Clinical trials: Paracetamol, completed
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Anesthesia
Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Several studies demonstrated the effectiveness of OFA in patients undergoing non-cardiac surgery. Preoperative use of Cox inhibitors, GABA analogues and acetaminophen have been shown to decrease use of opioids postoperatively .
- Trial name
- NCT04648540
- Testing
- Dexmedetomidine 0.5 mic/kg/h, Fentanyl 1 mic/kg/hr
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction
The Copenhagen Analgesic Study
Fundamental aspects of reproductive function are established in fetal life and there is a present increased awareness of the potential effects of fetal exposures on reproductive health of offspring.
- Trial name
- COPANA (NCT04369222)
- Testing
- Observational
- Where
- 2 sites in Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hip Surgery, Postoperative Pain Management
Comparison of Intermittent Bolus vs. Continuous Infusion PENG Block for Postoperative Pain in Hip Surgery
This retrospective study evaluates the effects of two different administration methods of the Pericapsular Nerve Group (PENG) Block on postoperative pain control, opioid consumption, and recovery in patients undergoing hip…
- Conditions
- Hip Surgery, Postoperative Pain Management, Pericapsular Nerve Group Block (PENG Block), Regional Anesthesia
- Trial name
- ICPENG (NCT06834243)
- Testing
- Intermittent Bolus PENG Block, Continuous Infusion PENG Block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Onur Baran
Recurrence of Febrile Seizure
Antipyretics for Preventing Recurrences of Febrile Seizures
We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic…
- Trial name
- NCT00568217
- Testing
- Diclofenac, Paracetamol, Ibuprofen
- Where
- Finland
- Volunteers
- 231 people
- Sponsor
- University of Oulu
Analgesia
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal…
- Trial name
- NCT03907176
- Testing
- HTX-011, Luer lock applicator, Ibuprofen
- Where
- 30 sites in United States
- Volunteers
- 209 people
- Sponsor
- Heron Therapeutics
Pain and Curettage
Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage
Patients frequently experience pain from moderate to severe during gynecologic procedures. This study is a prospective, randomized, placebo-controlled trial and aimed to investigate the analgesic efficacy of preoperative oral…
- Trial name
- NCT01993589
- Testing
- comparison of pain relievers during curattage, comparison of pain relievers
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Lumbar Spine Disc Herniation, Lumbar Radiculopathy
Surgery Versus Standardized Non-operative Care for the Treatment of Lumbar Disc Herniations: A Canadian Trial
The objective of this study is to determine if surgery is superior to non-operative care for sciatica caused by a lumbar disc herniation.
- Trial name
- NCT01335646
- Testing
- Lumbar Microdiscectomy, Physiotherapy, Epidural injections, Education, Pain Medications, Anti-inflammatories
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- The London Spine Centre
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pain, Postoperative, Postoperative Nausea and Vomiting
Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery
In this prospective trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to general anesthesia with opioids combined with a Pecs II block or to general…
- Trial name
- NCT02544282
- Testing
- Levobupivacaine, NaCl 0.9%, Sevoflurane
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- GZA Ziekenhuizen Campus Sint-Augustinus
Pain
Ultrasound Guided Bilateral Erector Spinae Plane Block in Caesarean Delivery
Erector Spinae plane block (ESPB) is a regional anesthesia technique described three years ago. Its use for many indications has been identified by case reports in the literature.
- Trial name
- NCT04118413
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cigli Regional Training Hospital
Osteoarthritis
Toward Better Outcomes in Osteoarthritis
This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in…
- Trial name
- NCT00000425
- Testing
- Nonsteroidal anti-inflammatory drugs (NSAIDs), Acetaminophen
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Stanford University
Fever
Ibuprofen, Acetaminophen and Dipyrone to Fever Control in Children
The purpose of this study was to compare the efficacy and tolerability of acetaminophen, dipyrone and ibuprofen to fever control in children.
- Trial name
- NCT01359020
- Testing
- ibuprofen, dipyrone, acetaminophen
- Where
- Brazil
- Volunteers
- 396 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
Fibromyalgia
Adding Neuromodulation Technique to Cognitive Behavior Therapy on Fibromyalgia in Postmenopausal Women
The goal of this clinical trial is to investigate the effect of adding transcutaneous electrical nerve stimulation to cognitive behavior therapy on fibromyalgia in postmenopausal women.
- Trial name
- NCT07533487
- Testing
- TENS, Cognitive behavior therapy, medical treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Analgesia, Congenital Heart Disease
Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery
The goal of this clinical trial is to compare pain management in neonates and infants under 3 years of age undergoing cardiac surgery with use of cardiopulmonary bypass.
- Conditions
- Analgesia, Congenital Heart Disease, Surgery
- Trial name
- PACS (NCT05853263)
- Testing
- paracetamol, Morphine
- Volunteers
- 208 people
- Sponsor
- Erasmus Medical Center
Healthy Subjects
A Pharmacokinetic Study Investigating the Rate and Extent of Paracetamol Absorption of Three Experimental Sustained Release Pediatric Suspensions
This proof of principle PK study will allow GSKCH to select the most favorable sustained release formulation among 3 prototypes to move to the next stage of drug development.
- Trial name
- NCT01476215
- Testing
- Paracetamol fast dissolution suspension, Paracetamol medium dissolution suspension, Paracetamol slow dissolution suspension
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Covid19
Colchicine in Moderate Symptomatic COVID-19 Patients
This is a prospective, double blind, randomized, placebo controlled clinical trial. The participants will be randomized into two groups (group A and group B). Patients of group-A are the treatment group.
- Trial name
- COLCOVIDBD (NCT04527562)
- Testing
- Colchicine
- Where
- Bangladesh
- Volunteers
- 299 people
- Sponsor
- Dhaka Medical College
Parkinson's Disease
Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers
Single-centre, open-label, randomised, two-way cross-over study consisting of 2 periods separated by a washout period of 14 days or more.
- Trial name
- NCT02305017
- Testing
- BIA 9-1067, Paracetamol
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Corneal Abrasions
Proparacaine vs Placebo for Corneal Injuries
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days.
- Trial name
- Dogma (NCT00620997)
- Testing
- Proparacaine drops 0.05%, saline drops
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Postoperative Pain, Postpartum Anxiety
Acupressure for Pain and Anxiety After Cesarean Section
The goal of this clinical trial is to evaluate whether acupressure combined with standard post-operative modern medical care can reduce pain and anxiety in postpartum women after cesarean delivery under spinal anesthesia.
- Conditions
- Postoperative Pain, Postpartum Anxiety, Acupressure
- Trial name
- NCT07805720
- Testing
- Acupressure, Standard care
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
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