Clinical trials: Morphine, completed
Pediatric Acute Lung Injury
Pharmacologic Impact on Sedation Assessments
PISA is an ancillary study to the NIH funded clinical RESTORE Trial (U01 HL086622). This study will provide data that may allow for improved dosing recommendations in this critically ill population of children.
- Trial name
- PISA (NCT01105663)
- Testing
- Pharmacokinetic Sampling and pharmacogenetic analysis
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Philadelphia
Postoperative Pain
Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair
The aim of the study is to determine wether continuous wound infusion with local anaesthetic plus a single dose intravenous morphine is non-inferior to postoperative analgesia provided with continuous thoracic epidural infusion…
- Trial name
- APERIVIP (NCT02677532)
- Testing
- Paracetamol, Levobupivacaine wound infiltration, Levobupivacaine epidural bolus
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- University of Genova
Chronic Pain, Low Back Pain
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain
The primary objective of the study is to determine the analgesic efficacy and safety of ALO-02 extended-release capsules, when compared to placebo, in subjects with moderate to severe chronic low back pain.
- Conditions
- Chronic Pain, Low Back Pain, Analgesia
- Trial name
- NCT01571362
- Testing
- ALO-02
- Where
- 52 sites in United States
- Volunteers
- 410 people
- Sponsor
- Pfizer
Pain
Protocolized vs Discretionary Use of Opioids in Acute Pain
We are testing whether patients who received protocolized pain management (1 mg of IV hydromorphone followed by an additional 1 mg Intravenous (IV) hydromorphone 15 minutes later if the patients wants more) will have better pain…
- Trial name
- NCT00825370
- Testing
- Hydromorphone, IV opioid
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
The purpose of this study is to determine if intrathecal hydromorphone will relieve pain as well as intrathecal morphine after cesarean delivery, with fewer side effects.
- Trial name
- NCT01866254
- Testing
- Hydromorphone, Morphine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Shih, MD
Abdominal Cancer
Safety and Efficacy of Intrathecal Morphine in Children
Postoperative pain in pediatrics can usually be well controlled with a combination of analgesics including acetaminophen ( paracetamol) ,NSIADS, opioids , and local/regional anesthesia.The use of epidural and subarachnoid…
- Trial name
- NCT03120403
- Testing
- intrathecal morphine
- Volunteers
- 45 people
- Sponsor
- Alaa Ali Mohamed Elzohry
Pain
Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting
Unexpected acute pain in an emergency setting causes anxiety, insecurity, and stress that can diminish perceptions of control over pain and diminish ability to decrease pain.
- Trial name
- NCT01151696
- Testing
- Atarax (Hydroxyzine)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Toulouse
Tonsillitis, Post-operative Nausea and Vomiting (PONV)
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham.
- Conditions
- Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction
- Trial name
- NCT06326983
- Testing
- Dexmedetomidine, Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston Children's Hospital
Solitary Mass, Lung Diseases
Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia
The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.
- Trial name
- pain (NCT01236495)
- Testing
- spinal morphine 0.3 mg, spinal morphine 0.2 mg
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Postoperative Pain
Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy
to compare the analgesia and side effect of nalbuphine and morphine for elective Laparoscopic myomectomy.
- Trial name
- NCT03288428
- Testing
- Nalbuphine, Morphine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Postoperative Pain
Sufentanil for Anesthesia Induction in Continuous Remifentanil Anesthesia
The appropriate management of postoperative pain is recognized as an important clinical challenge with implications beyond humanitarian issues.
- Trial name
- SAIRA (NCT01777100)
- Testing
- Sufentanil
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Cancer
PROspective Non-interventional Open laBEl Trial for TARGIN in Korean Patients With Cancer Pain
The aim of the study is to evaluate the efficacy of TARGIN administration as an analgesic to Korean patients treated with opioid analgesics for moderate-to-severe cancer pain under conditions of daily practice.
- Trial name
- PROBE (NCT01719757)
- Testing
- Oxycodone/Naloxone
- Where
- South Korea
- Volunteers
- 359 people
- Sponsor
- Mundipharma Korea Ltd
Gingival Overgrowth
Assessment of Growth Factors Levels Associated with Wound Healing After Soft Tissue Crown Lengthening
Clinicians often encounter the need for crown lengthening in the practice of dentistry and have to make treatment decisions taking into consideration how to best address the biological, functional, and esthetic requirements of…
- Trial name
- NCT06806319
- Testing
- single intervention by Sirolase ® lower power diode laser 970 ± 15 nm (0.5 watts) continuous emission, power =3 watts, fiber 320 μm, single intervention by electrosurgical unit which was kept 38 watts rms ± 5%. The working frequency was adjusted to 1.5 MHz ± 5%.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Delirium
Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery
Investigators will assess the incidence and duration of postoperative delirium in patients ≥60 years old undergoing coronary artery bypass grafting (CABG), with/without valve surgery (aortic and/or mitral) based on different…
- Trial name
- DEXACET (NCT02546765)
- Testing
- IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pain, Pulmonary Nodules
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use…
- Conditions
- Pain, Pulmonary Nodules, Oxycodone
- Trial name
- NCT07484867
- Testing
- oxycodone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Retraction of Colostomy
A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B504
This study is designed to compare the standard of care against EXPAREL (bupivacaine liposome injectable suspension) to determine if total opioid consumption is reduced when using EXPAREL, therefore possibly reducing total…
- Trial name
- IMPROVE-IR (NCT01509807)
- Testing
- IV morphine sulfate or Sponsor-approved equivalent, EXPAREL
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Physiological Effect of Drugs, Morphine
Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine
The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for…
- Conditions
- Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid
- Trial name
- NCT04369950
- Testing
- 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain
Comparison of Surgical Rectus Sheath Block and Intrathecal Morphine
Pain is the main obstacle in delaying postoperative recovery and leads to prolonged hospital stay. Administration of intrathecal morphine during spinal anaesthesia can provide effective pain control.
- Trial name
- NCT02790099
- Testing
- Bupivacaine, Morphine
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Head and Neck Cancer, Radiation-Induced Mucositis
Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer
The purpose of this study is to compare the daily pain level scores for patients taking opioids alone for pain relief, compared with those treated by multimodal analgesia with three medications: pregabalin, naproxen, and…
- Trial name
- NCT04221165
- Testing
- Opioids, PAiN - multimodal analgesia
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post Thoracotomy Pain
Continuous Paravertebral Block by Intraoperative Direct Access Versus Systemic Analgesia for Postthoracotomy Pain Relief
to evaluate the safety and efficacy of continuous paravertebral block by intraoperative direct access on postthoracotomy pain compared to systemic analgesia.
- Trial name
- NCT04482192
- Testing
- Thoracic paravertebral block, Systemic analgesia
- Volunteers
- 63 people
- Sponsor
- Zagazig University
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