Clinical trials: Methotrexate, completed
Rheumatoid Arthritis
A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate
This was a Phase II, randomized, double-blind, multicenter study designed to evaluate the safety and efficacy of rituximab, administered at two different regimens for 2 years, in patients with moderate to severe active rheumatoid…
- Trial name
- RUMBA (NCT00243412)
- Testing
- folate, methotrexate, methylprednisolone
- Volunteers
- 42 people
- Sponsor
- Genentech, Inc.
Psoriasis
Assessing the Long Term Effectiveness and Safety of Biotherapies in the Treatment of Cutaneous Psoriasis
PSOBIOTEQ is a national multicentric prospective cohort of cutaneous psoriasis patients receiving systemic treatment (biotherapy or DMARDs) for moderate to severe cutaneous psoriasis.
- Trial name
- PSOBIOTEQ (NCT01617018)
- Where
- France
- Volunteers
- 4,613 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis
Safety, Tolerability, Pharmacodynamics and Efficacy Study of TAB08 in Patients With Rheumatoid Arthritis
This study is in two stages: Stage 1 purpose is to assess safety, tolerability, and efficacy of multiple TAB08 doses in patients with active Rheumatoid Arthritis in which methotrexate (MTX) treatment is not enough effective.
- Trial name
- NCT01990157
- Testing
- TAB08
- Where
- 2 sites in Russia
- Volunteers
- 18 people
- Sponsor
- Theramab LLC
Breast Cancer
Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002582
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,000 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Juvenile Idiopathic Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA)
This study will evaluate the efficacy and safety of RoActemra/Actemra (tocilizumab) in patients with active systemic juvenile idiopathic arthritis (sJIA) who have an inadequate clinical response to NSAIDs and corticosteroids.
- Trial name
- NCT00642460
- Testing
- tocilizumab [RoActemra/Actemra], Non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate
- Where
- 54 sites in United States, Argentina and 17 more
- Volunteers
- 112 people
- Sponsor
- Hoffmann-La Roche
Lymphoma, Non-Hodgkin
Blood Stem Cell Transplant With Low Dose Chemotherapy for Relapsed Follicular Non-Hodgkin's Lymphoma (BMT CTN 0701)
Blood stem cell transplants are one treatment option for people with lymphoma or other types of blood cancers. For this type of treatment, family members or unrelated donors with a similar tissue type usually donate their blood…
- Trial name
- NCT00912223
- Testing
- Hematopoietic Stem Cell Transplant
- Where
- 21 sites in United States
- Volunteers
- 65 people
- Sponsor
- Medical College of Wisconsin
Rheumatic Diseases
Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism
The aim of this study is 1) To describe the level and determinants of methotrexate adherence in patients with chronic inflammatory rheumatism (rheumatoid arthritis, spondyloarthritis and psoriatic arthritis) in the department of…
- Trial name
- NCT02926560
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Childhood Cancer, Communication
Pictorial Support in Person-centred Care for Children (PicPecc)
Introduction: Person-centred care is based on the assumption that every person has resources that should be used in the care situation.
- Conditions
- Childhood Cancer, Communication, Symptoms and Signs
- Trial name
- PicPecc (NCT04433650)
- Testing
- Pictorial support in person-centred care for children (PicPecc)
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Göteborg University
Rheumatoid Arthritis
A Study to Investigate the Safety and Efficacy of ABT-122 Given With Methotrexate in Subjects With Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate
This study is a Phase 2 randomized, double-blind, double-dummy, parallel-group study designed to assess the safety, tolerability, efficacy, pharmacokinetics and immunogenicity of multiple doses of ABT 122 in subjects with active…
- Trial name
- NCT02141997
- Testing
- adalimumab, ABT-122
- Volunteers
- 222 people
- Sponsor
- AbbVie
Acute Lymphoblastic Leukemia
A Study of Children With Refractory or Relapsed ALL
The main purpose of this study is to find out which form of asparaginase (the native E. coli/Erwinia) or PEG-asparaginase) is more effective during induction treatment for children with acute lymphoblastic leukemia that has come…
- Trial name
- NCT00187083
- Testing
- Topotecan, dexamethasone, vincristine, E. coli Asparaginase, PEG-L-asparaginase, erwinia asparaginase
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Osteosarcoma
A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX
The purpose of this study is to investigate to which extend osteosarcoma patients do NOT meet the criteria for successfully advancement to next planned chemotherapy course.
