Clinical trials: Omeprazole
Helicobacter Pylori Infection
Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori
The eradication rate of standard quadruple therapy has become less successful due to low compliance and high resistance to the antibiotics.
- Trial name
- NCT03688828
- Testing
- Saccharomyces boulardii, Esomeprazole, Amoxicillin
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huazhong University of Science and Technology
GERD
A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects
A Study to compare pharmacokinetics and safety of CKD-381 and D026 in healthy male subjects
- Trial name
- NCT03444402
- Testing
- CKD-381(formulation I), CKD-381(formulation II), D026(Nexium 40mg)
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Helicobacter Pylori Infection
Safety and Efficacy Study of a Non-antibiotic Treatment for the Eradication of Helicobacter Pylori
At present, triple therapy is recommended by various guidelines for the treatment of Helicobacter pylori (H.pylori) infection. Recent studies have shown increasing resistance of H.pylori to commonly used antibiotics used in…
- Trial name
- NCT01109381
- Testing
- GT08
- Where
- Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Synergy Pharmaceuticals Pte. Ltd.
Healthy Adult Subjects
A Pharmacokinetic Study to Evaluate the Bioequivalence of a Test Formulation Compared to an Equivalent Dose of a Reference Drug Product
To assess the bioequivalence of esomeprazole of the TEST product vs. the REFERENCE product in healthy volunteers who reside in Taiwan.
- Trial name
- NCT02444507
- Testing
- Nexium powder for injection and infusion 40 mg, Esomelone Powder for Solution for Injection / Infusion 40 mg
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- isRed Pharma & Biotech Research Corporation
Gastric Ulcer, Chronic Gastritis
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline…
- Conditions
- Gastric Ulcer, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT03609892
- Testing
- Berberine, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Critical Illness
Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.
Upper gastrointestinal (GIT) bleeding is common in high risk critically ill patients. Hyperacidity has been identified as one of the main reasons for bleeding.1 2 Antacids with different treatment modalities have been studied to…
- Trial name
- NCT03388463
- Testing
- Omeprazole
- Volunteers
- 110 people
- Sponsor
- Menoufia University
Orbital Pseudotumor
Intraorbital Injection Versus Oral Steroid in Anterior Idiopathic Orbital Inflammation
A multicenter randomised double-arm clinical trial, to compare safety and efficacy of oral versus intralesional injection of steroid in a group of patients suffering from idiopathic orbital inflammation is designed.
- Trial name
- NCT03958344
- Testing
- Prednisolone, Triamcinolone + Betamethason
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Iran University of Medical Sciences
Upper Gastrointestinal Bleeding
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage.
- Trial name
- NCT00045799
- Testing
- Omeprazole sodium bicarbonate immediate release PWD/FS, Cimetidine IV
- Where
- 58 sites in United States
- Volunteers
- 354 people
- Sponsor
- Bausch Health Americas, Inc.
Tuberculosis
Phenotyping of High Dose Rifampicin
Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future.
- Trial name
- PHENORIF (NCT04525235)
- Testing
- phenotyping cocktail, rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Anastomotic Stricture, Morbid Obesity
Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
The purpose of this study is to determine whether suppressing acid production by administration of daily proton pump inhibitors in the early post-operative period will reduce the gastrojejunal anastomosis stricture rate in…
- Trial name
- NCT00361985
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori in Children
This study is designed to compare the eradication rates，safety and compliance of tailored therapy to those of standard triple therapy in children with H. pylori infection.
- Trial name
- NCT02635191
- Testing
- Tailored Group, Standard group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Precancerous Gastric Lesions
A Randomized Multi-Intervention Trial to Inhibit Precancerous Gastric Lesions in Lingu, Shandong Province
The Division of Cancer Epidemiology and Genetics is conducting a collaborative randomized multi-intervention trial with the Beijing Institute for Cancer Research to evaluate the etiologic role of Helicobacter pylori, garlic, and…
- Trial name
- NCT00339768
- Testing
- Amoxicillin/omeprazole
- Where
- China
- Volunteers
- 3,411 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Participants
A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants
The primary purpose of this study is to evaluate the potential of gastric pH-dependent drug-drug interaction effect of esomeprazole, a proton pump inhibitor (PPI), on the pharmacokinetics (PK) of emraclidine in healthy adult…
- Trial name
- NCT06366243
- Testing
- Emraclidine, Esomeprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Healthy
Effect of Inhibitors of the Proton Pump on Intestinal Transporters
Dabigatran etexilate is a novel oral anticoagulant. It is indicated in venous thromboembolic prevention in orthopedic surgery and has recently shown greater efficiency and tolerance as anticoagulants in preventing thromboembolism…
- Trial name
- BIPP (NCT02524210)
- Testing
- Dabigatran, Rabeprazole and Dabigatran, Omeprazole and Dabigatran
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Helicobacter Pylori Infection
Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy
Doxycycline- and Furazolidone-containing Quadruple Regimen can be a successful rescue treatment for Helicobacter pylori Infection patients after Failure of several therapy.
- Trial name
- NCT02894268
- Testing
- Doxycycline, Furazolidone, Esomeprazole
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sir Run Run Shaw Hospital
Gastroesophageal Reflux Disease (GERD)
Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
The study objective is to evaluate the relative merits, safety and effectiveness of Transoral Incisionless Fundoplication (TIF) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs).
- Trial name
- TvP (NCT00857597)
- Testing
- Transoral Incisionless Fundoplication, Proton Pump Inhibitors; active control
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
GERD
A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects
A Study to compare Pharmacokinetics, Pharmacodynamics and safety of CKD-381 and D027 in healty subjects
- Trial name
- NCT03211143
- Testing
- CKD-381, Nexium
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux Disease
SThe Effects of Melatonin on GERD Symptoms
We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by decreasing esophageal acid exposure and esophageal acid sensitivity in GERD.
- Trial name
- NCT00564590
- Testing
- Melatonin, omeprazole
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori
A Study of Vonoprazan in Adults With Helicobacter Pylori
Helicobacter Pylori (H Pylori) is a bug found in the digestive system. It can cause soreness and redness in the stomach (gastritis). It can also cause ulcers in the stomach and other parts of the digestive system.
- Trial name
- NCT04753437
- Testing
- Clarithromycin, Amoxicillin, Bismuth potassium citrate
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Takeda
Drug Use
Bioequivalence Study of 20 mg Omeprazole Capsules in Indonesia Healthy Subject
The study was conducted to investigate whether 20 mg omeprazole capsules manufactured by PT. Dankos Farma for PT. Hexpharm Jaya is bioequivalent to its reference product, 20 mg Losec® capsules manufactured by AstraZeneca AB…
- Trial name
- NCT05849883
- Testing
- Omeprazole 20 mg Capsules
- Where
- Indonesia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- PT Kalbe Farma Tbk
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