036
- Testing
- avandia, metformin, losartan
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Brooke Army Medical Center
Memory, Long-Term, Memory, Short-Term
Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects
This project aims at identifying novel pharmacological targets for the treatment of memory disorders.
- Trial name
- LoDi-Basel (NCT01321021)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Healthy
Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers
The purpose of this study is to evaluate the possibility of drug interactions before and after taking red ginseng or fermented-red ginseng by estimating metabolic rate of indicator drugs for cytochrome P450 and P-glycoprotein.
- Trial name
- NCT02056743
- Testing
- CYP cocktail, Fexofenadine 30mg, Red ginseng
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Remission From Stage D Heart Failure
The purpose of this study is to determine the proportion of subjects who have sufficient improvement in ventricular function after undergoing a standardized Left Ventricular Assist Device (LVAD) plus pharmacologic recovery…
- Trial name
- RESTAGE-HF (NCT01774656)
- Testing
- Pharmacological Treatment
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Louisville