Clinical trials: Metronidazole
Colorectal Surgery
Mechanical Bowel Prep Randomized Study
Following colon surgery, surgical site infection (SSI) is the most common complication and leads to longer recovery time for patients and increased health care costs.
- Trial name
- NCT04931173
- Testing
- IVA+OA versus IVA+MBP+OA
- Volunteers
- 1,062 people
- Sponsor
- Mount Sinai Hospital, Canada
Colorectal Neoplasms, Diverticulitis
Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery.
- Conditions
- Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection
- Trial name
- NCT03042091
- Testing
- Polyethylene Glycol, Neomycin, Metronidazole Hydrochloride
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Thomas Jefferson University
Pregnancy Complications, Diabetes Mellitus
Correlation of CGM Metrics With OGTT and Pregnancy Outcomes in Pregnant Women With or Without a High Risk for GDM
the aim of the study is to obtain CGM data concomitant with OGTT and to determine what CGM metrics obtained in pregnant women with and without a high risk of GDM correlate best with the diagnostic OGTT (obtained via the 2-step…
- Conditions
- Pregnancy Complications, Diabetes Mellitus, Hyperglycemic Disorder
- Trial name
- NCT05537480
- Testing
- Continuous glucose monitoring device
- Where
- Israel
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Migraine
Erenumab - Comprehensive Assessment of Efficacy in (High-Frequency) Episodic Migraine
The primary objective of this study is to evaluate the treatment benefit of erenumab on headache duration of at least moderate pain intensity.
- Trial name
- EMBRACE (NCT04252742)
- Testing
- Erenumab
- Where
- 91 sites in United States, Bulgaria and 7 more
- Volunteers
- 512 people
- Sponsor
- Amgen
H Pylori Infection
Prevalence of Asymptomatic H Pylori Infection Among Patients Undergoing PCI and Impact of Its Eradication on Occurrence of GIT Symptoms and Bleeding"
In the present study, the aim was to report the prevalence of positive H. pylori infection in an unselected population referred for coronary intervention and likely to required DAPT or DPI, also the study assessed impact of H.
- Trial name
- NCT07487142
- Testing
- BISMUTH TETRACYCLINE METRONIDAZOLE OMEPRAZOLE
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Beni-Suef University
Prostate Cancer (Adenocarcinoma), Metastatic Prostate Cancer
Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer
To determine if dexamethasone or dexamethasone plus metronidazole restore sensitivity to abiraterone for the treatment of metastatic prostate cancer.
- Trial name
- NCT06616597
- Testing
- Abiraterone acetate, Dexamethasone, Metronidazole
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Helicobacter Pylori Infection
Comparison of Therapy in Treatment of Patients With Helicobacter Pylori Infection: Concomitant Versus Hybrid Therapy.
The aim of the study is to compare the effectiveness of two therapeutic protocols in the treatment of Helicobacter pylori infection.
- Trial name
- NCT03572777
- Testing
- Concomitant therapy, Hybrid therapy
- Where
- Croatia
- Volunteers
- 159 people
- Sponsor
- Antonio Mestrovic
Melanoma (Skin), Liquid Biopsy
Biobanking and New Biomolecular Metrics
The goal of this Interventional study aims to apply, in our Institutes, a 4p oncological model i.e. predictive, personalized, of precision and participated (Regina Elena and San Gallicano).
- Trial name
- Melamoma4p (NCT05906277)
- Testing
- Biopsy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Regina Elena Cancer Institute
Helicobacter Pylori Infection
Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection
The prevalence of H. pylori antibiotic resistance has reached an alarming level worldwide. Antibiotic stewardship programs should be urgently developed and implemented. However, H.
- Trial name
- NCT05332444
- Testing
- susceptibility-guided tailored therapy (Group A), guidelines-recommended empiric therapy (Group B)
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Post-cardiac Surgery
Elliptical Training Versus Ergo-meter on Cardiopulmonary Parameters in Post CABG Patients
To determine the effects of elliptical training versus ergo-meter on cardiopulmonary parameters in post CABG patients
- Trial name
- NCT04615481
- Testing
- Elliptical Training Group, Ergo-metric Training Group
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Riphah International University
Type 1 Diabetes Mellitus With Hypoglycemia
DailyDose Smart Snack Study for T1D on MDI
This is a single-center, open-label, crossover trial with two arms and two periods (2x2) and one-week washout period. The study is designed to evaluate the efficacy of an AI-based bedtime smart snack intervention in reducing…
- Trial name
- NCT05967260
- Testing
- DailyDose Smart Snack app, Dexcom G6 CGM
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Pregnancy
The Association Between the Transfer of Lactobacilli From the Gastrointestinal Tract to the Vagina and the Prevention / Eradication of Abnormal Vaginal Flora in High Risk Pregnancies
Pregnant women at high risk for preterm labor from at least 13 weeks of gestation will be tested to detect abnormal vaginal flora (AVF) or its severe form - bacterial vaginosis (BV) by taking vaginal smear.
