Clinical trials: Paracetamol
Patent Ductus Arteriosus
Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA
The investigator's purpose is to study the population pharmacokinetics of paracatamol and ibuprofen in neonates with patent ductus arteriosus (PDA) and assess the feasibility of dosage individualization.
- Trial name
- NCT04397913
- Testing
- Paracetamol, Ibuprofen
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Obesity, Pain, Postoperative
Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
The opioid consumption has exploded in the western world, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could…
- Trial name
- OS-PCC (NCT03756961)
- Testing
- Dexmedetomidine, Person-centred care (PCC), Esketamine
- Where
- 2 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Göteborg University
Cholecystectomy, Pain, Postoperative
Nonopioid Analgesics and Cholecystectomy
The goal of this clinical trial is to evaluate the effect of the addition of nefopam to a multimodal analgesic regimen consisting of ketoprofen and paracetamol during sevoflurane- dexmedetomidine-based anesthesia on postoperative…
- Conditions
- Cholecystectomy, Pain, Postoperative, Opioid Use
- Trial name
- NCT04622813
- Testing
- nefopam, ketoprofen, paracetamol, saline infusion, ketoprofen, paracetamol
- Where
- Lebanon
- Volunteers
- 90 people
- Sponsor
- American University of Beirut Medical Center
Upper Respiratory Infections
Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Pseudoephedrine 30 mg Syrup in Patients Suffering a URTI
This is an open label, in-use study to assess the warming sensation, acceptability and local tolerability of paracetamol 500 mg + pseudoephedrine 30 mg syrup, given as a single dose in subjects suffering from symptoms of an upper…
- Trial name
- NCT01586962
- Testing
- IFF flavor 316 282, Paracetamol, Pseudoephedrine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Novartis
Hip Fractures, Pain, Acute
The Impact of Integrated Preoperative Fascia Iliaca Compartment Block in Elderly Hip Fracture
This prospective randomized controlled study is aimed to determine the advantages of post-admission fascia iliaca compartment block (FICB) in geriatric hip fracture surgery combination with multimodal analgesia compared with no…
- Conditions
- Hip Fractures, Pain, Acute, Hip Fracture Surgery, Delirium in Old Age
- Trial name
- NCT05857462
- Testing
- Post-admission FICB
- Where
- Thailand
- Volunteers
- 420 people
- Sponsor
- Mahidol University
Acetaminophen Exposure
APAP-CYS Protein Adduct Concentrations in Patients With Liver-Directed Therapy Intended to Treat Hepatic Tumors
The objective of this study is to provide preliminary data to describe serum acetaminophen-cysteine protein adduct (APAP-CYS) concentrations following therapeutic doses of acetaminophen in the setting of non-acetaminophen induced…
- Trial name
- NCT02911961
- Testing
- Acetaminophen
- Where
- United States
- Sponsor
- Denver Health and Hospital Authority
Sickle Cell Disease, Vaso-occlusive Crisis
Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis
Sickle cell disease (SCD) is a severe hemoglobinopathy, characterized by recurrent vaso-occlusive crises (VOC) causing intense pain and frequent hospitalizations in adult patients.
- Trial name
- PAMAVOC (NCT07826988)
- Testing
- Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2)
A multi-centre open-label two-arm randomised superiority clinical trial of two weeks of oral Azithromycin 500mg once daily versus usual care in adult patients presenting to secondary care with clinically-diagnosed COVID-19 but…
- Trial name
- ATOMIC2 (NCT04381962)
- Testing
- Azithromycin Capsule
- Where
- 5 sites in United Kingdom
- Volunteers
- 298 people
- Sponsor
- University of Oxford
Pain Score (VAS)
Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia
Post-dural puncture headache (PDPH) is a well-recognized and potentially serious complication of subarachnoid block. While advancements in spinal needle design have reduced its incidence in recent years, PDPH still affects a…
- Trial name
- NCT06607861
- Testing
- saline group, dexmedetomidine group, lidocaine group
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Minia University
Anesthesia
Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients.
