Clinical trials: Losartan
Chronic Renal Failure, Hemodialysis
Effects of Shenkang Decoction on Creatinine and Blood Urea Nitrogen in Chronic Renal Failure Hemodialysis Patients
To explore the clinical effect of Shenkang Decoction in chronic renal failure (CRF) patients with hemodialysis (HD).
- Trial name
- NCT05631782
- Testing
- Shenkang decoction
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First People's Hospital of Zunyi
Obesity, Chronic Kidney Diseases
Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease
The goal of this clinical trial is to exploring the changes in 24-hour urinary protein and renal function in obese patients with kidney disease after the application of sodium glucose cotransporter 2 inhibitors (SGLT2i) and…
- Trial name
- NCT06344247
- Testing
- RAS inhibitors：Losartan®️/Valsartan®️, dapagliflozin：Forxiga®️, simagliptin：Forxiga®️
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
Glomerulonephritis, Immunoglobulin A Nephropathy
Multicentre Clinical Study to Evaluate the Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy.
Idiopathic immunoglobulin A nephropathy (IgAN) is the most common biopsy-proven glomerulonephritis in the world. Approximately 40% of IgAN patients reach end-stage kidney disease (ESKD) 20 years after their kidney biopsy.
- Trial name
- CLIgAN (NCT04662723)
- Testing
- Corticosteroid, Renin-angiotensin sytem blockers, Sodium-glucose cotransporter 2 inhibitor
- Where
- 2 sites in Italy
- Volunteers
- 878 people
- Sponsor
- Fondazione Schena
Hypertension
Telmisartan With or Without Hydrochlorothiazide (HCTZ) Compared With Losartan With or Without HCTZ in Mild to Moderate Hypertensive Patients
Study to assess the efficacy of telmisartan 40-80 mg once daily compared with losartan 50-100 mg once daily in hypertensive patients evaluated by change from baseline in diastolic blood pressure (DBP) during the last 6 hours of…
- Trial name
- NCT02172586
- Testing
- Telmisartan, Losartan, Hydrochlorothiazide
- Volunteers
- 363 people
- Sponsor
- Boehringer Ingelheim
HIV Infection, HIV Infections
Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV
This study was designed to test the hypothesis that treatment of HIV infected subjects with losartan, an agent with specific anti-inflammatory and anti-fibrotic actions, will: 1. reverse existing lymphoid tissue fibrosis, 2.
- Trial name
- NCT01852942
- Testing
- Losartan
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hypertension
Clinical Study to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Hypertension Patients
The purpose of this study is to evaluate the antihypertensive efficacy and safety of Fimasartan (BR-A-657•K) 60 mg~120 mg in patients with mild to moderate essential hypertension.
- Trial name
- NCT00922480
- Testing
- Fimasartan, Losartan (Control)
- Volunteers
- 506 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension
Comparison of Blood Pressure Lowering Effect Between Fimasartan and Losartan
Comparison of blood pressure lowering effect between Fimasartan and Losartan in the hypertensive patient during night and early morning time
- Trial name
- NCT02958631
- Testing
- Fimasartan, Losartan
- Volunteers
- 40 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Carcinoma, Hepatocellular
Exploration of Postoperative Adjuvant Therapy for HCC Patients With Positive TB
Hepatocellular carcinoma (HCC) is one of the most common types of primary liver cancer worldwide, characterized by complex and variable disease progression and significant treatment challenges.
- Trial name
- NCT07160361
- Testing
- Lenvatinib + losartan
- Volunteers
- 56 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Herb-drug Interactions
Effects of Kudzu Root (Gegen) on Drug-Metabolizing Enzymes and Blood Clotting in Healthy Volunteers
Purpose: The purpose of this study is to understand how the traditional herbal medicine kudzu root (Gegen, Radix Puerariae lobatae) affects the activity of drug metabolizing enzymes in the body, and whether this could lead to…
- Trial name
- NCT07823140
- Testing
- Arm 1: Radix Puerariae lobatae (Gegen), Arm 1: Six-probe drug cocktail, Arm 2: Radix Puerariae lobatae (Gegen)
- Where
- Hong Kong
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Ischemic Stroke
The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
- Trial name
- NCT00754429
- Testing
- losartan, amlodipine
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hypertension
A Study to Investigate the Efficacy and Safety of Different Doses of Losartan Potassium (MK0954-011)
The purpose of this study was to compare the antihypertensive efficacy of different doses of losartan compared to placebo and enalapril, in patients with supine diastolic blood pressure of 100-115 mmHg.
