Clinical trials: Paracetamol, completed
Musculoskeletal Pain
Patient Education to Improve Pain Management in Older Adults With Acute Musculoskeletal Pain: A Pilot Randomized Trial
This is a three arm pilot randomized trial. Patients will be assigned to: 1. Usual care 2. Video education in the Emergency Department (ED) 3.
- Trial name
- BETTER_Pilot (NCT02438384)
- Testing
- Video, Phone follow-up
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain
Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment.
Aim to compare Incidence of flare-ups and apical healing after single-visit or two-visits treatment of teeth with necrotic pulp and apical periodontitis after a two-year control period.
- Trial name
- FlareUp (NCT02815189)
- Testing
- Ibuprofen for post operative pain, Acetaminophen 325 mg for Flare up
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Cleft Palate
Suprazygomatic Block in Cleft Palate Surgery in Children
Cleft palate (CP) is a common congenital malformation, with an incidence ranging from 0.1 to 1.1 per 1000 births depending on the population group (liau et al, 2010).
- Trial name
- NCT03412474
- Testing
- Bupivacaine, Dexmedetomidine, paracetamol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mucositis
Local Anesthetic Treatment of Oral Pain in Patients With Mucositis
Oral mucositis is a damage to the mucosa of the oral cavity and pharynx. It is a serious and painful adverse effect caused by the radio therapy and/or chemo therapy patients with head and neck cancer receive.
- Trial name
- NCT02252926
- Testing
- Bupivacaine, Standard treatment (lidocaine viscous solution, morphine, paracetamol, NSAID, gabapentin)
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Hvidovre University Hospital
Fear and Anxiety
The Effect of Virtual Reality on Pain, Anxiety, and Fear During Burn Dressing in Children
This research was conducted to determine the effect of VR on the pain, anxiety, and fear levels experienced by patients during burn dressing.
- Trial name
- NCT05032586
- Testing
- wearing virtual reality headsets
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ataturk University
COVID-19
A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2)
A multi-centre open-label two-arm randomised superiority clinical trial of two weeks of oral Azithromycin 500mg once daily versus usual care in adult patients presenting to secondary care with clinically-diagnosed COVID-19 but…
- Trial name
- ATOMIC2 (NCT04381962)
- Testing
- Azithromycin Capsule
- Where
- 5 sites in United Kingdom
- Volunteers
- 298 people
- Sponsor
- University of Oxford
Postoperative Nausea and Vomiting, Postoperative Pain
Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy
Laparoscopic abdominal surgery carries one of the highest risks of postoperative nausea and vomiting (PONV), and postoperative opioids given for pain are themselves emetogenic.
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Anesthesia, Anesthesia Spinal
- Trial name
- NCT07851870
- Testing
- Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis
- Where
- Indonesia
- Volunteers
- 63 people
- Sponsor
- Universitas Indonesia
Biliary Tract Diseases, Pancreatic Diseases
Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)
Self-administration of propofol and opioid mixture by the patient him- or herself (patient-controlled sedation, PCS) could be successful alternative to the anesthesiologists-managed deep sedation during endoscopic retrograde…
- Trial name
- NCT01350037
- Testing
- alfentanil, remifentanil
- Where
- Finland
- Volunteers
- 81 people
- Sponsor
- Helsinki University Central Hospital
Fabry's Disease
A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme
This Phase 4 study will evaluate the safety and tolerability of Fabrazyme at current approved dose with increases in the infusion rate and reduced infusion volume.
- Trial name
- SHORTEN (NCT06019728)
- Testing
- AGALSIDASE BETA (GZ419828), Acetaminophen, Diphenhydramine
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Sanofi
Obesity
Erector Spina Plane Block in Laparoscopic Sleeve Gastrectomy Surgery
The aim of the study is to evaluate the effect of erector spina plane (ESP) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery.
