Clinical trials: Morphine
Provide Post Hepatectomy Pain Control
Bilateral External Oblique Intercostal Plane Block in Post Operative Pain Management in Hepatectomy
The majority of cases undergoing hepatectomy suffer from inadequate postoperative analgesia. Therefore, multimodal analgesic techniques are required to relieve pain and discomfort such as intravenous, and epidural analgesia, and…
- Trial name
- EOI (NCT06822309)
- Testing
- External Oblique Intercostal Plane Block, Patient controlled analgesia
- Volunteers
- 40 people
- Sponsor
- Sherif Alaa Embaby
Pain, Postoperative
Comparison of Post-operative Pain in Short Versus Long Stitch for Laparotomy Closure
Laparotomy is a surgical procedure where an incision is made through the abdominal wall in order to gain access to the peritoneal cavity. Midline laparotomy incisions were the main type of abdominal access.
- Trial name
- Shortstitch (NCT03828409)
- Testing
- Short stitch, Long stitch
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Pain, Postoperative
Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery
Background Postoperative pain is significant in cardiac surgical patients. Perioperative analgesia with intermittent administration of opioids can result in significant fluctuations in serum opioid concentrations.
- Trial name
- MethadoneRCT (NCT06728371)
- Testing
- Methadone, Morphine
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Cancer, Pain
Study Evaluating Safety and Tolerability of Oxycodone in Patients With Moderate to Severe Cancer Pain
This study is to evaluate the safety and tolerability of oxycodone control-released (CR) and/or immediate-released (IR) use in patients with moderate to severe cancer pain in a 3-months period in Taiwan.
- Trial name
- STOP Pain (NCT03176121)
- Testing
- Oxycodone
- Where
- 10 sites in Taiwan
- Volunteers
- 73 people
- Sponsor
- Taiwan Mundipharma Pharmaceuticals Ltd.
Orthopaedic Surgery
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery
The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain.
- Trial name
- NCT00822549
- Testing
- intravenous morphine titration
- Where
- France
- Volunteers
- 438 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Human Abuse Potential
Assessment of Abuse Potential of Cebranopadol in Humans
This study will be conducted to evaluate the abuse potential of single doses of cebranopadol as compared with oxycodone, tramadol and matching placebo in recreational drug users.
- Trial name
- NCT05256108
- Testing
- Oxycodone 40 mg, Tramadol 600 mg, Cebranopadol 600 µg
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Tris Pharma, Inc.
Post Laparotomy Pain Treatment
A Prospective Comparison of Methadone, Fentanyl, and Morphine for Post-laparotomy Epidural Analgesia
The current study aim is to compare between the opioids morphine, fentanyl and methadone in terms of efficacy and side effects profile when administered epidurally for pain management after laparotomies.
- Trial name
- NCT01828840
- Testing
- epidural morphine via PCEA, epidural fentanyl via PCEA, epidural methadone via PCEA
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Chronic Pain
Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain
Aim of this project is to customize the choice of the strong opioid in the treatment of cancer chronic pain through the identification of patient clinical history and pain characteristics, moreover in the analysis the…
- Trial name
- NCT00916890
- Testing
- Morphine, Oxycodone, Fentanyl
- Where
- 6 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pain
Analgesic Strategies in Newborns Receiving Prostaglandin Therapy
This is a randomised trial comparing the efficacy of 3 different analgesic strategies in newborns on prostaglandin for ductus dependent congenital heart disease.
- Trial name
- NCT00200590
- Testing
- acetaminophen and nalbuphine, acetaminophen and morphine, acetaminophen and reduced dosage of prostaglandin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Post Operative Pain
Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine
This study aims to compare the effect of pre-operative oral pregabalin on post operative morphine consumption after abdominal hysterectomy with/without salpingo-oophorectomy.
- Trial name
- NCT02285010
- Testing
- Pregabalin
- Where
- Thailand
- Volunteers
- 125 people
- Sponsor
- Mahidol University
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Hepatectomy, Analgesia
Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision
This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al.
- Conditions
- Hepatectomy, Analgesia, Nerve Block
- Trial name
- NCT02914015
- Testing
- Continous QLB (quadratus lumborum block), Philip CX50 Ultrasound Scanner, Ropivacaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cui Xulei
Postoperative Pain Management
Escalating Ketamine Doses and Pre-emption
Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures.
- Trial name
- NCT01070108
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain
Pain Therapy After Elective Cardiac Surgery
The purpose of this study is to determine generation of a target controlled infusion model for the patient controlled analgesia with the strong analgesic, hydromorphone, after planned open heart surgery, during which the strong…
- Trial name
- PKPDHM-001 (NCT01490268)
- Testing
- Sufentanil, Hydromorphone
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Post Operative Pain
Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia
It was proven that intrathecal opioids are considered as an effective means of pain control in several major surgical interventions including spine surgeries.
- Trial name
- NCT05338320
- Testing
- Ultrasound Guided Erector Spinae Plane Block, Intrathecal morphine, General anesthesia using intravenous fentanyl (1µg/kg)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Pain
A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain
Tapentadol has already been studied in adults. This study is needed to find out if tapentadol works and is safe to use in children and adolescents with long-term pain.
- Trial name
- NCT02151682
- Testing
- Tapentadol prolonged release, Morphine prolonged release
- Where
- 23 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 73 people
- Sponsor
- Grünenthal GmbH
Rhabdomyosarcoma
Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma
This phase I trial studies the side effects and best dose of mocetinostat when given together with vinorelbine to see how well it works in treating children, adolescents, and young adults with rhabdomyosarcoma that has spread to…
- Trial name
- NCT04299113
- Testing
- Vinorelbine, Mocetinostat
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Healthy, No Evidence of Disease
Effects of Garlic Supplements on Opioids in Healthy Volunteers
RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain.
- Trial name
- NCT00499460
- Testing
- garlic powder tablets, oxycodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Pulmonary Disease, Chronic Obstructive
Morphine for Treatment of Dyspnea in Patients With COPD
Dyspnea is the most reported symptom of patients with advanced Chronic Obstructive Pulmonary Disease (COPD) and is undertreated.
- Trial name
- MORDYC (NCT02429050)
- Testing
- sustained release morphine
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Urinary Stress Incontinence
Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia
The objective was to observe the satisfaction of local anesthesia during the implantation of the TVT-SECUR for the treatment of stress urinary incontinence, with the use of questionnaires completed by the patients, and to…
- Trial name
- NCT00904618
- Testing
- TVT-SECUR - 'Hammock' technique, TVT-SECUR - 'U-Method', Local anesthesia (30 to 40 ml of a mixture of 35 ml of lidocaine 2% and 5 ml of bicarbonate 3%).
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke