Clinical trials: Oxycodone
Pain Management
Opioid-Free Orthopaedic Surgery
To compare the safety and effectiveness of two pain control pathways following routine orthopaedic surgical procedures (single level or two-level ACDF/ACDA, 1st CMC arthroplasty, Hallux Valgus/Rigidus corrections, diagnostic knee…
- Trial name
- CORE (NCT04176783)
- Testing
- Opioids, Opioid-Free
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Cancer, Pain
Study Evaluating Safety and Tolerability of Oxycodone in Patients With Moderate to Severe Cancer Pain
This study is to evaluate the safety and tolerability of oxycodone control-released (CR) and/or immediate-released (IR) use in patients with moderate to severe cancer pain in a 3-months period in Taiwan.
- Trial name
- STOP Pain (NCT03176121)
- Testing
- Oxycodone
- Where
- 10 sites in Taiwan
- Volunteers
- 73 people
- Sponsor
- Taiwan Mundipharma Pharmaceuticals Ltd.
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Low Back Pain
Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain
This randomized, single-blind, parallel-group study will investigate the efficacy and the tolerability of a combination treatment of etoricoxib (30 mg/day) plus controlled-release oxycodone (10 mg/day) compared with a titrated…
- Trial name
- NCT01344720
- Testing
- etoricoxib, oxycodone
- Where
- 5 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Sanitaria Locale 4, Teramo
Arthroplasty
A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety
The purpose of this study is to test in patients who have had hip replacement surgery the effectiveness (level of pain control) and the safety of 3 different dose levels of CG5503 compared with placebo and with 10-mg oxycodone…
- Trial name
- NCT00364533
- Testing
- Tapentadol IR (CG5503), Oxycodone HCL IR
- Where
- 77 sites in United States, Belgium and 6 more
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Post-operative Pain
Prospective Pain Study Comparing Different Treatments After Hand Surgery
The purpose of the study is to evaluate the efficacy of three different types of pain medication (Oxycodone - an opioid, Ibuprofen - a non-steroidal anti-inflammatory, and Acetaminophen - a non-opioid analgesic) in the management…
- Trial name
- NCT03597308
- Testing
- 5mg of Oxycodone every 6 hours as needed for pain, 600mg of Ibuprofen every 6 hours as needed for pain, 500mg of Acetaminophen every 6 hours as needed for pain
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Rothman Institute Orthopaedics
Disc Herniation, Lumbosacral Radiculopathy
CT Guided Injection for Low Back Radiculopathy: A Randomized Clinical Trial
Herniated disc sometimes cause back pain radiating down to a leg. This pain can be so severe that it is functionally disabling. The purpose of this randomized clinical trial is to determine if corticosteroid medication, delivered…
- Trial name
- NCT01267825
- Testing
- CT-guided corticosteroid+ bupivicaine, Standard medical care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused when they are crushed and snorted.
- Trial name
- NCT01775189
- Testing
- crushed ALO-02 30 mg/3.6 mg, crushed oxycodone IR 30 mg
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Open-label, Single-dose Study to Investigate The Pharmacokinetics Between a GL2907 XL and Oxycontin CR Tab. 10mg in Healthy Male Volunteers
The purpose of this clinical trial is to compare the pharmacokinetic characteristics of GL2907 XL 20mg tablet and Oxycontin CR 10mg tablet. GL2907 XL 20mg tablet is controlled released formulation which is made by GL Pharm Tech.
- Trial name
- GL2907-101 (NCT01568450)
- Testing
- Oxycodone
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Post Tonsillectomy Pain
A Comparative Study With Parenteral Oxycodone, Morphine and Dexamethasone in Postoperative Pain in Paediatric Patients
The aim of this randomized, double-blind study is to compare parenteral pre-emptive oxycodone, morphine and dexamethasone with placebo in the treatment of postoperative pain in paediatric patients 4 to 12 years of age.
- Trial name
- DOM (NCT00733083)
- Testing
- 0,1 mg/kg of oxycodone, Morphine 0,1 mg/kg, Dexamethasone 0,5 mg/kg
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Turku
Spinal Disorder
Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery
The purpose of this research is to compare two outpatient pain management strategies in patients undergoing spinal surgeries such as microdiscectomies, foraminotomies, and spinal decompressions.
- Trial name
- NCT05965492
- Testing
- Acetaminophen, Celebrex, Gabapentin
- Sponsor
- University of Miami
Diabetic Neuropathy, Painful, Diabetic Polyneuropathy
A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the safety profile of orally administered tapentadol ER dosages of 100 to 250 mg twice daily in patients with chronic, painful diabetic peripheral neuropathy (DPN) over long-term exposure…
- Trial name
- NCT01063868
- Testing
- Tapentadol extended release (ER), Oxycodone controlled release (CR)
- Where
- 23 sites in United States
- Volunteers
- 47 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Supracondylar Humerus Fracture
Post-operative Pain Management in Children With Supracondylar Humerus Fractures
There are two common and concurrently used strategies for pain management following surgical treatment of supracondylar humerus (elbow) fractures in children: opioids vs over the counter pain medications.
- Trial name
- NCT05640674
- Testing
- Ibuprofen, Hydrocodone/acetaminophen, Acetaminophen
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Baylor College of Medicine
Narcotic Use
Nonopioid Analgesia After Labral Surgery
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of rotator cuff repair: a treatment group given a…
- Trial name
- NCT03825809
- Testing
- Celecoxib, Hydrocodone-Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Postoperative Pain, Opioid Induced Constipation
A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy
Objectives: Primary objective: To demonstrate that the treatment with OXN PR tablets up to 72 hrs after surgery is superior to the treatment with OxyPR with regards to constipation in subjects with postoperative pain after…
- Trial name
- NCT01109511
- Testing
- naloxone, oxycodone
- Where
- Norway
- Volunteers
- 85 people
- Sponsor
- Ullevaal University Hospital
Pain, Nausea
A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)
The objectives of this study are to compare the occurrence and severity of opioid-induced nausea and vomiting (OINV) associated with CL-108 to Norco®, and to demonstrate the efficacy of CL-108 when compared to placebo for the…
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT02462811
- Testing
- CL-108 (hydrocodone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg), Norco (hyrdocodone 7,5 mg, acetaminophen 325 mg)
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Joseph Hazelton
Malignant Neoplasms of Female Genital Organs, Gynecologic Cancer
Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway
Bupivacaine is a drug that is traditionally given as an injection to numb surgical sites. Liposomes are molecules that are similar to fats.
- Trial name
- NCT02740114
- Testing
- Bupivacaine, Liposomal Bupivacaine, Oxycodone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Subjects With Moderate to Severe, Chronic Nonmalignant Pain
A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain
The primary objective was to demonstrate the superiority of OXN over placebo over time from the initial dose of study medication to multiple pain events (inadequate analgesia) during the double blind phase.
- Trial name
- NCT01971632
- Testing
- Oxycodone & naloxone combination, prolonged release
- Volunteers
- 463 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Opioid Withdrawal, Opioid Use Disorder (OUD)
Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
This study is evaluating the Sparrow Link, a wearable device that delivers gentle electrical signals to nerves in the outer ear (a technique known as transcutaneous auricular neurostimulation, or tAN).
- Trial name
- NCT07079826
- Testing
- Sparrow Link (Active tAN)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Payel Roy