Clinical trials: Morphine, completed
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Postoperative Pain, Hysterectomy
Comparison of Butorphanol and Tramadol Associated Patient-Controlled Analgesia (PCA) After Hysterectomy
Intravenous patient-controlled analgesia (PCA) is a popular technique for postoperative pain management. Although several drugs are recognized as effective therapeutic options, optimal selection of drugs in hysterectomy patients…
- Trial name
- BATPCAH (NCT00510666)
- Testing
- Saline, Butorphanol tartrate, Tramadol Hydrochloride
- Where
- China
- Volunteers
- 841 people
- Sponsor
- Nanjing Medical University
Pain Management, Paravertebral Block
CTPVB for Hepatectomy
Moderate to severe postoperative pain often influence patients quality of recovery after hepatectomy. Systemic opioids given with patient-controlled analgesia has been used after hepatectomy in many medical center, but the…
- Conditions
- Pain Management, Paravertebral Block, Hepatectomy
- Trial name
- NCT03990922
- Testing
- Continuous Paravertebral block with ropivacaine, Continuous Paravertebral "block" with saline, Patient-controlled analgesia with morphine
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Cui Xulei
Anesthesia, Regional Anesthesia
Laparoscopic Sleeve Gastrectomy Surgery and External Oblique Intercostal Block
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Morbid Obesity, Postoperative Pain
- Trial name
- NCT05822479
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Major Depressive Disorder
Comparative Effectiveness Clinical Trial of MST Compared to ECT in Major Depressive Disorder
This study was a prospective, open-label comparative effectiveness clinical trial, comparing magnetic seizure therapy (MST) to ECT in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT04216095
- Testing
- Electroconvulsive Therapy (n=30), Magnetic Seizure Therapy (n=30)
- Volunteers
- 60 people
- Sponsor
- Tanta University
Intensive Care, Neonatal, Analgesia
Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in clonidine administered for analgesia and sedation to preterm newborn infants receiving…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT04928651
- Testing
- Clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Labor Pain, Early Labor
Therapeutic Rest to Delay Admission in Early Labor: A Prospective Study on Morphine Sleep
This will be a prospective study on labor characteristics, and obstetric and neonatal outcomes in women who accept and women who decline morphine as a form of pain management in labor.
- Trial name
- NCT03539562
- Testing
- Morphine Sulfate and Promethazine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Interstitial Lung Disease, Dyspnea
Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease
36 patients with interstitial lung disease will be randomized to 1 weeks treatment with morphine hydrochloride as oral linctus 5 mg, four times a day, and 5 mg as needed up to 4 times a day, or corresponding doses of placebo.
- Conditions
- Interstitial Lung Disease, Dyspnea, Morphine
- Trial name
- MORPHILD (NCT02622022)
- Testing
- Morphine hydrochloride
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Low Back Pain
Post-operative Epidural Analgesia After Minimally Invasive Lumbar Decompression and Fusion
Minimally invasive (MIS) lumbar decompression and fusion is a new procedure that aims to reduce post-operative pain, opioid consumption and related side effects, and length of hospital stay.
- Trial name
- NCT00644111
- Testing
- Bupivicaine, Hydromorphone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Spinal Manipulation
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.
- Trial name
- NCT02550132
- Testing
- Spinal manipulation, Apparatus used to deliver spinal manipulations
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Pain
Single Dose Pharmacokinetics of Egalet® Hydrocodone
The purpose of the study is to evaluate the pharmacokinetic profile of different Egalet® hydrocodone formulations and compare to a marketed hydrocodone drug.
- Trial name
- NCT00802087
- Testing
- hydrocodone, hydrocodone & acetaminophen combination
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Itch
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
The aim of our 2nd sub-project is to clarify if the capsaicin receptor TRPV1 is implicated in the mechanism of morphine-induced mast cell degranulation.
- Trial name
- NCT04700007
- Testing
- Capsaicin, Diphenhydramine, Morphine Chloride
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal
Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome
Randomized pilot trial comparing scheduled morphine dosing with a weaning protocol to intermittent morphine dosing on an as-needed basis for newborns with neonatal abstinence syndrome.
- Conditions
- Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
- Trial name
- NCT04298853
- Testing
- Morphine PRN, Morphine scheduled
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Postoperative Pain, Breast Cancer
The Effect of Double Injection Erector Spinae Plane Block on Postoperative Pain Following Breast Surgery
Postoperative analgesia in breast surgery is a difficult and overworked issue due to extensive surgery and complex innervation of the breast.
- Trial name
- NCT03415646
- Testing
- Erector Spinae Plane Block, Intravenous Morphine patient controlled analgesia device
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Drug Interaction Potentiation, Myocardial Infarction
Drug Drug Interactions of Aspirin and P2Y12-inhibitors
Study Objective: To investigate potential drug-drug interactions (pharmacokinetics and pharmacodynamics) of morphine and antiplatelet drugs (aspirin, clopidogrel, prasugrel, ticagrelor)
- Trial name
- NCT01369186
- Testing
- Morphine
- Where
- Austria
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Post-operative Pain, Osteoarthritis
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
The purpose of this study is to determine the contribution of spinal epimorph to patient's perioperative pain management in Total Knee Arthroplasty (TKA).
- Trial name
- NCT01667445
- Testing
- Epimorph, Spinal analgesia
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Pain
Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty
The aim of this study is to assess the effectiveness of Sublingual Sufentanil Tablets System (SSTS, Zalviso ®) to control postoperative pain after total knee arthroplasty in the context of early rehabilitation program.
- Trial name
- NCT04448457
- Testing
- Sufentanil Sublingual Tablet, Oxycodone oral tablet and oxycodone extended-release oral tablet
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire de Tivoli
Opioid Use, Unspecified
Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
Hair analysis is a well-established and important tool in both forensic and clinical context. When it comes to the interpretation of positive hair analysis results, reliable and comprehensive reference data is essential.
- Trial name
- NCT05740657
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Cancer
Diamorphine or Alfentanil for Subcutaneous Use in Hospice In-patients?
OBJECTIVES: How does Alfentanil compare with the standard drug Diamorphine for subcutaneous analgesia in the palliative care setting? STUDY DESIGN: An open-label pilot comparison between alfentanil and diamorphine for palliative…
- Trial name
- DASH (NCT01049672)
- Testing
- Alfentanil, Diamorphine
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Healthy
Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fasted Conditions
The objective of this single-dose, open-label, randomized, two-treatment, two-period crossover study was to compare the relative bioavailability of a test formulation of KADIAN (2 x 10 mg) capsules manufactured by Alpharma Inc.
- Trial name
- NCT00759902
- Testing
- morphine sulfate extended-release capsules, KADIAN (morphine sulfate extended-release) capsules
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
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