Clinical trials: Paracetamol
Postoperative Pain
Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery
This clinical trial is a multiple-center, randomized, double-blind, placebo- and active-controlled parallel-group Phase II/III clinical trial, to evaluate the efficacy and safety of HL-1186 Tablets for Postoperative Analgesia in…
- Trial name
- NCT07709598
- Testing
- HL-1186, Oxycodone-Acetaminophen
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Pain
Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement
The purpose of this study is to compare the efficacy of ibuprofen, acetaminophen, chewing gum in reducing orthodontic pain. This study include 81 patients to be classified into 4 groups of 19 each: ibuprofen (400 mg)…
- Trial name
- PECI (NCT03568721)
- Testing
- Ibuprofen, Acetaminophen, Chewing gum
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Rio de Janeiro State University
Postoperative Pain, Postoperative Pain Management
Evaluating the Efficacy and Utility of the Automated Pupillometer in Pain Assessment and Opioid Administration Guidance During the Perioperative Period: A Randomized Controlled Trial
Effective intraoperative and postoperative pain management is critical for patient comfort and recovery, yet traditional methods for assessing pain under general anaesthesia are limited by their subjective nature and reliance on…
- Trial name
- NCT07614607
- Testing
- Opioid Analgesic, automated pupillometry
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Cognitive Function
Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time.
- Trial name
- NCT06004687
- Testing
- acetaminophen mannitol, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Affiliated Hospital of Nantong University
Neonatal Diabetes
Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes
Neonatal diabetes is diagnosed before 6 months of age and causes high blood glucose levels due to the pancreas not secreting insulin. Neonatal diabetes can be caused by a change in a DNA region called the KCNJ11 gene.
- Trial name
- FoND (NCT02921906)
- Testing
- High protein meal, High carbohydrate meal, Paracetamol
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Multiple Myeloma in Relapse
Study Comparing Continuous Versus Fixed Duration Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma
The incorporation of proteasome inhibitors and immunomodulatory drugs into the standard of care has improved the outcome for patients with multiple myeloma (MM) over the past 10 years.
- Trial name
- CONFIRM (NCT03836014)
- Testing
- Daratumumab/Lenalidomide/Dexamethasone for 24 months, Daratumumab/Lenalidomide/Dexamethasone until progression
- Where
- France
- Volunteers
- 436 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tonsillectomy, Adenoidectomy
Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy
Tonsillectomy (the surgical removal of the tonsils) is a commonly performed surgery in children. One risk of tonsillectomy is postoperative bleeding, and this can be more dangerous in children because their blood volume is lower…
- Trial name
- NCT01605903
- Testing
- Ibuprofen, Acetaminophen
- Where
- 5 sites in United States
- Volunteers
- 741 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Severe Viral Pneumonia(Not Include COVID-19)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Uterine Blood Mesenchymal Stem Cells Injection for the Treatment of Severe Pneumonia Caused by Viruses
This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of Menstrual blood-derived Mesenchymal Stem Cells (SC01009) injection for the treatment of severe…
- Trial name
- NCT06693362
- Testing
- Drug therapy, Standard Treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Pain, Acute, Opioid Use, Unspecified
EMR Defaults to Nudge Opioid Prescribing
The investigators conducted a prospective, block-randomized study to determine whether and to what extent changes in the default settings in the electronic medical record (EMR) affect opioid prescriptions for patients discharged…
- Trial name
- NCT04155229
- Testing
- Default settings for opioid prescriptions (acetaminophen/hydrocodone, oxycodone, acetaminophen/oxycodone)
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Myofascial Pain
Radial Shock Wave and Acupuncture for Myofascial Pain
Myofascial pain syndrome is common in Rehabilitation clinic. The pain occurs asymmetrically in isolated or regional muscles, and is associated with acute muscle strain or chronic muscle overuse.
