Clinical trials: Melatonin
Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp
Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.
To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: Intensity of postoperative pain. Bacterial load reduction. Periapical (MMP-9) level.
- Trial name
- RCT (NCT07495605)
- Testing
- 1% melatonin gel, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 50 people
- Sponsor
- Cairo University
Depression, Brain Injuries, Traumatic
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination.
- Trial name
- NCT04400266
- Testing
- Buspirone, Mealatonin
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Healthy, Teenager
Effects of Afternoon and Evening Light on Teenagers' Melatonin Levels, Alertness, Sleepiness and Sleep
Many teenagers are familiar with this: on school days, they have to get up early; during the day, they hardly get any light exposure; in the evening, they go to bed late - and are then tired at school the next day! Around the…
- Conditions
- Healthy, Teenager, Healthy Lifestyle
- Trial name
- TeenLight (NCT05483296)
- Testing
- Dim light condition, Moderate light condition, Bright light condition
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Psychiatric Clinics Basel
Obesity
Effect of Melatonin on Oxidative Stress in Obese Adults (MELASTRESSOB)
The present research project aims to evaluate oxidative stress in a cohort of obese adults, subjected to an in-hospital 3-week multidisciplinary body weight reduction program (BWRP) with or without melatonin.
- Trial name
- MELASTRESSOB (NCT05759429)
- Testing
- BWRP, BWRP + melatonin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Retrognathism, Prognathism
Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy
The bilateral sagittal split osteotomy (BSSO) of the mandible is one of the most used surgical techniques to achieve a harmonious jaw relation in the context of orthognathic surgery.
- Conditions
- Retrognathism, Prognathism, Orthognathic Surgery, Neurosensory Disorder
- Trial name
- NCT05536596
- Testing
- Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Preterm Neonate Analgesia
Melatonin As an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, antioxidant and anti-inflammatory effects, accumulating…
- Trial name
- NCT05971485
- Testing
- Melatonin 10 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Melatonin Production
Melatonin Production Delay in Preterm Infants
Objective: Melatonin production is known to be delayed in preterm-born infants up to 6 months of age. This might be related to exposure of preterm infants to continuous lighting in the NICU during a critical period of pineal…
- Trial name
- NCT00775723
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Tel Aviv University
Glucose, Circadian Rhythm
Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT02642640
- Testing
- melatonin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
CSWS, Developmental and/or Epileptic Encephalopathies
Melatonin for the Treatment of DEE-SWAS
The goal of this study is to learn if melatonin, a naturally produced substance, can help to treat some of the symptoms of DEE-SWAS, a type of epilepsy that causes children to lose skills and development.
- Conditions
- CSWS, Developmental and/or Epileptic Encephalopathies, Electrical Status Epilepticus in Sleep
- Trial name
- NCT07221968
- Testing
- Melatonin
- Volunteers
- 3 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Pregnancy Preterm
Melatonin Levels in Preterm and Term Newborn Infants
The general goal of the present study is to examine the developmental changes caused by melatonin in preterm and term newborns. The major brain lesions associated with cerebral palsy and cognitive impairment in preterm infants…
- Trial name
- MELIP (NCT01340417)
- Testing
- Measurements of melatonin levels in urine, blood, milk.
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Difficulty in Sleep Initiation
A Clinical Study to Assess the Safety and Effectiveness of Herbal Supplement in Adult Human Subjects.
A proof of science/concept clinical study with single-arm, single-blind, to evaluate safety, efficacy and in-use tolerability study of Herbal Supplement in adult human subjects having difficulty in falling asleep.
- Trial name
- NCT05853757
- Testing
- Zzowin Nutra Tablet
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver
Postoperative Pain After Endodontic Treatment
Evaluation of the Effect of Salivary Melatonin Levels on Postoperative Pain and Sleep Quality Following Endodontic Treatments Performed at Different Days and Times
This clinical study aims to evaluate the effect of salivary melatonin levels on postoperative pain and sleep quality in patients undergoing root canal treatment at different times of the day.
- Trial name
- NCT07173699
- Testing
- root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ataturk University
Major Depressive Disorder (MDD) With Insomnia
Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia
Major Depressive Disorder (MDD) affects 5% of the global population and is the second leading cause of disability worldwide. Despite the widespread use of antidepressants, 50-60% of patients do not respond adequately after 8…
- Trial name
- CombiChronoS (NCT07120880)
- Testing
- AD + SHR + active LT and extended-release melatonin 2mg
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Impacted Mandibular Third Molar
The Effect of Topical Application of Hyaluronic Acid and Melatonin Mixture Following Surgical Extraction of Impacted Mandibular Third Molars .
This randomized controlled clinical trial aims to evaluate the clinical and radiographical effects of the application of a mixture of hyaluronic acid and melatonin after surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07735806
- Testing
- Hyaluronic acid and Melatonin mixture, Gel foam
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Dyssomnias
A Multicomponent Intervention for Prevention and Treatment of Sleep Disturbances in a Psychiatric Intensive Care Unit
Hospitalized adult patients suffer from sleep deprivation, which has been associated with multiple negative consequences, both in short and in the long term.
- Trial name
- SUEÑA-SM (NCT04995263)
- Testing
- Sueña component 1: Sleep Hygiene Promotion, Sueña component 2: Periodic Anxiety and Pain Screening, Sueña component 3: Hypnotics and Caffeine Regulation
- Where
- Chile
- Volunteers
- 120 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Pre-menopausal Irregular Cycles and Bleedings
Myo-inositol and Melatonin in Pre-menopausal Women
The purpose of this study is to determine whether myo-inositol and melatonin, or myo-inositol alone, or melatonin alone, are effective in normalizing irregular bleeding and anovulatory cycles in pre-menopausal women.
- Trial name
- NCT01115127
- Testing
- melatonin, myo-inositol, melatonin plus myo-inositol
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Messina