- Trial name
- NCT02430246
- Testing
- Urex Plus, Probotic capsule containing L. rhamnosus GR-1and L. reuteri RC-14
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- HaEmek Medical Center, Israel
Gastritis H Pylori
14-day Quadruple Therapy Versus Triple Therapy in HP Eradication
In this prospective randomized-controlled study, treatment-naive H. pylori-infected patients are randomized to receive either standard triple therapy or sequential therapy.
- Trial name
- HEPRA (NCT04769583)
- Testing
- metronidazole based quadriple therapy
- Where
- Tunisia
- Volunteers
- 121 people
- Sponsor
- mohamed bouchoucha
Perianal Fistula, Crohn Disease
Fistulodesis Pilot Study for Closure of Perianal Fistulae
In this pilot study a new surgical treatment approach for perianal fistulae, called Fistulodesis, is performed. The study aims to assess effectiveness, safety and tolerability of the Fistulodesis procedure.
- Trial name
- NCT03322488
- Testing
- Fistulodesis
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Helicobacter Pylori Infection
Sequential and Hybrid Therapies for H Pylori Infection
Primary: To evaluate efficacy of 14 day 2-phase sequential therapy given in two forms. One in which the first component consists of a proton pump inhibitor and amoxicillin given for 7 days followed by the PPI, clarithromycin and…
- Trial name
- NCT01085786
- Testing
- 14-day sequential treatment, 14-day hybrid treatment
- Where
- 2 sites in Taiwan
- Volunteers
- 240 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Nosocomial Infection, Pneumonia
Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
Infection developing in the intensive care unit is a common complication of critical illness, but notoriously difficult to diagnose.
- Conditions
- Nosocomial Infection, Pneumonia, Systemic Inflammatory Response Syndrome, Critical Illness
- Trial name
- NCT00438269
- Testing
- Site-specific empiric regimens included: Meropenem, Piperacillin/tazobactam, Ciprofloxacin and cefazolin +/- metronidazole
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Critical Care Trials Group
Paediatric Asthma
Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma
This study is to evaluate the efficacy of the digital health assistant (DHA) "Alex" in improving asthma control in asthmatic children and adolescents aged 10 to 19 compared to their baseline values.
- Trial name
- ALEX (NCT07472283)
- Testing
- Phase I (months 1-3): DHA core functionality, Phase II (months 3-6): platform augmentation, Embedded qualitative study
- Where
- 5 sites in Romania
- Volunteers
- 42 people
- Sponsor
- University Children's Hospital Basel
Ambulatory Care, Emergency Services, Hospital
The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments
INTRODUCTION Whereas low-acuity ambulatory patients have been cited as a source of emergency department (ED) overuse or misuse, it is argued that patient evaluation in the ED may end up being more cost-effective.
- Conditions
- Ambulatory Care, Emergency Services, Hospital, Quality of Care, Costs
- Trial name
- NCT05892666
- Testing
- On-site recruitment (information and consent) following a random sampling recruitment schedule, First phone call 1-3 days after the initial visit, Second phone call 8-14 days after the initial visit
- Where
- 7 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Simon Berthelot
Appendicular Mass, Acute Appendicitis
Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass
This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.
- Conditions
- Appendicular Mass, Acute Appendicitis, Appendiceal Phlegmon, Appendicitis With Periappendicular Abscess
- Trial name
- NCT07837531
- Testing
- Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Complicated Appendicitis
Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.
The PIPA trial is a prospective, multicentre, cluster randomized cluster crossover non-inferiority study. We aim to test whether a three-day postoperative course of per oral antibiotics is non-inferior to a three-day…
- Trial name
- PIPA (NCT04803422)
- Testing
- Antibiotic
- Where
- 2 sites in Denmark
- Volunteers
- 3,193 people
- Sponsor
- Zealand University Hospital
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