Clinical trials: Melatonin, completed
Diabetes Mellitus, Periodontitis
Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis
Background and aim: Hyperinflammatory host response associated with diabetes mellitus significantly provokes periodontal tissue destruction.
- Conditions
- Diabetes Mellitus, Periodontitis, Melatonin, Matrix Metalloproteinases
- Trial name
- NCT05870358
- Testing
- Melatonin 3 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Yağmur Saraç Gül
Chronic Periodontitis
New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin
The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the…
- Trial name
- HAMELDENT (NCT03656484)
- Testing
- Tetracycline-Metronidazole (TM) group, TM-Melatonin-Hyaluronic acid (TM-MHa) group
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- Concordia Dent Srl
Insomnia
Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women
This study has been designed to compare the effects of melatonin with those of drugs (temazepam and zolpidem) regularly prescribed for the treatment of insomnia, in healthy, middle-aged volunteers.
- Trial name
- NCT00940550
- Testing
- Prolonged-release melatonin, Temazepam, Zolpidem
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Sleep Quality, Sleep Health
Clinical Study to Assess a Dietary Supplement on Sleep Health and Quality
The primary objective of this study is to evaluate the effects of a proprietary oral supplement on the sleep health and quality of people with sleep problems. It is a double-blinded placebo-controlled crossover clinical study.
- Trial name
- NCT05368909
- Testing
- Sleep Supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- 4Life Research, LLC
Delirium, Anesthesia Emergence, Delirium
The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia
Postoperative delirium is a complication that should not be underestimated. As it elaborates many complications that could be avoided when an accurate assessment of the risk factors and interventional measures are taken…
- Trial name
- NCT05236907
- Testing
- Melatonin, No intervention, Midazolam
- Where
- 2 sites in Iraq
- Volunteers
- 36 people
- Sponsor
- University of Baghdad
Sleep Onset Latency, Sleep Quality
Study of the Efficacy of Dietary Supplementation in Targeting Sleep Quality (NutriSom-01B)
single-center, randomized, cross over, double-blind, placebo controlled intervention study
- Trial name
- NutriSom-01B (NCT07200167)
- Testing
- 21 days of intervention with Active Control (AC), 21 days of intervention with Test Product (TP)
- Where
- Slovenia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Sleep Initiation and Maintenance Disorders
Efficacy and Safety of KI1001 in ≥ 55 Years Old Insomnia Patients
KI1001(Circadin®, Prolonged release tablet which contains melatonin) has showed its efficacy to improve sleep quality in over 55 years old primary insomnia patients.
- Trial name
- NCT01450228
- Testing
- KI1001
- Where
- 10 sites in South Korea
- Volunteers
- 170 people
- Sponsor
- Kuhnil Pharmaceutical Co., Ltd.
Genital Herpes
Melatonin Effects on Genital Herpes in Brazilian Women
Genital herpes is a common and increasingly-common infection worldwide. The annual incidence in the United States is 1.75 per 1000 inhabitants. The etiologic agent is the herpes type 1 and 2 strains simplex virus.
- Trial name
- NCT03831165
- Testing
- Melatonin 3 mg, Acyclovir
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Postoperative Pain, Oxidative Stress Response
Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery
Background. Long-term consequences of postoperative pain are detrimental in children. We tested the hypothesis that melatonin reduces postoperative pain and oxidative stress involving sirtuin pathway in children undergoing…
- Trial name
- NCT06724432
- Testing
- oral melatonin
- Where
- 2 sites in Italy
- Volunteers
- 44 people
- Sponsor
- University of Parma
Recovery From Bariatric Surgery
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery
Melatonin has sedative, hypnotic and analgesic properties that make it a good premedication agent before anesthesia and surgery.
- Trial name
- NCT02424071
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Sleep Disturbance
Feasibility Study of Personalized Trials to Improve Sleep Quality
The purpose of this pilot study is to assess the feasibility of using N-of-1 methods in a virtual research study of melatonin intervention for poor sleep quality.
- Trial name
- NCT05349188
- Testing
- Melatonin 3 mg, Melatonin 0.5 mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
ICU Delirium
Circadian Melatonin Rhythms in Critically Ill Patients With Delirium
Delirious patients often suffer from sleep disturbances such as insomnia, sleep fragmentation, daytime somnolence, and reversal of sleep-wake rhythms.
- Trial name
- NCT04721613
- Testing
- Assessment of Melatonin level
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Complications, Fatigue
Melatonin Treatment After Laparoscopic Cholecystectomy
Circadian disturbances occur after surgery. A double blinded, placebo controlled randomized clinical trial was made to investigate effects of melatonin on postoperative fatigue, sleep disturbances and general wellbeing.
- Conditions
- Postoperative Complications, Fatigue, Dyssomnias
- Trial name
- NCT00113906
- Testing
- melatonin
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Sleep, Alertness, Fatigue, Mood, and Performance
Circadian-informed Optimal Bedtime
The goal of this interventional study is to test whether circadian-informed bedtime recommendations can improve sleep, next-day psychomotor vigilance, and subjective well-being among healthy adults.
- Conditions
- Sleep, Alertness, Fatigue, Mood, and Performance, Well-being
- Trial name
- LS4 (NCT07889466)
- Testing
- Optimal Bedtime
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Sleep Quality, Sleep Disorders
Plant Protein With Ashwagandha-Rhodiola for Sleep Quality
This study evaluates whether a combination of plant protein with adaptogenic herbs (ashwagandha and rhodiola) can improve sleep quality in middle-aged adults with sleep disturbances.
- Conditions
- Sleep Quality, Sleep Disorders, Insomnia
- Trial name
- TECOS (NCT07461402)
- Testing
- Plant Protein Supplement, Rhodiola rosea Extract, Ashwagandha KSM-66
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Pablo de Olavide
Primary Insomnia
Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients
This is a phase II study. It is conducted using a randomized, double-blind, 3-arm placebo controlled, parallel group design. Eligible patients will be randomized in a 1:1:1 ratio to receive Neu-P11 20 mg, Neu-P11 50 mg or placebo…
- Trial name
- NCT01489969
- Testing
- Neu-P11
- Where
- 9 sites in United States
- Volunteers
- 137 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep
Somato® (Phytomelatonin) Versus Synthetic Melatonin and Placebo on Sleep Quality
This study examines the effects of a plant-based phytomelatonin supplement compared to synthetic melatonin and placebo in adults with suboptimal sleep quality.
- Trial name
- NCT07669766
- Testing
- Plant-based melatonin, Melatonin
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Premedication, Anaesthesia
Melatonin Premedication in Children Undergoing Surgery
Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of…
- Trial name
- NCT02265822
- Testing
- melatonin in children premedication, midazolam in children premedication
- Volunteers
- 92 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Attention Deficit Hyperactivity Disorder
Sleep and Nocturnal Melatonin in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
This study will investigate the effects of methylphenidate on sleep in adults with Attention Deficit/ Hyperactivity Disorder (ADHD) using polysomnographic parameters.
- Trial name
- ADHD (NCT01329510)
- Testing
- One-night polysomnographic recordings
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Assaf-Harofeh Medical Center