- Trial name
- NCT02024451
- Testing
- Radial shock wave, Acupuncture
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Morbid Obesity
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
The purpose of this study is to evaluate pharmacokinetics of paracetamol, amoxicillin and talinolol in morbid adipose subjects before as well as shortly after and about one year after proximal Roux-en-Y Gastric Bypass (RYGB) and…
- Trial name
- NCT02514941
- Testing
- paracetamol, amoxicillin, talinolol
- Where
- 2 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University Medicine Greifswald
Obesity, Childhood
Acetaminophen Dosing in Obese Adolescents
Although there are numerous studies investigating the pharmacokinetic properties of intravenous acetaminophen in infants and children with normal weight, there are none in the obese pediatric patient .
- Trial name
- NCT03192566
- Testing
- Tylenol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Radius Fracture Distal
Immobilization Without Reduction vs. Reduction Under General Anesthesia in Metaphyseal Fractures of the Distal Radius
Distal radius metaphyseal fractures are the most frequent in the pediatric population. The current treatment for angulated or shortened fractures is effective.
- Trial name
- NCT05008029
- Testing
- In situ immobilization, Reduction under general anesthesia
- Where
- Colombia
- Volunteers
- 59 people
- Sponsor
- Instituto de Ortopedia Infantil Roosevelt
Post Operative Pain, Acute, Post-Op Complication
Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery
This study aims to figure out how small-bore pigtail catheter or large-bore chest tube for postoperative drainage impact on analgesic efficacy and actually enhance recovery postoperatively.
- Conditions
- Post Operative Pain, Acute, Post-Op Complication, Opioid Use, Unspecified, ERAS
- Trial name
- NCT06050551
- Testing
- uniportal VATS
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Post Operative Pain
Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy
This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy.
- Trial name
- NCT04360135
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Radical Prostatectomy, Postoperative Pain
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
Prostate cancer is the commonest cancer form in men in Northern Europe. Management of the cancer often includes surgical removal of the primary tumor.
- Trial name
- RAPID (NCT03639389)
- Testing
- Bupivacaine, Analgesics
- Where
- 2 sites in Sweden
- Volunteers
- 211 people
- Sponsor
- Karolinska Institutet
Premature Birth
Population PK/PD of Off Label Drugs in Premature Neonates
This study will provide information on the pharmacokinetics, safety and effectiveness of off--label drugs used in critically ill premature infants: doxapram, fentanyl, midazolam, paracetamol, phenobarbital, sildenafil…
- Trial name
- DINO (NCT02421068)
- Where
- 4 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Sinno H.P. Simons
SARS-CoV-2 Infection (COVID-19)
PREEMPTIVE THERAPY WITH COLCHICINE IN PATIENTS OLDER THAN 60 YEARS WITH HIGH RISK OF SEVERE PNEUMONIAE DUE TO CORONAVIRUS
This is a phase 3 clinical trial, randomized, single-center, opened, controlled, to evaluate efficacy and safety of early administration of colchicines in patients older than 60 years, with high risk of pulmonary complications…
- Trial name
- COLCHI-COVID (NCT04416334)
- Testing
- Colchicine plus symptomatic treatment (paracetamol), Symptomatic treatment (paracetamol or best symptomatic treatment based on doctor recommendations)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Peritonsillar Abscess
The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess
The purpose of this study is to find if adding oral pain relievers as DYPIRON and TRAMADOL in addition to the local anesthesia injection, can help reducing the pain intensity in patients who diagnosed as Suffering from…
- Trial name
- pta (NCT01227200)
- Testing
- dypiron, tramadol
- Where
- 2 sites in Israel
- Volunteers
- 32 people
- Sponsor
- HaEmek Medical Center, Israel
Pilates Exercises, Nonspecific
Pilates Exercises on Nonspecific Low Back Pain in Postnatal Women
This study aims to investigate the effects of Pilates for postnatal women with Non-specific low back pain (NSLBP).
- Conditions
- Pilates Exercises, Nonspecific, Low Back Pain, Postnatal Women
- Trial name
- NCT07359144
- Testing
- Pilates program + Home exercise program, Home exercise program
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Kafrelsheikh University
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