- Trial name
- FORTO (NCT02383901)
- Testing
- Methotrexate
- Where
- 5 sites in Hungary, Norway and 2 more
- Volunteers
- 116 people
- Sponsor
- Isofol Medical AB
Healthy, Rheumatoid Arthritis
MAD Study of IA-14069
The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending oral doses of IA-14069 in healthy subjects and in patients with RA on stable dosese of MTX, with…
- Trial name
- NCT05533372
- Testing
- IA-14069, Methotrexate
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ILAb Co., Ltd.
Myelodysplastic Syndrome, Hodgkin's Lymphoma
Chemotherapy and Unrelated Donor Stem Cell Transplantation for Patients With Cancers of the Blood and Immune System
Background: Major problems with stem cell transplantation (SCT) for cancer treatment are a lack of suitable donors for patients without a human leukocyte-antigen (HLA) tissue-matched sibling and graft-versus-host disease (GVHD)…
- Conditions
- Myelodysplastic Syndrome, Hodgkin's Lymphoma, Non-Hodgkin's Disease, Acute Leukemia
- Trial name
- NCT00520130
- Testing
- Rituximab, Cyclosporine, Allogenic stem cell transplant (ASCT)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Cancer Institute (NCI)
Rheumatoid Arthritis
A Study Comparing SB5 to Humira® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy
This is a randomised, double-blind, parallel group, multicentre clinical study to evaluate the efficacy, safety, tolerability, pharmacokinetics and immunogenicity of SB5 compared to Humira® in subjects with moderate to severe RA…
- Trial name
- NCT02167139
- Testing
- Humira (adalimumab), SB5 (proposed biosimilar to adalimumab)
- Where
- 2 sites in Lithuania, Poland
- Volunteers
- 544 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Childhood Acute Lymphoblastic Leukemia in Remission
Study to Assess Compliance With Long-Term Mercaptopurine Treatment in Young Patients With Acute Lymphoblastic Leukemia in Remission
This clinical trial is assessing compliance with long-term mercaptopurine treatment in young patients with acute lymphoblastic leukemia in remission.
- Trial name
- NCT00268528
- Testing
- Compliance Monitoring, Laboratory Biomarker Analysis, Mercaptopurine
- Where
- 135 sites in United States, Australia and 1 more
- Volunteers
- 720 people
- Sponsor
- Children's Oncology Group
Lymphoblastic Leukemia, Acute, Childhood, Myelogenous Leukemia, Acute, Childhood
AC220 for Children With Relapsed/Refractory ALL or AML
This is a phase I study of the investigational drug AC220 combined with cytarabine and etoposide in pediatric patients with relapsed acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML).
- Trial name
- NCT01411267
- Testing
- AC220, Cytarabine, Etoposide
- Where
- 11 sites in United States
- Volunteers
- 24 people
- Sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
Brain and Central Nervous System Tumors
Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002463
- Testing
- MOPP Regimen, Leucovorin Calcium, Mechlorethamine Hydrochloride
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Rheumatoid Arthritis
Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Methotrexate
The primary objective of this study is to evaluate the efficacy (ACR20) of Rob 803 administered orally once daily for 12 weeks in combination with a stable dose of methotrexate in subjects with moderate or severe active RA.
- Trial name
- ROBUST (NCT00525213)
- Testing
- Rob 803
- Where
- 34 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 224 people
- Sponsor
- OxyPharma
Rheumatoid Arthritis
A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate
This study will evaluate immune response following administration of zoster vaccine in subjects with rheumatoid arthritis who are receiving background methotrexate and initiate 5 mg twice daily of tofacitinib or placebo for…
- Trial name
- NCT02147587
- Testing
- Tofacitinib
- Where
- 36 sites in United States
- Volunteers
- 112 people
- Sponsor
- Pfizer
Methotrexate Adverse Reaction, Oral Mucositis
Stratification of Oral Ulcers in Rheumatoid Arthritis Patients Kept on Methotrexate
This study included rheumatoid arthritis patients receiving Methotrexate as monotherapy. All eligible patients were subjected to thorough clinical examination and full history to identify oral events.
- Trial name
- NCT04540250
- Testing
- questionnaire
- Volunteers
- 804 people
- Sponsor
- Beni-Suef University