Clinical trials: Metronidazole
Adenoma Detection Rate, Colonoscopy
Can Overall Adenoma Detection Rate Replace Screening Adenoma Detection Rate ? Multicenter Study
This is a prospective equivalence colonoscopy study evaluating whether overall adenoma detection rate (ADR) is a reliable alternate for screening ADR.
- Trial name
- NCT05125939
- Testing
- Comparison of ADR
- Where
- 6 sites in United States, Taiwan
- Volunteers
- 2,707 people
- Sponsor
- Evergreen General Hospital, Taiwan
Healthy Controls, Parkinson's Disease
Development of Digital Services for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06733077
- Testing
- gait with cueing wearable device and neuro-ocular performance
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Recurrent Prostate Carcinoma, Stage I Prostate Cancer
A Phase II Study of PROSTVAC-V (Vaccinia)/TRICOM and PROSTVAC-F (Fowlpox)/TRICOM With GM-CSF in Patients With PSA Progression After Local Therapy for Prostate Cancer
Vaccines made from a gene-modified virus may help the body build an effective immune response to kill tumor cells. Biological therapies, such as GM-CSF, may stimulate the immune system in different ways and stop tumor cells from…
- Conditions
- Recurrent Prostate Carcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- NCT00108732
- Testing
- Bicalutamide, Goserelin Acetate, Recombinant Fowlpox-PSA(L155)/TRICOM Vaccine
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Recurrent Soft Tissue Sarcoma, Resectable Soft Tissue Sarcoma
An Imaging Agent (Fluorodopa F 18) With Positron Emission Tomography/Magnetic Resonance Imaging for Assessing Treatment Response in Patients With High-Grade Soft Tissue Sarcomas
This study evaluates the use of a new imaging agent called fluorodopa F 18 (18F-DOPA) with positron emission tomography/magnetic resonance imaging (PET/MRI) for assessing treatment response in patients undergoing standard of care…
- Conditions
- Recurrent Soft Tissue Sarcoma, Resectable Soft Tissue Sarcoma, Soft Tissue Sarcoma
- Trial name
- NCT05560009
- Testing
- Fluorodopa F 18, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Hip Osteoarthritis
Prospective Clinical Follow-up of the Echo Bi-Metric Microplasty Stem for Total Hip Arthroplasty
The primary objective of this study is to characterize survivorship of the Echo Bi-Metric Microplasty stem in unilateral or bilateral primary total hip arthroplasty at 5 years postoperative.
- Trial name
- NCT04326010
- Testing
- Surgery
- Where
- 6 sites in United States
- Volunteers
- 206 people
- Sponsor
- Zimmer Biomet
Prevention of Postpartum Sepsis
Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection
Randomised controlled trial to investigate the efficacy of adding metronidazole pre-operatively to kefazolin in reducing postpartum infection
- Trial name
- NCT04792710
- Testing
- Metronidazole
- Where
- South Africa
- Volunteers
- 1,000 people
- Sponsor
- University of Pretoria
Helicobacter Pylori Infection
Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait
Eradication of H. pylori reduces morbidity in patients with chronic gastritis and can prevent gastric cancer. We aimed to evaluate the efficacy of clarithromycin-based triple therapy and non-bismuth based quadruple therapy for…
- Trial name
- NCT04617613
- Testing
- Omeprazole, Amoxicillin, Metronidazole and Clarithromycin, Omeprazole, Amoxicillin and Clarithromycin
- Volunteers
- 603 people
- Sponsor
- Al-Azhar University
Intubation, Laryngoscopy
Enhancing Difficult Laryngoscopy Prediction Through A Mixed Scoring System
This study aims to develop a comprehensive airway assessment score including traditional bedside clinical tests and ultrasound measurements with high accuracy in predicting difficult airway, and to validate it through testing it…
- Conditions
- Intubation, Laryngoscopy, Anesthesia
- Trial name
- NCT06815952
- Where
- Lebanon
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Regenerative Endodontics
Regenerative Endodontics Using Different Intracanal Medicaments on Radiographic Outcomes and Periapical MMP-8 Levels
Two-session regenerative endodontic treatment was applied to 20 immature mandibular first molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis.
