Clinical trials: Metformin, completed
Type 2 Diabetes Mellitus, Inadequate Glycaemic Control
A Multi-Center, Randomized, Double-Blind, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin Co-administered With Dapagliflozin Compared to Saxagliptin or Dapagliflozin All Given as add-on Therapy to Metformin in Subject With Type 2 Diabetes
The aim of this study is to evaluate safety and efficacy of therapy with saxagliptin 5mg co-administered with dapagliflozin 5mg, compared to therapy with saxagliptin 5mg or dapagliflozin 5mg in patients who are inadequately…
- Trial name
- NCT02681094
- Testing
- Dapagliflozin, Saxagliptin
- Where
- 110 sites in United States, Canada and 4 more
- Volunteers
- 905 people
- Sponsor
- AstraZeneca
Metastatic Colorectal Cancer
Metformin and 5-fluorouracil for Refractory Colorectal Cancer.
This is a phase II trial to evaluate efficacy and safety of Metformin and Fluorouracil in patients with metastatic colorectal cancer (CRC) who have progressed after Oxaliplatin and Irinotecan based chemotherapy.
- Trial name
- NCT01941953
- Testing
- Metformin and Fluorouracil
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Breast Cancer Female
Role of Adding Metformin to Neoadjuvant Chemotherapy in Patients With Breast Cancer (METNEO)
Metformin, the widely prescribed oral hypoglycemic drug, is well known for its established efficacy, favorable safety profile, and low cost.
- Trial name
- METNEO (NCT04170465)
- Testing
- Metformin Hydrochloride 850 mg Tablets, AC-T chemotherapy regimen
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Damanhour University
Healthy
Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Male and Female
The purpose of this trial is to investigate bioequivalence of a newly developed fixed dose combination (FDC) tablet containing empagliflozin and metformin extended release compared to the free combination of empagliflozin and…
- Trial name
- NCT02266472
- Testing
- metformin, empagliflozin/metformin, empagliflozin
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes Mellitus
A 12-week Study To Evaluate PF-06291874 Once a Day in Adults With T2DM Inadequately Controlled On Metformin
The purpose of this study is to determine whether PF-06291874 is effective in the treatment T2DM
- Trial name
- NCT02554877
- Testing
- PF-06291874
- Where
- 38 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Pfizer
Diabetes Mellitus
Dulaglutide in Diabetic Patients, Relationship Between Arterial Stiffness, Endothelial Function, Clinical and Laboratory Variables
The study aims to evaluate arterial stiffness and endothelial function indexes and their relationship with clinic and laboratory varible in a group of diabetic patients in treatment with dulaglutide
- Trial name
- NCT03824002
- Testing
- Dulaglutide, Aspart insulin, Glargine
- Where
- Italy
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Palermo
PreDiabetes, Aging
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
The goal of this pilot and feasibility study is to investigate the effects of a short course of metformin therapy on a surrogate marker of cellular senescence and autophagy among adult patients with prediabetes.
- Trial name
- NCT03309007
- Testing
- Metformin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Diabetes Mellitus Type 2, Metformin
Variation in Serum Levels of Metformin in Patients With Reduced Renal Function
Metformin is widely used for treatment of type 2 diabetes mellitus. Side-effects are few and mainly from the gastrointestinal tract.
- Conditions
- Diabetes Mellitus Type 2, Metformin, Pharmacokinetics
- Trial name
- NCT00767351
- Volunteers
- 30 people
- Sponsor
- Skane University Hospital
Type 2 Diabetes Mellitus
Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin in Patients With Type 2 Diabetes
The study will demonstrate the effect of 24 weeks of treatment with vildagliptin compared to placebo on insulin sensitivity in patients with type 2 diabetes mellitus (T2DM) treated with metformin, assessed as glucose Rd (rate of…
- Trial name
- NCT01356381
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood
For Part 1 of the trial, the main objective is to assess the effect of a single dose of zongertinib on the pharmacokinetics of a single dose of dabigatran-etexilate.
