Clinical trials: Morphine, completed
Retraction of Colostomy
A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501
This study is designed to compare the standard of care against EXPAREL (bupivacaine liposome injectable suspension) to determine if total opioid consumption is reduced when using EXPAREL, therefore possibly reducing total…
- Trial name
- IMPROVE-IR (NCT01509638)
- Testing
- Group 1 Standard of Care, Group 2 EXPAREL
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Chronic Obstructive Pulmonary Disease, Dyspnea
Breathlessness Exertion and Morphine Sulphate
Breathlessness is an overwhelming symptom affecting tens of thousands of Australians every day. For many people, it persists even when all the underlying causes have been optimally managed (chronic breathlessness).
- Trial name
- BEAMS (NCT02720822)
- Testing
- Morphine Sulfate, Plus laxative (Docusate with senna), FitBit charge HR (Accelerometer)
- Where
- 15 sites in Australia, New Zealand
- Volunteers
- 171 people
- Sponsor
- Flinders University
Pregnancy, Ceasarian Section, Anaesthesia
Transversus Abdominis Plane Block Versus Spinal Morphine After Caesarean Section : A Comparison Study
Many counties in sub-Saharan Africa have very limited post-operative nursing capacity, and relatively little data have been published about post-operative maternal pain control in these settings.
- Trial name
- NCT03263689
- Testing
- Intrathecal morphine
- Volunteers
- 130 people
- Sponsor
- Mbarara University of Science and Technology
Scoliosis, Pain
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
Acute pain management following major surgical procedures in pediatric patients continues to be a challenge, especially after extensive posterior spine fusions.
- Trial name
- NCT02558010
- Testing
- Methadone, Normal Saline, Morphine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Medical College of Wisconsin
Abdominal Cancer
Efficacy of Transverses Abdominis -Plane Block With Bupivacaine Versus Bupivacaine With Morphine Postoperatively
This study aims to compare the analgesic efficacy of transversus abdominis-plane block with bupivicaine versus bupivacaine with morphine in patients undergoing major abdominal cancer surgery.
- Trial name
- NCT02566096
- Testing
- transversus abdominis-plane block with local anesthetic 20 ml of bupivacaine 0.5% + 10 mg morphine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain, Opioid Dependence
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Each year, in the U.S. alone, >6 million children undergo painful surgery; up to 50% of them experience significant and serious side effects with opioids and inadequate pain relief.
- Trial name
- NCT03495388
- Testing
- Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Senthil Sadhasivam
Postoperative Pain, Acute
Serratus Posterior Superior Intercostal Plane Block
Background: Adequate pain control after video-assisted thoracoscopic surgery (VATS) remains a major clinical challenge. Traditional techniques such as thoracic epidural analgesia are effective but limited by potential…
- Trial name
- NCT07330479
- Testing
- Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block, Subcutaneous Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Gaziantep
Pain, Postoperative, Coronary Artery Disease
Pecto-Intercostal Fascial Block vs. Transversus Thoracic Muscle Plane Block in Cardiac Surgery
In patients undergoing open cardiac surgery, pain control is an essential part of the enhanced recovery process. The current study aimed to evaluate the analgesic efficacies of ultrasound-guided pecto-intercostal fascial block…
- Trial name
- NCT04791592
- Testing
- Single-injection, ultrasound-guided bilateral PIF block., Single-injection, ultrasound-guided bilateral TTMP block.
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain
Surgicel and Analgesic Reservoir
Laparoscopic cholecystectomy (LC) is a widespread surgical procedure with superior outcomes in terms of the incurred postoperative pain, recovery time, cosmetic, and morbidity issues.
- Trial name
- NCT03730714
- Testing
- "Local Anesthetic", "Epinephrine" and "Morphine", "Local Anesthetic", "Epinephrine", "Morphine" and "Surgicel", "Normal Saline"
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Heroin Dependence, Opioid-Related Disorders
Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
The purpose of this study is to determine whether the opportunity to take free supplemental hydromorphone (HYD) influences drug seeking behavior in heroin dependent individuals.
