Clinical trials: Paracetamol
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesics efficacy of paracetamol 1000mg vs 500mg . The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01082081
- Testing
- Paracetamol 1000 mg, Paracetamol 500 mg
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Post-operative Pain, Sinus Surgery
Postoperative Pain Control in Septum and Sinus Surgery
This study will evaluate if the use of acetaminophen round the clock (scheduled doses) will lead to less opiate use in the first week post-operative (after surgery) in sinus/septum surgery patients.
- Trial name
- NCT04149964
- Testing
- Acetaminophen 325 mg Oral Tablet, Acetaminophen 650 mg Oral Tablet, OxyCODONE 5 mg Oral Tablet
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Corewell Health East
Anesthesia, Myomectomy
Improved Recovery Using Multimodal Peri-operative Analgesia in Minimally Invasive Myomectomy
The purpose of this study is to evaluate a multimodal analgesic protocol used in minimally invasive surgery for myomectomies (laparoscopic myomectomy (LM) and laparoscopically assisted myomectomy (LAM)).
- Trial name
- NCT00978601
- Testing
- Multimodal analgesic protocol during minimally invasive myomectomy
- Where
- Greece
- Volunteers
- 95 people
- Sponsor
- Iakentro Fertility Centre
Metabolism
Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism
This is an open-label, fixed sequence study of the effect of probiotics supplementation on drug, vitamin, and hormone metabolism.
- Trial name
- NCT04281407
- Testing
- Visbiome
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Washington
Renal Colic
Comparative Efficacy of IV Dexamethasone vs. Nebulized Terbutaline for Renal Colic Pain in the ED
Adult patients (18-55 years of age) with clinical diagnosis of acute renal colic (sudden sharp colic flank pain with or without radiation to genitalia or groin and with or without urinary symptoms) who had pain score of 5 or more…
- Trial name
- NCT06980727
- Testing
- Terbutaline 2.5 mg, Dexamethasone
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Cytoreductive Surgery, Hyperthermic Intra-peritoneal Chemotherapy
Quadratus Lumborum Block After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy
This study aims to assess whether transmusculr quadratus lomborum block (QL block) can reduce postoperative pain after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC).
- Conditions
- Cytoreductive Surgery, Hyperthermic Intra-peritoneal Chemotherapy, Peritoneal Cancer
- Trial name
- NCT05597683
- Testing
- Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Gangnam Severance Hospital
Leiomyoma, Pelvic Organ Prolapse
The Influence of TAP Block in the Control of Postoperative Pain After Laparotomy for Gynecological Procedures
This study evaluates the influence of the transversus abdominis plane block on the intensity of postoperative pain and the concentration of proinflammatory and pain factors after hysterectomy by laparotomy.
- Conditions
- Leiomyoma, Pelvic Organ Prolapse, Abnormal Uterine Bleeding, Chronic Pain
- Trial name
- TAP (NCT04172272)
- Testing
- Systemic multimodal analgesia administered intravenously, Transversus abdominis plane block (TAP block), Combined transversus abdominis plane block (TAP block) with systemic multimodal analgesia administered intravenously
- Where
- 2 sites in Croatia
- Volunteers
- 75 people
- Sponsor
- General Hospital Pula
Pain, Postoperative, Obstructive Sleep Apnea-hypopnea Syndrome
Postoperative Pain Management on Uvulopalatopharyngoplasty Patients
This is a randomized controlled study, aimed to investigate the effects of dinalbuphine sebacate (DS) on patients having uvulopalatopharyngoplasty (UPPP). DS is a prodrug of nalbuphine, a mixed agonist-antagonist opioid.
- Conditions
- Pain, Postoperative, Obstructive Sleep Apnea-hypopnea Syndrome, Pain, Acute
- Trial name
- NCT05825495
- Testing
- Dinalbuphine sebacate, Routine practice
- Volunteers
- 78 people
- Sponsor
- Li-Jen Hsin
Pain Management
Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department
In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine.