- Trial name
- NCT06504862
- Testing
- Zongertinib, Dabigatran-etexilate, Rosuvastatin
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus
Phase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo
Study D5553C0003 is a 28-week, randomized, double-blind, active-controlled, multicenter, Phase 3 efficacy and safety study with 24-week and 52-week extension phases of simultaneous administration of exenatide once weekly (EQW) 2…
- Trial name
- NCT02229396
- Testing
- Exantide with Dapagliflozin, Exentide, Dapagliflozin
- Where
- 133 sites in United States, Hungary and 4 more
- Volunteers
- 695 people
- Sponsor
- AstraZeneca
Insulin Resistance, Chronic Heart Failure
Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes
The aim of the study is to evaluate the effect of metformin on myocardial function, insulin resistance and selected metabolic markers in patients with type 2 diabetes and heart failure (HF+DM+) in a cross-over, randomized…
- Trial name
- CARMET (NCT01690091)
- Testing
- Metformini hydrochloridum (Siofor 1000 tbl, Berlin)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Type 2 Diabetes Mellitus
Randomized Sitagliptin Withdrawal Study (MK-0431-845)
This is a trial of continuing sitagliptin versus withdrawing sitagliptin in participants with Type 2 diabetes mellitus (T2DM) and inadequate glycemic control who initiate and titrate insulin glargine (LANTUS®) based on a…
- Trial name
- NCT02738879
- Testing
- Sitagliptin, Metformin, Metformin XR
- Volunteers
- 746 people
- Sponsor
- Merck Sharp & Dohme LLC
Gestational Diabetes Mellitus
A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus
Rationale Gestational diabetes mellitus (GDM) complicates 5-7% of pregnancies. Major hazards include macrosomia, polyhydramnios, labor trauma and neonatal hypoglycemia.
- Trial name
- NCT01563120
- Testing
- metformin, glybenclamide
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- HaEmek Medical Center, Israel
Healthy
Pharmacokinetic Interactions Between Atorvastatin and Metformin in Healthy Male Subjects
The purpose of the study is to assess the pharmacokinetic interactions between atorvastatin and metformin single or co-administered in healthy volunteers
- Trial name
- NCT01765023
- Testing
- Period I : atorvastatin, Period II : atorvastatin and metformin, Period I : metformin, Period II : atorvastatin and metformin
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Diabetes Mellitus, Type 2
A Research Study in People With Type 2 Diabetes to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine
This study compares insulin 287 (a possible new medicine) to insulin glargine (a medicine doctors can already prescribe) in people with type 2 diabetes.
- Trial name
- NCT03922750
- Testing
- Insulin icodec, Insulin glargine U100
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 154 people
- Sponsor
- Novo Nordisk A/S
Diabetes
A Study of Saxagliptin in Subjects With Type 2 Diabetes Who Have Inadequate Blood Sugar Control With Sulfonylureas
The purpose of this trial is to understand if adding saxagliptin to a sulfonylurea is safe and works better than increasing the amount of sulfonylurea a patient takes
- Trial name
- NCT00313313
- Testing
- Saxagliptin, Glyburide, Metformin
- Where
- 115 sites in United States, Argentina and 11 more
- Volunteers
- 768 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 2
Effects of Dietary Fiber on Glucose Control in Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to determine the effect of a commercial dietary fiber supplement on patients with type 2 diabetes mellitus, in the way of glucose control, insulin action in the body, and the gut microbiota (bacteria)…
- Trial name
- NCT03552991
- Testing
- Agiocur Pregranules
- Volunteers
- 14 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus, Type 2
Evaluation of Food Effect on the Pharmacokinetics of Sustained Release Metformin in Healthy Indian Volunteers
Metformin hydrochloride in its immediate release (IR) form has been successfully used for decades in the treatment of type 2 diabetes; however the IR formulation may be associated with gastrointestinal side effects (especially…
- Trial name
- NCT01561976
- Testing
- Metformin hydrochloride prolonged release, Metformin hydrochloride sustained release/Glimepiride
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
Effect of Apple Cider Vinegar and Metformin Combination vs Metformin Alone in Type 2 Diabetics
'This study aims to compare the effect of Metformin alone vs Metformin plus Apple Cider Vinegar in newly diagnosed Type 2 Diabetic Patients
- Trial name
- NCT04120259
- Testing
- Metformin Oral Tablet, Vinegar
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Ziauddin University
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