- Trial name
- NCT00218309
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Acute Coronary Syndromes
Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine
- Trial name
- NCT00718406
- Testing
- Metoprolol, metoprolol plus morphine
- Where
- Sweden
- Sponsor
- Sahlgrenska University Hospital
Postoperative Pain, Knee Replacement Arthroplasty
Management of Postoperative Pain After Total Knee Replacement.
The purpose of this study is to compare two methods of postoperative pain management in patients undergoing total knee replacement.
- Trial name
- NCT01163214
- Testing
- Nerve Block, Periarticular Injection
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Mark J. Spangehl, M.D.
Healthy Volunteers
Analgesic Tolerance to Repeated Doses of Subcutaneous Morphine
30 healthy volunteers will be enrolled in this 6-session study. The first visit will be a screening/orientation session. The next 5 visits will be (full day) outpatient sessions taking place Monday through Friday during one week.
- Trial name
- NCT00256347
- Testing
- intramuscular injections of morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bronchiectasis Post-Tuberculosis Lung Disease
Respiratory Muscle Stretching Exercise for Improving Quality of Life of Patients With Bronchiectasis
Bronchiectasis is a chronic condition often arising after the successful treatment of lung tuberculosis, leading to diminished functional exercise capacity, increased fatigue, and reduced quality of life.
- Trial name
- NCT06722547
- Testing
- Standard PR, Standard PR plus Respiratory Muscle Stretching
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Padjadjaran
Laparoscopic Colorectal Surgery, Postoperative Analgesia
Effect of Oliceridine Analgesia on Postoperative Nause and Vomiting
Postoperative nausea and vomiting (PONV) is common after surgery and impede rapid recovery after surgery. Patients who undergo laparoscopic colorectal surgery are more likely to develop PONV due to the pneumoperitoneum…
- Conditions
- Laparoscopic Colorectal Surgery, Postoperative Analgesia, Oliceridine, Morphine
- Trial name
- NCT06411665
- Testing
- Oliceridine, Morphine
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking University First Hospital
Multiple Sclerosis
A Study of Dimethyl Fumarate (DMF) in Relapsing Forms of Multiple Sclerosis (RMS) Participants in China
The primary objective of the study is to assess the efficacy of DMF in Chinese participants with RMS at Week 48. The secondary objectives of the study are to assess the efficacy and safety of DMF in Chinese participants with RMS.
- Trial name
- NCT05658484
- Testing
- Dimethyl fumarate
- Where
- 15 sites in China
- Volunteers
- 60 people
- Sponsor
- Biogen
Cognitive Dysfunction
Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers
Dexmedetomidine is a drug with sedative, anxiolytic, and analgesic properties. Benefits of its use covers good sedations without respiratory suppression, reduced circulating catecholamines due to decreased sympathetic…
- Trial name
- NCT03585452
- Testing
- Dexmedetomidine Infusion, Propofol based general anesthesia
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Michał Kowalczyk
Pain
Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
The aims of this study are to assess efficacy and safety of patient-controlled analgesia (PCA) when applied to the Emergency Department setting and to compare the efficacy and safety of two PCA dosing regimens.
- Trial name
- NCT00910208
- Testing
- Patient-controlled analgesia, morphine
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Albert Einstein College of Medicine
Analgesic Drug Dependence, Sensory Deficit
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering
Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal volunteers, and patients…
- Trial name
- NCT03375216
- Testing
- sensory testing (Heat, cold, and pressure), Promis Survey
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
ST-segment Elevation Myocardial Infarction, Non-ST-segment Elevation Myocardial Infarction
Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction
The purpose of the IMPRESSION study is to determine whether intravenous administration of morphine prior to ticagrelor administration in ST-segment elevation myocardial infarction (STEMI) patients and in non-ST-segment elevation…
- Conditions
- ST-segment Elevation Myocardial Infarction, Non-ST-segment Elevation Myocardial Infarction, VA Drug Interactions
- Trial name
- IMPRESSION (NCT02217878)
- Testing
- Morphine, Ticagrelor
- Where
- Poland
- Volunteers
- 74 people
- Sponsor
- Collegium Medicum w Bydgoszczy
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