Clinical trials: Metformin, completed
Insulin Resistance, Prediabetes
Metformin and Longevity Genes in Prediabetes
Pre-diabetes, a condition characterized by hyperglycaemia, is associated with increased cardiovascular risk and reduced life expectancy, as compared to the general population.
- Conditions
- Insulin Resistance, Prediabetes, Aging, Inflammation
- Trial name
- NCT01765946
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Padova
Diabetes Mellitus
Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment
The purposes of the study is to determine whether blood sugar control is different between Lantus and a third oral anti-diabetic agent when added to patients who fail a thiazolidinedione and sulfonylurea or metformin combination.
- Trial name
- NCT00046462
- Testing
- Lantus (insulin glargine [rDNA origin] injection), Metformin, Glyburide
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Sanofi
Healthy
A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
The purpose of this study is to assess the bioequivalence (similarity of the drug amount in blood among the formulations) of the fixed dose combination (two components combined in one tablet) of canagliflozin and metformin…
- Trial name
- NCT02077803
- Testing
- Canagliflozin, 100 mg, Metformin XR, 500 mg, CANA/MET XR FDC, Formulation 1, 50 mg/1000 mg
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Type 1 Diabetes
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-<20 years, with type 1…
- Trial name
- NCT01881828
- Testing
- Metformin (glucophage)
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Jaeb Center for Health Research
Drug Mechanism, Drug Usage
Does Vildagliptin Affect Portal Vein Pressure In Patients With Type 2 Diabetes Mellitus? A Cross Sectional Study
This study investigated how vildagliptin (a di-peptidyl peptidase 4 inhibitor) affects portal vein pressure and hepatosteatosis in patients with type 2 diabetes mellitus.
- Trial name
- NCT01963130
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Bezmialem Vakif University
Healthy Volunteers
A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
The primary purpose of the study is to evaluate the effect of itraconazole, a strong cytochrome P450 (CYP) 3A4 inhibitor, on the pharmacokinetics (PK) of emraclidine and metabolite CV-0000364 in Part A, the effect of…
- Trial name
- NCT05965219
- Testing
- Emraclidine, Itraconazole, Carbamazepine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Diabetes Type 2
Phase II Safety and Efficacy Study of Oral ORMD-0801 in Patients With Type 2 Diabetes Mellitus
Randomized, double-blind, placebo-controlled, parallel group study.
- Trial name
- NCT02496000
- Testing
- ORMD-0801
- Where
- 34 sites in United States
- Volunteers
- 188 people
- Sponsor
- Oramed, Ltd.
Type 2 Diabetes Mellitus
Galvus on Met Phase 4 Study : Study to Evaluate the Efficacy and Safety of Early Combination of Vildagliptin and Metformin in Patients With Type 2 Diabetes Mellitus
The study design of this trial is open-label, randomized, multi-center, parallel-group study.
- Trial name
- NCT00975065
- Testing
- vildagliptin 50 mg bid plus metformin 1500mg (Galvus+Diabex), metformin 1500mg plus metformin 500mg or 1000mg (Diabex)
- Where
- South Korea
- Volunteers
- 266 people
- Sponsor
- Handok Inc.
Hyperinsulinism, Polycystic Ovary Syndrome
Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome
OBJECTIVES: I. Determine whether reduction of serum insulin levels by metformin increases ovulatory response to clomiphene or spontaneous ovulation in obese women with polycystic ovary syndrome.
- Trial name
- NCT00005654
- Testing
- clomiphene citrate, metformin
- Volunteers
- 88 people
- Sponsor
- National Center for Research Resources (NCRR)
Healthy
Drug-Drug Interaction Study With Metformin and Nizatidine
This study will address the following question: Does nizatidine affect the pharmacokinetics of metformin in healthy volunteers? Recent studies in the Giacomini laboratory have indicated that nizatidine may block metformin…
- Trial name
- NCT01409395
- Testing
- Metformin and nizatidine, Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PreDiabetes
Preventing Diabetes
The purpose of this project is to improve the quality of weight management care for patients with pre-diabetes and overweight or obesity.