- Trial name
- NCT04039321
- Testing
- ESPB group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Antalya Training and Research Hospital
Pain
Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement
The purpose of this study is to compare the efficacy of ibuprofen, acetaminophen, chewing gum in reducing orthodontic pain. This study include 81 patients to be classified into 4 groups of 19 each: ibuprofen (400 mg)…
- Trial name
- PECI (NCT03568721)
- Testing
- Ibuprofen, Acetaminophen, Chewing gum
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Rio de Janeiro State University
Neonatal Diabetes
Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes
Neonatal diabetes is diagnosed before 6 months of age and causes high blood glucose levels due to the pancreas not secreting insulin. Neonatal diabetes can be caused by a change in a DNA region called the KCNJ11 gene.
- Trial name
- FoND (NCT02921906)
- Testing
- High protein meal, High carbohydrate meal, Paracetamol
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Tonsillectomy, Adenoidectomy
Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy
Tonsillectomy (the surgical removal of the tonsils) is a commonly performed surgery in children. One risk of tonsillectomy is postoperative bleeding, and this can be more dangerous in children because their blood volume is lower…
- Trial name
- NCT01605903
- Testing
- Ibuprofen, Acetaminophen
- Where
- 5 sites in United States
- Volunteers
- 741 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pain, Acute, Opioid Use, Unspecified
EMR Defaults to Nudge Opioid Prescribing
The investigators conducted a prospective, block-randomized study to determine whether and to what extent changes in the default settings in the electronic medical record (EMR) affect opioid prescriptions for patients discharged…
- Trial name
- NCT04155229
- Testing
- Default settings for opioid prescriptions (acetaminophen/hydrocodone, oxycodone, acetaminophen/oxycodone)
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Myofascial Pain
Radial Shock Wave and Acupuncture for Myofascial Pain
Myofascial pain syndrome is common in Rehabilitation clinic. The pain occurs asymmetrically in isolated or regional muscles, and is associated with acute muscle strain or chronic muscle overuse.
- Trial name
- NCT02024451
- Testing
- Radial shock wave, Acupuncture
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Morbid Obesity
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
The purpose of this study is to evaluate pharmacokinetics of paracetamol, amoxicillin and talinolol in morbid adipose subjects before as well as shortly after and about one year after proximal Roux-en-Y Gastric Bypass (RYGB) and…
- Trial name
- NCT02514941
- Testing
- paracetamol, amoxicillin, talinolol
- Where
- 2 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University Medicine Greifswald
Radical Prostatectomy, Postoperative Pain
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
Prostate cancer is the commonest cancer form in men in Northern Europe. Management of the cancer often includes surgical removal of the primary tumor.
- Trial name
- RAPID (NCT03639389)
- Testing
- Bupivacaine, Analgesics
- Where
- 2 sites in Sweden
- Volunteers
- 211 people
- Sponsor
- Karolinska Institutet
Premature Birth
Population PK/PD of Off Label Drugs in Premature Neonates
This study will provide information on the pharmacokinetics, safety and effectiveness of off--label drugs used in critically ill premature infants: doxapram, fentanyl, midazolam, paracetamol, phenobarbital, sildenafil…
- Trial name
- DINO (NCT02421068)
- Where
- 4 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Sinno H.P. Simons
SARS-CoV-2 Infection (COVID-19)
PREEMPTIVE THERAPY WITH COLCHICINE IN PATIENTS OLDER THAN 60 YEARS WITH HIGH RISK OF SEVERE PNEUMONIAE DUE TO CORONAVIRUS
This is a phase 3 clinical trial, randomized, single-center, opened, controlled, to evaluate efficacy and safety of early administration of colchicines in patients older than 60 years, with high risk of pulmonary complications…
- Trial name
- COLCHI-COVID (NCT04416334)
- Testing
- Colchicine plus symptomatic treatment (paracetamol), Symptomatic treatment (paracetamol or best symptomatic treatment based on doctor recommendations)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Pain and Discomfort, Orthodontic Appliance Complication
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
Patients with class I malocclusion who have mild to moderate crowding will be treated in this study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to orthodontic treatment will be assessed.
- Trial name
- NCT03400111
- Testing
- low-level laser therapy, Panadol-extra
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
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