This study is a double blind randomized controlled trial. The investigators randomized ASA III and IV patients who underwent cholangiopancreatography. The investigators gave Propofol or Ketofol and compared the outcomes.
- Trial name
- NCT05473949
- Testing
- Profofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients, Ketofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients
- Volunteers
- 102 people
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Low Back Pain
A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol
Non inferiority, multicentric, double blind study whose the primary objective is to compare the effectiveness of two products in pain reduction.
- Trial name
- NCT01421433
- Testing
- Tandrilax, Dolamin Flex
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Farmoquimica S.A.
Post-operative Pain
Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery
Hypothesis: Postoperative pain will be equivalent in patients receiving preemptive oral acetaminophen as compared to patients receiving preemptive intravenous acetaminophen following minimally invasive benign gynecologic surgery.
- Trial name
- NCT03391284
- Testing
- acetominophen, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Scripps Health
Testicle Undescended, Pain, Postoperative
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
Surgical intervention to treat undescended testis is a very common pediatric surgical procedure, often performed using an inguinal incision or subscrotal incision approach.
- Trial name
- NCT03041935
- Testing
- Ilioinguinal/iliohypogastric nerve block, Caudal-epidural nerve block, Acetaminophen
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Leukemia
S0910 Epratuzumab, Cytarabine, and Clofarabine in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
RATIONALE: Monoclonal antibodies, such as epratuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00945815
- Testing
- epratuzumab, clofarabine, cytarabine
- Where
- 81 sites in United States
- Volunteers
- 35 people
- Sponsor
- SWOG Cancer Research Network
Patency of the Ductus Arteriosus, Acetaminophen
Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen
TREOCAPA is a Phase II/III European Multicentre study concerning the prophylactic treatment by Acetaminophen of extremely preterm infant during the first five days after birth.
- Conditions
- Patency of the Ductus Arteriosus, Acetaminophen, Extreme Prematurity
- Trial name
- TREOCAPA (NCT04459117)
- Testing
- Acetaminophen, NACL 0.9%
- Where
- 36 sites in Belgium, Denmark and 10 more
- Volunteers
- 804 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Renal Colic, Acute Renal Colic
Intravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations
The main objective of this study was to demonstrate the non-inferiority of intravenous paracetamol relative to intravenous ketoprofen when treating renal colic in an emergency ward.
- Trial name
- PIVKIV (NCT01685658)
- Testing
- Intravenous ketoprofen, Intravenous paracetamol
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Osteoarthritis of the Knee
Cupping in Osteoarthritis of the Knee
The purpose of this exploratory randomised trial is to study the effect of pulsatile cupping in osteoarthritis of the knee compared to waiting list control.
- Trial name
- NCT01057043
- Testing
- Pulsatile cupping
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Myeloma
A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma
The purpose of this study is to evaluate the safety, tolerability, and dose regimen of daratumumab when administered in combination with various treatment regimens for the treatment of multiple myeloma.
- Trial name
- NCT01998971
- Testing
- Daratumumab, Velcade, Pomalidomide
- Where
- 22 sites in United States, France and 1 more
- Volunteers
- 240 people
- Sponsor
- Janssen Research & Development, LLC
Hydrogen Peroxide Allergy
The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment.
Background: The administration of the intra-oral drugs was not capable of reducing this side effect, maybe the use of two analgesics may to present better analgesic effect to avoid the bleaching-induced tooth sensitivity (TS).
- Trial name
- NSAIDs (NCT03343392)
- Testing
- acetam/ketoro tromet group
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Uterine Cervical Cancer, Upper Aerodigestive Tract Neoplasms
Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)
The results of the study will permit to set up a standardized and validated procedure of pain management authorizing medical and paramedical staff of brachytherapy department to handle pain and in this way to improve the quality…
- Trial name
- KETOCOL (NCT02439034)
- Testing
- Paracetamol, Ketoprofen
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Oscar Lambret
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