Clinical trials: Mycophenolate Mofetil
Transplantation, Renal, Immunosuppression
MPA PK Monitoring Strategy With MMF/FK Based Immunosuppression
Individuals absorb Cellcept (MMF/Mycophenolate Mofetil) at different rates and it is difficult to determine an individuals level of Mycophenolate Mofetil (MMF, trade name Cellcept)from a single measurement.
- Trial name
- NCT00187941
- Testing
- Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida
Atopic Dermatitis
Registry for Systemic Eczema Treatments
The Registry for Systemic Eczema Therapies (RESET) registry is a database and biospecimen repository for patients with pediatric-onset atopic dermatitis (AD) who have used or will initiate any systemic treatment(s) for AD.
- Trial name
- RESET (NCT06136767)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Kidney Transplantation
To Compare the Efficacy and Safety of a Therapy of Tacrolimus With Sirolimus or MMF in Kidney Transplantation.
Primary objective of this study is to compare the two therapy regimens with regard to renal function by using calculated creatinine clearance.
- Trial name
- RESTORE (NCT00296361)
- Testing
- Tacrolimus
- Where
- 59 sites in Australia, Austria and 12 more
- Volunteers
- 634 people
- Sponsor
- Astellas Pharma Inc
Focal Segmental Glomerulosclerosis
Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis
The aim of this clinical trial is to determine the effect and security of low-dose Prednisone Combined With MMF and FK506 in Focal Segmental Glomerulosclerosis.
- Trial name
- NCT00956059
- Testing
- prednisone, FK506, MMF, prednisone
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xi'an Jiaotong University
Disorder Related to Renal Transplantation
A Phase II Study of Belatacept (BMS-224818) With a Steroid-free Regimen in Subjects Undergoing Kidney Transplantation
The purpose of this clinical research study is to learn if belatacept (BMS-224818) is expected to show acceptable rates of acute rejection (AR) in steroid-free belatacept-based immunosuppressive regiments compared to a similar…
- Trial name
- NCT00455013
- Testing
- Thymoglobulin, Belatacept, Sirolimus
- Where
- 17 sites in United States, Italy and 1 more
- Volunteers
- 93 people
- Sponsor
- Bristol-Myers Squibb
Kidney Transplantation, Chronic Kidney Disease
Calcineurin Free Immunosuppression in Renal Transplant Recipients
The main purpose of this study is to obtain preliminary information on the efficacy, safety and cost of two regimens, Rapamycin / MMF / steroid therapy and Cyclosporine A Neoral / MMF / steroid therapy, used in the prevention of…
- Trial name
- NCT00812123
- Testing
- Sirolimus, Cyclosporine A, Prednisone
- Where
- Switzerland
- Volunteers
- 127 people
- Sponsor
- University Hospital, Basel, Switzerland
Liver Transplantation
Low Dose Thymoglobulin to Protect Kidney Function After Liver Transplant
This study will evaluate the use of a drug called Thymoglobulin, combined with a delayed start of the anti-rejection drugs (10 days after liver transplant), compared to the current approach of starting anti-rejection drugs called…
- Trial name
- NCT00970073
- Testing
- Thymoglobulin 3mg total, Thymoglobulin 4.5mg total, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Cytomegalovirus Infections
Evaluation of Early Use of Everolimus (EVE) on Cytomegalovirus (CMV) Infection in Renal Transplant Recipients
CMV infection is common in transplant patients and can cause graft loss. CMV is a major factor in increasing morbidity, and post-transplant costs.
- Trial name
- NCT01927588
- Testing
- Everolimus+Tacrolimus+Prednisone, Mycophenolate+Tacrolimus+Prednisone
- Volunteers
- 50 people
- Sponsor
- Fundação Pró Rim
Healthy Volunteers
Identification of Drug-drug Interaction Between Tacrolimus and Mycophenolate Mofetil in Healthy Adults
Coadministration of tacrolimus and mycophenolate mofetil is frequent in kidney transplantation. Due to narrow therapeutic range of tacrolimus and mycophenolate mofetil, therapeutic drug monitoring with dose adjustment is…
- Trial name
- NCT02743247
- Testing
- Tacrolimus, Mycophenolate mofetil
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Kidney Transplantation, Antibody-mediated Rejection
CD38 mAb Induction + Azathioprine Maintenance for Chronic Active AMR in Kidney Transplant Recipients
This multicenter, prospective, single-arm exploratory study evaluates the efficacy and safety of a novel sequential regimen for chronic active antibody-mediated rejection (caABMR) in kidney transplant recipients: single-dose CD38…
- Trial name
- CAZA (NCT07718308)
- Testing
- CD38, Azathioprine (AZA), Standard Triple Immunosuppression Maintenance
- Volunteers
- 20 people
- Sponsor
- wujianyong
Sjogren's Syndrome
Efficacy and Safety of Mycophenolate Mofetil in subjectswithSjogren's Syndrome
Past literature showed encouraging effects of mycophenolate on dryness symptoms and quality of life in patients with Sjogren's syndrome. Mycophenolate also has excellent immunomodulation effects in lupus nephritis.