- Trial name
- ADAMOPA (NCT04148495)
- Testing
- acetaminophen IV
- Where
- 11 sites in France
- Volunteers
- 415 people
- Sponsor
- Nantes University Hospital
Idiopathic Pulmonary Fibrosis, Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are sudden and severe worsening episodes that can be life-threatening. Currently, no treatment has been proven to clearly improve outcomes during these events.
- Trial name
- MERCURION-IPF (NCT07299695)
- Testing
- Intravenous immunoglobulin (IVIG), Usual treatment
- Where
- Greece
- Volunteers
- 196 people
- Sponsor
- Argyrios Tzouvelekis
Pain, Breast Diseases
T3AI-Pain After Breast Surgery
Current standard of care for post-operative analgesia after breast surgery in CDHA is Tylenol #3® (300 mg acetaminophen, 30 mg codeine, 15 mg caffeine per tablet).
- Trial name
- T3AI (NCT00299039)
- Testing
- acetaminophen plus codeine, acetaminophen plus ibuprofen
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Nova Scotia Health Authority
Delirium, Postoperative, Delirium in Old Age
The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium
Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery.
- Trial name
- SCOPE (NCT06721819)
- Testing
- Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center
Analgesia
Opioid Free Anesthesia for Laparoscopic Cholecystectomy
The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure.
- Trial name
- NCT06202664
- Testing
- Erector Spinae Block, Opioid Analgesic
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Appendectomy, Laparoscopy
TAP Block or Wound Infiltration for Laparoscopic Pediatric Appendectomy: a Pilot Study
Effectiveness of the TAP block compared to wound infiltration in controlling pain after laparoscopic appendectomy in children
- Conditions
- Appendectomy, Laparoscopy, Anesthesia, Conduction, Child, Preschool
- Trial name
- NCT04294537
- Testing
- TAP Block, LIA local infiltration, General anesthesia
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Analgesics, Opioid
Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass
Opioid free anesthesia is a recent anesthesia technique with the aim to avoid peroperative use of morphinics to allow a diminution of secondary morphinics effects in the postoperative period.
- Trial name
- NCT05004519
- Testing
- Dexmedetomidine Injection [Precedex], Remifentanil
- Where
- Belgium
- Volunteers
- 183 people
- Sponsor
- matthieu clanet
Rib Fractures, Rib Trauma
PVB vs Ketamine/Lidocaine in Rib Fracture Patients
Rib fractures are a common admission to the trauma service. The mainstay of treatment is pain control to improve respiratory effort in order to offset the risk of pneumonia and mechanical ventilation.
- Conditions
- Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute
- Trial name
- NCT04413799
- Testing
- lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- George Washington University
Common Cold
Effect of Paracetamol on the Common Cold
The aim of this study is to subjectively assess symptoms in subjects suffering from the common cold following a single dose of paracetamol hot drink compared to paracetamol tablet
- Trial name
- NCT01277081
- Testing
- Paracetamol hot drink, Paracetamol tablets
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- GlaxoSmithKline
Shoulder Pain
Does Meloxicam Provide as Much Pain Relief as Opioids After Shoulder Surgery?
The opioid epidemic continues to be a major concern, with orthopedic surgeons being among the top prescribers of opioids. Studies evaluating these practices found that opioids are overprescribed, even for common procedures.
- Trial name
- NCT04725357
- Testing
- Meloxicam 15 mg, Preoperative Interscalene Nerve Block, arthroscopic labral repair
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Low Back Pain
Acupuncture in Acute Nonspecific Low Back Pain
Acute low back pain is a common disorder in general practice. Some general practitioners (GPs) treat acute low back pain (LBP) with acupuncture, despite lacking evidence of its effectiveness for this condition.
- Trial name
- Acuback (NCT01439412)
- Testing
- Acupuncture and standard treatment, Standard treatment in general practice
- Where
- Norway
- Volunteers
- 185 people
- Sponsor
- University of Oslo
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