Clinical trials: Ondansetron
Hypotension (MeSH: D007022), Bradycardia
Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it is frequently complicated by maternal hypotension and bradycardia.
- Trial name
- NCT07883772
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Aydin Adnan Menderes University
PONV
Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study is a randomized controlled clinical trial focusing on the prevention of postoperative nausea and vomiting (PONV), planned to start in May 2026 and end in April 2027.
- Trial name
- NCT07891312
- Testing
- Amisulpride, Ondansetron
- Volunteers
- 718 people
- Sponsor
- Qianfoshan Hospital
Hypotension, Spinal Anesthesia
Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby.
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT07886151
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Cholera (Disorder)
Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera
This Phase IIa randomized controlled trial will evaluate whether a single oral dose of ondansetron can reduce oral rehydration failure in children and adolescents with suspected or confirmed cholera and active vomiting.
- Trial name
- NCT07795060
- Testing
- Ondansetron, Standard Cholera Care
- Where
- Republic of the Congo
- Volunteers
- 120 people
- Sponsor
- Public Interest Science Center
Spinal Anesthesia-Induced Hypotension, Cerebral Oxygenation
Effects of Ondansetron Timing During Spinal Anesthesia for Urologic Surgery
This study will evaluate whether the timing of intravenous ondansetron administration affects cerebral oxygenation and hemodynamic stability in older adults undergoing endoscopic urologic surgery under spinal anesthesia.
- Trial name
- NCT07858149
- Testing
- Ondansetron 8 mg, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Istanbul University
Healthy Volunteers
Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers
This study looks at how to reduce nausea and vomiting in people taking KarXT which is used to treat mental health conditions like schizophrenia.
- Trial name
- NCT07681076
- Testing
- KarXT, Trimethobenzamide, Ondansetron
- Where
- 4 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Overweight, Obesity
A Trial to Evaluate Interactions Between Antiemetic Medication and AMG 133 in Participants Living With Overweight or Obesity
The primary objective of this trial is to evaluate the pharmacokinetics (PK) of AMG 133 administered alone and in combination with an antiemetic medication, ondansetron, in participants living with overweight or obesity.
- Trial name
- NCT07310563
- Testing
- AMG 133, Ondansetron
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Amgen
Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV)
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV), Postoperative Nausea and Vomiting
- Trial name
- NCT07868861
- Testing
- NS003 Ondansetron HCl microspheres powder for nasal application, Ondansetron Solution for IV infusion 8mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia
Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia
The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing…
- Conditions
- Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia, Ceserean Section, Antiemetic Therapy
- Trial name
- NCT07740577
- Testing
- Ondansetron 4mg, metoclopramide
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Education and Research Hospital
Nausea and Vomiting Chemotherapy-Induced, Nausea Post Chemotherapy
Study With IV NEPA (Fosnetupitant/Palonosetron) for the Prevention of Chemotherapy-induced Nausea and Vomiting in Paediatric Cancer Patients Undergoing Highly Emetogenic Chemotherapy (HEC)
Chemotherapy often causes nausea and vomiting (CINV), and this is a major problem for the children being treated for cancer. To prevent this, a combination of two substances in fixed proportion (IV NEPA) was developed.
- Trial name
- NCT06904235
- Testing
- IV NEPA (fosnetupitant/palonosetron), Reference Treatment: IV ondansetron infusion, Reference Treatment: IV fosaprepitant infusion
- Where
- 20 sites in Greece, Poland and 2 more
- Volunteers
- 95 people
- Sponsor
- Helsinn Healthcare SA
Vomiting, Nausea
Inhaled Isopropyl Alcohol for Treatment of Nausea
To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.