- Trial name
- NCT05581706
- Testing
- Place the freshly prepared calcium hydroxide in to the root canals, Place the freshly prepared double antibiotic paste in to the root canals, Taking standart periapical radiography with film holder
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ege University
Helicobacter Pylori Infection
Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy
The investigators aim at evaluating the efficacy of bovine lactoferrin addition to H. Pylori eradication regimens. 400 randomly distributed participants will be assigned to one of four treatment regimens of H.
- Trial name
- NCT04445948
- Testing
- Esomeprazole 40 milligrams Oral Tablet, Amoxicillin 1000 milligrams tablets, Clarithromycin 500 milligrams Tablets
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Alexandria University
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Physical Abilities, FMT
Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans
The intestinal microbiome is a microbial system that is influenced by host genetics and environmental exposures such as nutrition, stress and medications.
- Trial name
- NCT05024188
- Testing
- Antibiotics, Autologous Fecal Microbiota Transplantation, Cellules Pills
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Bacterial Vaginosis (BV)
LUXSOL(TM) Topical Cream for the Treatment of Symptomatic Bacterial Vaginosis; A Proof of Concept Study
LUXSOL Cream may be useful for the treatment of bacterial Vaginosis. In this study, LUXSOL Cream is compared to a control arm group using metronidazole cream.
- Trial name
- NCT02197182
- Testing
- LUXSOL copper containing cream, Metronidazole gel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- CDA Research Group, Inc.
Infection, Surgical Site Infection
Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056)
The purpose of this study is to evaluate the efficacy and safety of ertapenem sodium compared with ceftriaxone sodium/metronidazole for the prophylaxis of surgical site infection following elective colorectal surgery in Chinese…
- Trial name
- NCT01254344
- Testing
- ertapenem sodium, ceftriaxone sodium, metronidazole
- Volunteers
- 599 people
- Sponsor
- Merck Sharp & Dohme LLC
Premalignant Conditions, Malignant Lesions
To Evaluate the Best Metric for Inspection Time During a Diagnostic and/or Surveillance Upper Gastrointestinal Endoscopy (Age ≥ 18 Years, Informed Consent), Between Total Inspection Time Versus Withdrawal Time, for the Identification of Malignant Lesions
Gastric cancer is the fifth cause of cancer-related mortality worldwide. Gastric carcinogenesis involves the progression from premalignant conditions such as atrophic gastritis and intestinal metaplasia to premalignant lesions…
- Conditions
- Premalignant Conditions, Malignant Lesions, Gastric, Esophageal
- Trial name
- NCT06696209
- Testing
- Analysis of the withdrawal time of the Upper Gastrointestinal Endoscopy, Analysis of the total time of the Upper Gastrointestinal Endoscopy, Upper gastrointestinal endoscopy: Common Practices
- Where
- Portugal
- Volunteers
- 1,290 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Vaginosis, Bacterial
Safety and Tolerability of Metronidazole Gel 1.3%
Multicenter, open-label study to evaluate safety and tolerability of Metronidazole Vaginal Gel in females 12 to <18 years for the treatment of bacterial vaginosis.
- Trial name
- NCT02392026
- Testing
- Metronidazole Gel
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Insud Pharma
Helicobacter Pylori Infection
Fourteen-Day Vonoprazan-Based Dual Therapy With Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy
Background：Helicobacter pylori infection is a well-established risk factor for peptic ulcer disease and gastric cancer. It's now a consensus of experts that H.pylori infection should be treated once it is recognized.
- Trial name
- NCT06156085
- Testing
- Vonoprazan and Amoxicillin, Lansoprazole, Amoxicillin, Clarithromycin and Metronidazole
- Where
- Taiwan
- Volunteers
- 337 people
- Sponsor
- Fu Jen Catholic University Hospital
Pancreatoduodenectomy, PPPD
Duration of Perioperative Antibiotics in Pancreatoduodenectomy
The goal of this clinical trial is to compare two perioperative antibiotic prophylaxis regimens in adult patients undergoing pancreatoduodenectomy (PD) or pylorus-preserving pancreatoduodenectomy (PPPD).
- Conditions
- Pancreatoduodenectomy, PPPD, Infectious Complications
- Trial name
- NCT07043855
- Testing
- single dose preoperative antibiotic, Prolonged perioperative antibiotics
- Where
- South Korea
- Volunteers
- 558 people
- Sponsor
- Asan Medical Center
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