Clinical trials: Oxycodone, completed
Opioid-free Anesthesia, Anesthesia Depth Monitoring
Anesthesia Depth During Opioid Free Anesthesia
Opioid-free anesthesia is feasible and effective but still not common practice. Anesthesia depth monitoring is not investigated for use in anesthesia combining low dose infusions of several drugs with different sedative patterns…
- Trial name
- NCT06227143
- Testing
- Anesthesia depth monitoring
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Halland
Pain
Oxycodone-naloxone in Relieving Opioid-related Constipation
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects…
- Trial name
- NCT00412152
- Testing
- Oxycodone nalaxone prolonged release tablets (OXN)
- Sponsor
- Mundipharma Research GmbH & Co KG
Intubation Complication, Blood Pressure
Optimal Dose of Intravenous Oxycodone for Endotracheal Intubation
Intravenous form of oxycodone is recently used for the adjunct of anesthetic agents to avoid adverse effects of the stimulation of endotracheal intubation. The potency ratio of oxycodone to fentanyl is not absolutely defined.
- Trial name
- NCT02484352
- Testing
- saline, 0.05 mg/kg of oxycodone, 0.1 mg/kg of oxycodone
- Where
- South Korea
- Volunteers
- 95 people
- Sponsor
- Yong-Hee Park
Abortion Second Trimester
Overnight Pain Treatment Investigating Opioids vs. Nonopioids
The purpose of this study is to compare maximum pain scores between patients seeking induced abortion and requiring cervical preparation with osmotic dilators.
- Trial name
- OPTION (NCT03545893)
- Testing
- Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
Breast Cancer, Pain, Acute
ESP in Breast Surgery Due to Cancer
Patients scheduled for breast surgery due to cancer. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Conditions
- Breast Cancer, Pain, Acute, Anesthesia, Local
- Trial name
- NCT04726878
- Testing
- Erector spinae plane block, General anesthesia, Patient-controlled analgesia
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Lublin
Critical Illness
Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients
Systematic evaluation of pain, agitation and delirium in ICU-patients is recommended and deep sedation should be avoided. Sedation is still monitored with clinical assessments, like RASS.
- Trial name
- NCT03250481
- Testing
- Propofol
- Where
- Finland
- Volunteers
- 32 people
- Sponsor
- Helsinki University Central Hospital
Pain, Fracture, Sprain
Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Assess whether transbuccal fentanyl provides more rapid relief of orthopedic pain, than does the comparator Percocet
- Trial name
- FAIRTOP (NCT00685295)
- Testing
- Fentanyl, Lansoprazole, Oxycodone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Healthy
Healthy Volunteers Study to Estimate the Effects of Food on the Bioavailability of Oxycodone and Naltrexone/6- Β -Naltrexol From a Extended Release Formulation of Oxycodone With Sequestered Naltrexone
The purpose of this study is to estimate the effects of food and of sprinkling ALO-02 pellets on applesauce on the bioavailability of oxycodone and naltrexone/6- beta-naltrexol from an extended release pellets-in-capsule…
- Trial name
- NCT01456507
- Testing
- ALO-02 (Oxycodone Naltrexone)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused.
- Trial name
- NCT01746901
- Testing
- intact ALO-02 60 mg/7.2 mg, crushed ALO-02 60 mg/7.2 mg, crushed oxycodone IR 60 mg
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Pain
OTR Tablet 10 mg Fasted-state Bioequivalence Study
This is an open-label, single Dose, randomised, cross-over study to confirm the bioequivalence (BE) of OTR tablet 10 mg and OXYCONTIN tablet 10 mg in a fasted state in Chinese subjects with chronic pain
- Trial name
- NCT03403504
- Testing
- Oxycodone Tamper Resistant, OXYCONTIN®
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Pain, Abuse, Drug
Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-liability effects of a sub-threshold dose of a commonly used analgesic.
- Trial name
- NCT03679949
- Testing
- Oxycodone, Cannabis (THC:CBD = ~ 1:0), Cannabis (THC:CBD = ~ 0:1)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Lung Cancer, Postoperative Pain
Paravertebral Block Versus Thoracic Epidural Analgesia
Thoracic epidural analgesia (TEA) is the basic method of analgesia in patients undergoing pulmonary lobectomy. TEA is considered to be a safe and thoroughly investigated method of pain relief that rarely causes serious…
- Trial name
- NCT04025606
- Testing
- Thoracic epidural, Paravertebral block
- Where
- Norway
- Volunteers
- 94 people
- Sponsor
- St. Olavs Hospital
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Nausea
Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery
The study aims to compare the incidence of side effects caused by Oxycodone and Hydromorphone.
- Trial name
- NCT02295124
- Testing
- Oxycodone, Hydromorphone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Advanced Solid Cancers
Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain
For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons.
- Trial name
- NCT00478101
- Testing
- oxycodone fentanyl
- Volunteers
- 2,006 people
- Sponsor
- Gachon University Gil Medical Center
Post Operative Pain
An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.
The purpose of this study is to compare the analgesic efficacy of Xartemis 15mg/650mg by mouth every 12 hours for the management of acute moderate to severe post operative pain to generic Oxycodone/APAP(acetaminophen) (Percocet)…
- Trial name
- NCT02101476
- Testing
- Percocet, Xartemis
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Lotus Clinical Research, LLC
Pituitary Tumor, Pain
Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors
A randomized, double-blind, placebo-controlled intervention trial involving 100 treated subjects undergoing endonasal trans-sphenoidal (ENTS) resection of pituitary lesion.
- Trial name
- NCT02351700
- Testing
- IV Caldolor
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Perioperative Chest Pain
Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery
The post-thoracotomy pain (PTP) has been defined as persistent or recurrent pain that lasts for at least 2 month after thoracotomy and is associated with surgical incision or its intercostal nerve cutaneous distribution.
- Trial name
- NCT03120351
- Testing
- Lidoderm 5 % Topical Patch
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Hormones, Anesthesia, Conduction
The Impact of Regional Anaesthesia on Hormone Levels in Thoracic Surgery.
Basic aspects of thoracic anaesthesia are general anesthesia often combined with regional anesthesia, intubation with double lumen tube and separation of lung ventilation.
- Conditions
- Hormones, Anesthesia, Conduction, Thoracic Surgical Procedure
- Trial name
- NCT04414488
- Testing
- Thoracic paravertebral block (ThPVB)
- Where
- Poland
- Volunteers
- 119 people
- Sponsor
- Medical University of Silesia
Healthy, Opioid Use
Buprenorphine-Fentanyl Interaction Study
An increase in overdose deaths has been attributed to widespread access to fentanyl and carfentanyl. The study is designed to determine if buprenorphine can change the respiratory depression response to intravenous (IV) fentanyl.
- Trial name
- NCT03747341
- Testing
- Buprenorphine Injectable Solution - Part A, Fentanyl - Part A, Ondansetron - Parts A + B
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.