- Trial name
- NCT02691949
- Testing
- Mycophenolate mofetil
- Volunteers
- 54 people
- Sponsor
- Kaohsiung Medical University
Kidney Transplantation
Evaluation of the Therapeutic Benefit of an Initial Intensified Dosing Regimen of Mycophenolate Sodium Versus a Standard Regimen in Renal Transplant Patients
The purpose of this study is to determine if an initial intensified enteric-coated mycophenolate sodium (Myfortic) dosing regimen administered during the first six weeks post renal transplantation provides improved efficacy, with…
- Trial name
- NCT00419926
- Testing
- Enteric-coated mycophenolate sodium (Myfortic), Cyclosporine (Neoral), Prednisone
- Where
- Switzerland
- Volunteers
- 313 people
- Sponsor
- Novartis
Kidney Transplantation, Primary Prevention
Renal Function Evaluation After Reduction of Cyclosporine A Dose in Renal Transplant Patients
The purpose of the study is to show the efficacy of reduction of cyclosporine A exposure measured by the area under the curve by Bayesian estimator on the primary prevention of degradation of the renal function in renal…
- Conditions
- Kidney Transplantation, Primary Prevention, Kidney Failure
- Trial name
- DICAM (NCT00213590)
- Testing
- cyclosporine A
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Liver Transplantation
Reduction in the Risk of Rejection by Mycophenolate Mofetil Dose Adjustment in Liver Transplant Patients With Side Effects Caused by the Calcineurine Inhibitors
The aim of this project is to determine whether, in liver transplant patients with side effects due to ICN, the use of MMF in monotherapy can be optimised by dose adjustment based on the area under the curve (AUC) of mycophenolic…
- Trial name
- MONOCEPT (NCT00456235)
- Testing
- Mycophénolate Mofétil, Ciclosporine A, Tacrolimus
- Where
- 17 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Limoges
Leukemia, Lymphoma
Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, monoclonal antibodies, and radiation therapy before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00085449
- Testing
- alemtuzumab, cyclosporine, fludarabine phosphate
- Where
- 24 sites in United States
- Sponsor
- Alliance for Clinical Trials in Oncology
Liver Transplantation
Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA (Enteric Coated Mycophenolic Acid) Following Liver Transplantation
This is an investigator initiated study at the University of California, Los Angeles (UCLA) funded by Novartis looking at using a combination of immunosuppressive drugs in liver transplant patients that are at risk of developing…
- Trial name
- NCT02123108
- Testing
- Basiliximab, Tacrolimus, Mycophenolic Acid
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Los Angeles
Liver Disease, Liver Transplantation
Immune System Suppression With Alemtuzumab and Tacrolimus in Liver Transplantation Patients
Alemtuzumab is a man-made antibody used to treat certain blood disorders. Tacrolimus is a drug used to decrease immune system activity in people who have received organ transplants so that the new organ will not be rejected.
- Trial name
- TILT (NCT00105235)
- Testing
- Alemtuzumab, Cyclosporine, Mycophenolate mofetil
- Where
- 9 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia
Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This phase II trial studies how well fludarabine phosphate with radiation therapy and rituximab followed by donor stem cell infusions work in treating patients with high-risk chronic lymphocytic leukemia (CLL) or small…
- Conditions
- Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia
- Trial name
- NCT00104858
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate
- Where
- 5 sites in United States, Denmark and 1 more
- Volunteers
- 66 people
- Sponsor
- Fred Hutchinson Cancer Center
Kidney Transplantation
Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
The purpose of this study is to determine whether treatment with sirolimus, in combination with low-dose tacrolimus and prednisone, is effective for the treatment of chronic allograft nephropathy (progressive scarring) in…
- Trial name
- NCT00188955
- Testing
- sirolimus
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Adult Acute Lymphoblastic Leukemia in Complete Remission, Acute Myeloid Leukemia in Remission
Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia
This phase I trial studies the side effects and best dose of total bone marrow and lymphoid irradiation when given together with chemotherapy before donor stem cell transplant in treating patients with myelodysplastic syndrome or…
- Conditions
- Adult Acute Lymphoblastic Leukemia in Complete Remission, Acute Myeloid Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Recurrent Adult Acute Lymphoblastic Leukemia
- Trial name
- NCT02446964
- Testing
- Bone Marrow Transplantation, Cyclophosphamide, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- City of Hope Medical Center