Clinical trials: Paracetamol, completed
Post Operative Pain, Midline Sternotomy Incision
Percutaneous Electrical Nerve Stimulation (PENS) of the Auricle for Post Operative Pain Solution(POPS) - Cardiac Surgery
Percutaneous Electrical Nerve Stimulation (PENS) of the auricle for acute pain management post cardiac surgery
- Trial name
- POPS (NCT03750357)
- Testing
- Primary Relief v 2.0
- Where
- India
- Volunteers
- 60 people
- Sponsor
- DyAnsys, Inc.
Pain, Postoperative, Cardiac Surgery
Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)
The main objective is to compare the effectiveness of LocoRegional Anesthesia (LRA) (bilateral transverse thoracic block or bilateral parasternal block) in addition to standard management compared to standard management alone…
- Trial name
- PABLOS (NCT05345639)
- Testing
- LRA Loco-regional anesthesia, Standardized post-operative analgesia protocol
- Where
- France
- Volunteers
- 254 people
- Sponsor
- University Hospital, Angers
Postoperative Pain
A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to determine a maximum tolerated dose of IV PGB and to evaluate the safety, tolerability, and PK of an admixture of IV PGB…
- Trial name
- NCT04265456
- Testing
- Pregabalin 100mg, Acetaminophen 1300mg
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Pain, Low Back 'Spine Fusion' Surgery
'Acupuncture Therapy' for Pain and Function Recovery in Spine Surgery Patients
Acupuncture has been studied in the perioperative setting and shown to reduce pain, anxiety, nausea and vomiting. Studies have been conducted in orthopedic surgery patients, but not spine patients.
- Trial name
- Acuspine (NCT01304979)
- Testing
- Acupuncture therapies, Control
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Beth Israel Medical Center
Pain, Postoperative
Analgesic Efficacy, Safety and Tolerability of Two Paracetamol-Containing Solutions in Post-Surgical Hip Replacement Pain
The aim of the study is to evaluate the therapeutic efficacy, safety and local tolerability of two different paracetamol-containing solutions in postoperative total hip replacement.
- Trial name
- NCT00508495
- Testing
- Paracetamol (acetaminophen), Paracetamol 1% solution, 0.9% sodium chloride solution
- Where
- 8 sites in Hungary
- Volunteers
- 148 people
- Sponsor
- Baxter Healthcare Corporation
Acute Pain
TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy
Laparoscopic and Robotic assisted hysterectomy is a surgical procedure that is a minimally invasive way in which to remove the uterus, which has less scarring and fewer complications.
- Trial name
- NCT02519023
- Testing
- Liposomal Bupivacaine, Bupivacaine, Ultrasound
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Minnesota
Pain
Trama-Code (Two Analgesics-comparative Study)
Double-blind randomized study to compare the efficacy of two analgesic drugs(Ixprim®, Dafalgan-Codeine®) in the emergency unit. The efficacy (relief of pain) would be assessed 2 hours after administration of one of the two drugs…
- Trial name
- Trama-Code (NCT01782846)
- Testing
- Ixprim®, Dafalgan-Codeine®
- Where
- France
- Volunteers
- 803 people
- Sponsor
- Hopital Foch
Healthy
A Study to Assess the Bioequivalence of a New ULTRACET Extended Release (ER) Tablet With Respect to a Marketed ULTRACET ER Tablet Under Fasted Condition
The purpose of this study is to evaluate the bioequivalence of a newly developed ULTRACET extended-release (ER) tablet of tramadol hydrochloride and acetaminophen, to the current marketed ULTRACET ER tablet, in healthy…
- Trial name
- NCT01778075
- Testing
- Tramadol HCl 75 mg/Acetaminophen 650 mg (Newly developed ULTRACET ER), Tramadol HCl 75 mg/Acetaminophen 650 mg (Marketed ULTRACET ER)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Janssen Korea, Ltd., Korea
Postcesarean Analgesia
Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia
The study will compare the analgesic efficacy of transversus abdominis plane block and wound infiltration in parturients undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02691572
- Testing
- Spinal anesthesia, Intrathecal bupivacaine, Intrathecal fentanyl
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Healthy
Clinical Bioequivalence Study on Two Paracetamol Tablet Formulations
The objective of the study is to compare the bioavailability of a generic product of paracetamol (immediate-release) with that of a reference product when administered to healthy volunteers under fasting condition.