- Trial name
- PD (NCT05395377)
- Testing
- Registered Dietitian/Nutritionist, Diabetes Prevention Program, Weight Watchers, Reimagined
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Geisinger Clinic
Type 2 Diabetes Mellitus
Safety, Tolerance and Activity of HE3286 in Patients With Type 2 Diabetes Mellitus
This is a phase II, double-blind, randomized, placebo-controlled study of the safety, tolerance and activity of HE3286 in patients with type 2 diabetes mellitus.
- Trial name
- NCT00694057
- Testing
- HE3286
- Where
- 22 sites in United States
- Volunteers
- 164 people
- Sponsor
- Harbor Therapeutics
Diabetes, Diabetes Mellitus, Type 2
Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.
This trial is conducted in the United States of America (USA). The study will compare A1C reduction achieved in patients receiving biphasic insulin aspart 70/30 once or twice daily to patients receiving exenatide twice daily.
- Trial name
- NCT00313001
- Testing
- biphasic insulin aspart, exenatide
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- Novo Nordisk A/S
Obesity
Metformin and Core Temperature in Obese and Lean Males
Metformin is known to increase 18F-FDG uptake in subjects using metformin in retrospective trials. In this study the researchers aim to investigate the influence of metformin (500 mg 1/day) on temperature in the colon, glucose…
- Trial name
- McTOM (NCT02783053)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy
Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy Participants
This study investigated the bioequivalence and drug-drug interaction of Metformin/Gliclazide fixed combination tablet compared to co-administration of individual tablets of Metformin and Gliclazide.
- Trial name
- NCT03467945
- Testing
- Metformin/Gliclazide Fixed Combination, Metformin, Gliclazide
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Type 2 Diabetes
Effect of GLP-1 on Angiogenesis
GLP-1 receptor agonists are introduced in the treatment of type 2 Diabetes (T2D) and their efficacy is documented. However, safety aspects are also important to evaluate with respect to micro and macrovascular complications…
- Trial name
- ANGIOSAFE 1 (NCT02686177)
- Testing
- Liraglutide, Metformin or sulfonylurea
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polycystic Ovary Syndrome
SGLT2 Inhibitors in Patients With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with a prevalence of 5% to 15% in premenopausal women. Patients with PCOS presents as abnormal menstruation, ovulation disorders and/or hyperandrogenemia, and often…
- Trial name
- PCOS (NCT04700839)
- Testing
- SGLT2 inhibitors, Metformin
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai 10th People's Hospital
Type 2 Diabetes Mellitus
Bioequivalence Study of Saxagliptin and Glucophage Combination Formulations in Healthy Subjects (A)
To demonstrate bioequivalence of a 2.5 mg saxagliptin/500 mg metformin (glucophage) immediate release (IR) fixed dose combination (FDC) tablet to the 2.5 mg saxagliptin tablet and 500 mg metformin IR tablet co-administered to…
- Trial name
- NCT00899470
- Testing
- Co-administration of Saxagliptin and Metformin IR, Fasted, Saxagliptin/Metformin, Fasting, Co-administration of Saxagliptin and Metformin IR, Fed
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus
Diabetes Treatment With Glucobay in Combination With Metformin
In this prospective, non interventional, observational Post Marketing Survelliance study data are obtained on the efficacy, safety and tolerability of Glucobay treatment on top of metformin under daily life treatment…
- Trial name
- NCT01612741
- Testing
- Acarbose (Precose/Glucobay, BAYG5421)
- Where
- India
- Volunteers
- 19,509 people
- Sponsor
- Bayer
Diabetes Mellitus, Type 2
A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes
This study will compare the effect of semaglutide once weekly to insulin aspart 3 times daily as add on to metformin and insulin glargine in people with type 2 diabetes.
- Trial name
- SUSTAIN 11 (NCT03689374)
- Testing
- Semaglutide, Insulin aspart, Insulin glargine U100
- Where
- 210 sites in Bosnia and Herzegovina, Bulgaria and 19 more
- Volunteers
- 2,274 people
- Sponsor
- Novo Nordisk A/S
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