Clinical trials: Oxytocin
Alcohol Use Disorder
Oxytocin and Stress Response in Alcohol Use Disorder
Individuals with alcohol use disorder (AUD) will complete one functional Magnetic Resonance Imaging (fMRI) scanning visit. Prior to the scan, individuals will receive a nasal spray of either 24 international units (IU) of…
- Trial name
- NCT03610633
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Healthy
Oral Oxytocin Modulation of Responses to Emotional Stimuli
The main aim of the study is to investigate whether orally administered oxytocin (24IU) can modulate neural and behavioral responses to positive and negative valence stimuli during basal (emotional scenes) and higher order…
- Trial name
- NCT04320706
- Testing
- Oral Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Pain Inhibition and Facilitation in Post Partum Women
Endogenous Pain Facilitation and Inhibition in Postpartum Women
This study seeks to further understand these three observations - (1) that the time period surrounding childbirth accelerates recovery from pain after injury (2) that this likely reflects dampened facilitating mechanisms and…
- Trial name
- NCT01843517
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Social Intelligence
Effect of Intranasal Neuropeptide on Emotion Perception in Trait Anxiety
The purpose of this study is to learn more about how emotional processing may be affected by a hormone called oxytocin. Oxytocin is a hormone that occurs naturally in the body, and may play an important role in the way that the…
- Trial name
- NCT01551303
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Participants
The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain
This study investigates how belief and expectation influence empathic pain-the pain we feel when observing others in distress. Healthy adult participants will be randomly assigned to one of three groups: no-treatment control…
- Trial name
- PoB-EP (NCT07367672)
- Testing
- Intranasal Oxytocin (OT) 24 IU
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy Women of Child Bearing Potential
Assessment of Pharmacokinetics and Bioavailability of Carbon-14 ([14C])-Labelled Oxytocin
The current study is designed as a phase I multiple dose study to evaluate the pharmacokinetics and bioavailability of [14C]-labelled oxytocin in healthy women.
- Trial name
- NCT02911480
- Testing
- Oxytocin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxytone Bioscience BV
Blood Loss, Surgical, Intrapartum Hemorrhage
Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section
The aim of this clinical trial is to test if carbetocin is as effective as oxytocin plus misoprostol in decreasing intraoperative blood loss in women undergoing planned cesarean section.
- Trial name
- NCT05664659
- Testing
- Oxytocin + misoprostol, Carbetocin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams Maternity Hospital
Autism Spectrum Disorders
Intranasal Oxytocin and Learning in Autism
: The objective of this study is to determine the tolerability and therapeutic potential of oxytocin in children and adolescents with Autism Spectrum Disorders (ASD) when paired with a computer game intervention that is designed…
- Trial name
- NCT02090829
- Testing
- Syntocinon (synthetic oxytocin)
- Where
- United States
- Sponsor
- University of Minnesota
PTSD
Prolonged Exposure and Oxytocin
Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder that may develop after direct or indirect exposure to traumatic events.
- Trial name
- NCT03238924
- Testing
- Oxytocin
- Volunteers
- 17 people
- Sponsor
- Medical University of South Carolina
Complications; Cesarean Section, Adverse Reaction to Oxytocin
Outcomes After the Implementation of a New Oxytocin Protocol
The proposed study is a prospective, randomized, active control, open label study. One hundred sixty subjects undergoing elective cesarean section will be randomly assigned to one of two groups (n = 80 per group): the oxytocin…
- Trial name
- NCT02722356
- Testing
- Oxytocin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- C.R.Darnall Army Medical Center
Healthy
Effects of Intranasal Oxytocin on Emotion Regulation
The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.
- Trial name
- NCT03055546
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
Oxytocin, Trauma Disclosure and Intrusions
Severe traumatic experiences such as falling victim to assault, torture, or rape have deleterious effects. Clinical manifestations include intrusions, avoidance behavior, and hyperarousal, which are associated, at a circuit…
- Trial name
- NCT03425929
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Healthy
The Influence of Intranasal Oxytocin on Communication
This study investigates whether oxytocin, a neuropeptide known for its role in social bonding, influences the outcomes of persuasive communications and several primary evolutionary goals.
- Trial name
- NCT02415920
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depression, Postpartum
Cerebral Synchronization Between Mothers and Their Newborns During Breastfeeding
Different reciprocal positions of mother and newborn during breastfeeding may be adopted. Other than the one derived from UNICEF guidelines, or standard position, an approach called biological nurturing has been recently…
- Trial name
- NCT05821569
- Testing
- Standard approach, Biological nurturing
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Burlo Garofolo
Positive Expectations
Positive Expectation Effects on Early Emotional Processing
Insights into the mechanisms of expectation effects in the emotional domain can be invaluable for the development of potential therapeutic interventions for mood disorders.
- Trial name
- NCT07615530
- Testing
- Saline Nasal Spray
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Preeclampsia
Postpartum Hemorrhage Prevention in Patients With Preeclampsia (PHP3 Study)
Evaluation of the efficacy of postpartum 24 hour oxytocin infusion to reduce blood loss in patients with pre-eclampsia (PE)
- Trial name
- PHP3 (NCT02221830)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Postpartum Depression
The Effect of Early Dyadic Psychotherapy for Mothers Suffering From PPD on Oxytocin Level and on Childrens' Emotional Development
Background: Postpartum depression follows approximately 10-15% of deliveries. Maternal functional disability, particularly in the relationship with the infant, a hallmark of PPD, causes impairment in the mother's ability to bond…
- Trial name
- NCT04138368
- Testing
- dyadic psychotherapeutic intervention, supportive intervention
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Postpartum Hemorrhage
Misoprostol for the Treatment of Postpartum Hemorrhage
The purpose of this study is to test whether misoprostol is as effective as oxytocin for treating primary postpartum hemorrhage (PPH) with uterine atony as the suspected cause in two circumstances: 1) where women have received…
- Trial name
- NCT00116350
- Testing
- Misoprostol, Oxytocin
- Where
- 6 sites in Burkina Faso, Ecuador and 3 more
- Volunteers
- 1,786 people
- Sponsor
- Gynuity Health Projects
DELAYED LABOUR
High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women
Obesity is one of the biggest public health problems of the 21st century as it increases the risk of many co-morbid medical conditions.
- Trial name
- NCT03604874
- Testing
- Oxytocin
- Where
- Egypt
- Volunteers
- 202 people
- Sponsor
- Assiut University
Schizophrenia
Pharmacological Approach to Improve the Outcome of Social Cognition Training
This study will evaluate whether oxytocin will facilitate the learning of social cognitive skills in schizophrenia patients who receive 12 sessions of Social Cognitive Skills Training (SCST).
- Trial name
- NCT01517360
- Testing
- Oxytocin, Social Cognitive Skills Training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Greater Los Angeles Healthcare System