- Trial name
- NCT03562780
- Testing
- Fortolin Tab 500mg, Panadol Caplet 500mg
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fortune Pharmacal Co., Ltd.
Proximal Femur Fracture
Postoperative Pain Relieve for Patients Undergoing Surgical Treatment of Femoral Fracture
The aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.
- Trial name
- NCT05920642
- Testing
- Intrathecal morphine administration, Parenteral administration of analgesics
- Where
- Czechia
- Volunteers
- 82 people
- Sponsor
- University Hospital Ostrava
Rib Fracture Multiple
Serratus Anterior Plane Block for Improving Pain and Respiratory Function in Patients With Multiple Rib Fractures
This is an observational study which will evaluate the efficacy of the serratus anterior plane block for treating pain and respiratory capacity in patients with multiple rib fractures.
- Trial name
- NCT04311827
- Testing
- Serratus Anterior Plane Block
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Stanford University
Inguinal Hernia Bilateral, Postoperative Pain
M-TAPA vs OSTAP for Postoperative Analgesia in Laparoscopic Inguinal Hernia
This randomized controlled trial aims to compare the postoperative analgesic efficacy of M-TAPA block and OSTAP block in patients undergoing laparoscopic inguinal hernia repair.
- Trial name
- NCT07522853
- Testing
- Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA), Oblique Subcostal Transversus Abdominis Plane Block (OSTAP), Standard Analgesia use (paracetamol, contramal)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Overweight or Obese
A Study of BGM0504 in Overweight or Obese Participants
The purpose of the study is to evaluate the influence of BGM0504 injection on gastric emptying and Pharmacokinetics of metformin and warfarin in overweight or obese participants
- Trial name
- NCT06920056
- Testing
- Paracetamol, Metformin Hydrochloride, Warfarin
- Where
- China
- Volunteers
- 28 people
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
COVID-19 Respiratory Infection, FLU
Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients
The primary objective of this study is to determine the safety and efficacy profile of the food supplement (KUNAMIN®) containing grape juice, seed, stem, and bark given to patients treated with the established treatment regimen…
- Conditions
- COVID-19 Respiratory Infection, FLU, Cold; Influenza, Bacterial Pneumonia
- Trial name
- NCT05417997
- Testing
- Kunamin®, Favipiravir, Enoxaparin
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- RAAS Nutritionals, LLC
Lumbar Surgery
Enhanced Recovery After Surgery in Orthopaedic Spine Surgery
This study aims to determine the impact and effect of enhanced recovery after surgery (ERAS) principles in the recovery and rehabilitation of patients following elective orthopaedic spine surgery with a specific emphasis on oral…
- Trial name
- ERAS (NCT04562610)
- Testing
- Intravenous Infusion group, All oral administration group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, Davis
Carcinoma, Non-Small-Cell Lung
KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) in combination with boserolimab (MK-5890), MK-4830, MK-0482 in participants with advanced squamous or non-squamous NSCLC that have been…
- Trial name
- NCT04165096
- Testing
- Pembrolizumab, Boserolimab, MK-4830
- Where
- 39 sites in United States, Hungary and 5 more
- Volunteers
- 128 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypertension, Pregnancy-Induced, Pre-eclampsia
The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy
To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).
- Trial name
- NCT02891174
- Testing
- Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
Postherpetic Neuralgia
Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia
Background: Acute herpes zoster causes severe neuropathic pain and may progress to postherpetic neuralgia (PHN). This study aims to evaluate ultrasound-guided thoracic paravertebral block with local anesthetic and steroid in…
- Trial name
- NCT07349680
- Testing
- Valacyclovir + Paracetamol (Acetaminophen) + Gabapentin (standard medical therapy), Ultrasound-guided thoracic paravertebral block (TPVB) with bupivacaine 0.25% + methylprednisolone 40 mg
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes After Total Pancreatectomy
Involvement of Dipeptidyl Peptidase-4 and Sodium-glucose Co-transporter-2 in Extrapancreatic Glucagon Secretion
Glucagon is a 29-amino acid peptide hormone of essential importance for glucose homeostasis. Hitherto glucagon has been believed to be secreted only from the pancreas, but recent studies show that glucagon is also secreted from…
- Trial name
- Px-Meal (NCT04061473)
- Testing
- Sitagliptin 100mg, Empagliflozin 25 MG
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
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