- Conditions
- Vomiting, Nausea, Children, Only
- Trial name
- NCT05418244
- Testing
- Inhaled Isopropyl Alcohol, Oral Ondansetron
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Nephrotoxicity
Cisplatin Disposition and Kidney Injury
This study is being done to determine 1) whether drugs to treat cisplatin-related nausea can influence harm to the kidneys, 2) whether cisplatin levels in the body can influence the risk of harm to the kidneys, and 3) whether a…
- Trial name
- NCT03817970
- Testing
- Granisetron, Ondansetron, Palonosetron
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
Postoperative Shivering, Postspinal Shivering
Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering
This randomized controlled trial assessed whether intravenous ondansetron is more effective than low dose ketamine in preventing shivering after spinal anesthesia in adults undergoing elective surgery.
- Trial name
- NCT07334223
- Testing
- ondansetron, Ketamine (0.25 mg/kg)
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore
Esophagogastroduodenoscopy, Upper Gastrointestinal Bleeding (UGIB)
Effect of Ondansetron on Patient Tolerance, Efficacy and Endoscopist Workload in Unsedated Endoscopy for Upper Gastrointestinal Bleeding
The goal of this clinical trial is to evaluate whether intravenous ondansetron can improve patient tolerance and reduce discomfort during unsedated emergency esophagogastroduodenoscopy (EGD).
- Trial name
- NCT07336680
- Testing
- intravenous ondansetron
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Obesity, Morbid, Surgery
Multimodal Analgesia Effect on Post Surgical Patient
Patients undergoing Bariatric Surgery at the University of California Davis Medical Center will be divided into two groups, one receiving Standard of Care pain control medications vs the second group which will receive…
- Conditions
- Obesity, Morbid, Surgery, Bariatric Surgery Candidate
- Trial name
- NCT04240626
- Testing
- Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Postoperative Nausea and Vomiting
Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy
The goal of this superiority randomized controlled trial (RCT) is to learn if one dual-drug arm increases patient comfort (time to needing rescue medication for nausea/vomiting) more effectively than the other in adults with…
- Trial name
- NCT07638527
- Testing
- ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg
- Where
- Pakistan
- Volunteers
- 264 people
- Sponsor
- Faisalabad Medical University
Preeclampsia, Spinal Anesthesia-Induced Hypotension
Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia
This study compares the efficacy and safety of intravenous dexamethasone versus intravenous ondansetron in preventing low blood pressure (hypotension) following spinal anesthesia in pregnant women with preeclampsia undergoing…
- Conditions
- Preeclampsia, Spinal Anesthesia-Induced Hypotension, Cesarean Section
- Trial name
- NCT07793760
- Testing
- Dexamethasone, Ondansetron
- Volunteers
- 110 people
- Sponsor
- Assiut University
Small Cell Lung Cancer, Extra-Pulmonary Small Cell Carcinomas
PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers
Background: Drugs known as poly-adenosine diphosphate ribose polymerase (PARP) inhibitors are known to help stop tumor growth in patients with breast, ovarian cancers and many other cancers including prostate and pancreatic…
- Trial name
- NCT04209595
- Testing
- PLX038, Rucaparib, Ondansetron
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Sleep Quality, Postoperative Behaviour
Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)
Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record.
- Conditions
- Postoperative Sleep Quality, Postoperative Behaviour, Postoperative Recovery in Children, Postoperative Nausea and Vomiting (PONV)
- Trial name
- SCORPION (NCT07777276)
- Testing
- Dexamethasone (IV), Ondansetron iv
- Where
- 3 sites in Australia, Brazil
- Volunteers
- 500 people
- Sponsor
- Telethon Kids Institute
Lung Cancer (Diagnosis)Chemotherapy-Induced Nausea and Vomiting
Acupoint Application for Chemotherapy-Induced Nausea and Vomiting in Lung Cancer
This single-center, randomized, controlled study evaluates whether acupoint application added to standard 5-HT3 receptor antagonist anti-nausea medication improves control of chemotherapy-induced nausea and vomiting in adults…
- Trial name
- NCT07768124
- Testing
- 5-HT3 receptor antagonist (e.g., ondansetron), Acupoint application
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiu Huang