- Trial name
- NCT00882440
- Testing
- losartan potassium, Enalapril
- Volunteers
- 576 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer
Camrelizumab in Combination With PLD and Losartan in Patients With TNBC Who Have Received ≦ 1 Line of Chemotherapy
This is a phase II, single-arm, multi-center, prospective clinical study of camrelizumab in combination with liposomal doxorubicin and losartan in patients with advanced or locally advanced triple-negative breast cancer who had…
- Trial name
- NCT05097248
- Testing
- Camrelizumab, Liposomal Doxorubicin, Losartan
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypertension, Diabetes Mellitus
Comparison of Amlodipine and Aliskiren in Diabetic Hypertensive Patient With Blood Pressure Not Controlled by Losartan
Assess if aliskiren is capable of enhancing vascular stiffness and endothelial function and compare theses effects and renin activity and concentration to those obtained with a calcium channel blocker, amlodipine, in patients…
- Trial name
- NCT01409408
- Testing
- Aliskiren, Amlodipine
- Where
- Brazil
- Sponsor
- Hospital Universitario Pedro Ernesto
Platinum Resistant Ovarian Cancer
Losartan and Paclitaxel in Platinum Resistant Ovarian Cancer
The purpose of this Phase II study is to measure the effects of a combination of study drugs, losartan and paclitaxel, on platinum resistant ovarian cancer.
- Trial name
- NCT07265739
- Testing
- losartan, Paclitaxel
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Mild to Severe Hypertension
MK0954A-264 Filter Study (0954A-264)(COMPLETED)
To compare the blood pressure lowering efficacy, safety and tolerability of a combination drug to a single drug taken once daily in patients with uncontrolled blood pressure following a 4-week filter on the single therapy product.
- Trial name
- NCT00307060
- Testing
- MK0954A, hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 6 weeks, losartan / Duration of Treatment: 6 weeks
- Volunteers
- 274 people
- Sponsor
- Organon and Co
Type 2 Diabetes, High Blood Pressure
Polypill for Prevention of Cardiomyopathy
This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score.
- Trial name
- PolyPreventHF (NCT06143566)
- Testing
- Polypill, Combined prescription of the individual medications
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Adhesive Capsulitis of Shoulder
Investigation of the Effectiveness of Exercise and Anti-Fibrotic Approaches in Frozen Shoulder
The purpose of this clinical study is to investigate the efficacy of losartan as an antifibrotic approach in addition to a physiotherapy program in patients diagnosed with frozen shoulder.
- Trial name
- NCT07513350
- Testing
- Patient Education, Shoulder Exercise Therapy, Losartan
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istanbul University
Possible Interaction Between Losartan and Cephalexin, Healthy
The Effect of Losartan on Cephalexin
The goal of this clinical trial is to investigate the effects of the blood pressure-lowering drug losartan on the blood levels and urinary excretion of the antibiotic cephalexin during simultaneous and staggered ingestion in…
- Trial name
- KEFALOS (NCT07300670)
- Testing
- losartan, cephalexin
- Where
- Finland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Aleksi Tornio
Eosinophilic Esophagitis, Connective Tissue Disorders
Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD
The purpose of this research study is to test the safety of losartan potassium and see what effects (good and bad) it has on you and your eosinophilic esophagitis.
- Trial name
- NCT01808196
- Testing
- Losartan Potassium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Oxidative Stress
The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients
The clinical and biochemical improvement observed in kidney transplant (RT) recipients is remarkable. The correct functioning of the allograft depends on various factors such as the donor's age, the alloimmune response, the…
- Trial name
- NCT05232370
- Testing
- Angiotensin converting enzyme inhibitor, Angiotensin Receptor Blockers
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales