Clinical trials: Paracetamol
Back Pain Lower Back
Improvement in Pain,Function and HRQoL ( Health Related Quality of Life) in Subacute Low Back Pain: A Controlled Clinical Trial of Exercise vs NSAIDs (Nonsteroidal Antiinflammatory)
Our clinical trial has the purpose to evaluate the effectiveness in reducing pain and improving function and quality of life during a 6-months follow-up of a therapeutic exercise program compared to pharmacological treatment with…
- Trial name
- DLSEA (NCT01374269)
- Testing
- Exercise program, NSAID (Nonsteroidal anti-inflammatory drugs)
- Where
- 2 sites in Colombia
- Volunteers
- 90 people
- Sponsor
- Grupo Rehabilitacion en Salud
Cerebral Hemorrhage, Cerebral Edema
Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study
The goal of this study is to preliminarily determine/estimate feasibility and whether frequent and early conivaptan use, at a dose currently determined to be safe (i.e., 40mg/day), is safe and well-tolerated in patients with…
- Conditions
- Cerebral Hemorrhage, Cerebral Edema, Intracerebral Hemorrhage, Stroke
- Trial name
- NCT03000283
- Testing
- Conivaptan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jesse Corry
Subarachnoid Hemorrhage, Stroke
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
This study compares the bioavailability of IV and PO acetaminophen in both blood and the cerebrospinal fluid (CSF) of patients following subarachnoid hemorrhage.
- Trial name
- aSAH (NCT02549716)
- Testing
- IV acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Acetaminophen Metabolism, Acetaminophen Poisoning
Effect on Acetaminophen Metabolism by Liquid Formulations
The purpose of this study is to determine whether excipients in the liquid formulation of acetaminophen prevent the formation of the toxic metabolites of acetaminophen.
- Conditions
- Acetaminophen Metabolism, Acetaminophen Poisoning, Drug Metabolism by Excipients
- Trial name
- NCT01246713
- Testing
- Acetaminophen liquid formulation, Acetaminophen solid formulation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Blood Cancer, Leukemia
Allogeneic Transplantation From Related Haploidentical Donors
The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+ selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative regimen of total lymphoid irradiation (TLI)…
- Conditions
- Blood Cancer, Leukemia, Graft Versus Host Disease, Malignancy
- Trial name
- NCT00185692
- Testing
- non-myeloablative hematopoietic cell transplantation, Anti-Thymocyte Globulin, Cyclosporine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
Dysmenorrhea
A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea
The purpose of this study is to compare the maximum single dose of Aleve® (two tablets, equivalent to 440 mg of naproxen sodium) to the maximum single dose of Tylenol Extra Strength (two caplets, equivalent to 1000 mg of…
- Trial name
- NCT03448536
- Testing
- Naproxen Sodium, (Aleve, BAY117031), Acetaminophen (Tylenol Extra Strength)
- Where
- 8 sites in United States
- Volunteers
- 201 people
- Sponsor
- Bayer
Adenotonsillitis, Tonsillitis
Analgesic Effect of IV Acetaminophen in Tonsillectomies
Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile…
- Trial name
- NCT01691690
- Testing
- Acetaminophen (paracetamol), Normal Saline Flush, Midazolam
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Hip Surgery, Post Operative Pain Control
Post Operative Pain Control After Pediatric Hip Surgery
Hip surgery in children is painful and the optimal modality for managing post-operative pain has not been established. This prospective randomized controlled trail compares lumbar plexus catheter (LPC), lumbar epidural catheter…
- Trial name
- NCT03435692
- Testing
- Lumbar Plexus Catheter, Lumbar Epidural Catheter, Patient Controlled Analgesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Temporomandibular Disorder
Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain
Temporomandibular disorders (TMDs) are one of the most common muco-skeletal disorders, seen in the dental clinics. Many factors work together to initiate or aggravate the condition, so it is a multifactorial disorder.
- Trial name
- NCT04066426
- Testing
- naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Yuzuncu Yil University
Mesothelioma
Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
Background: Mesothelioma is a type of cancer. It originates in cells that line human body cavities. Most people have advanced disease when they are diagnosed. Researchers want to see if a combination of drugs can help.
- Trial name
- NCT04840615
- Testing
- LMB-100, ipilimumab, Diphenhydramine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Musculoskeletal Pain
Patient Education to Improve Pain Management in Older Adults With Acute Musculoskeletal Pain: A Pilot Randomized Trial
This is a three arm pilot randomized trial. Patients will be assigned to: 1. Usual care 2. Video education in the Emergency Department (ED) 3.
- Trial name
- BETTER_Pilot (NCT02438384)
- Testing
- Video, Phone follow-up
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Morbid Obesity, Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia, Bariatric Surgery
- Trial name
- NCT07337135
- Testing
- Opioid-Based Anesthesia (Remifentanil-Based Protocol), Opioid-Free Anesthesia (Dexmedetomidine-Ketamine-Lidocaine Protocol)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Hospital dos Lusíadas
Supracondylar Humerus Fracture
Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management
This purpose of this study is to determine the efficacy of nonopioid versus opioid analgesic regimens following surgical fixation of Gartland Type III Supracondylar Humoral Fractures (SCHFs) to assist in the development of a…
- Trial name
- NCT06187584
- Testing
- Hydrocodone/acetaminophen, Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Mercy Hospital Kansas City
Prostate Cancer
Postoperative Pain Control for Prostatectomy
The researchers propose to investigate a relatively new anesthetic procedure, in order to maximize patient comfort and minimize the use of narcotics after a radical prostatectomy.
- Trial name
- TAP (NCT00913068)
- Testing
- Transverse Abdominal Plan (TAP), standard post op pain control
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis, Hip
Minimal Opioid Use After Total Hip Replacement (THR)
Total hip arthroplasty can be associated with significant postoperative pain. Side effects of pain management may impair participation in physical therapy and slow readiness for discharge from the hospital.
- Trial name
- NCT03090152
- Testing
- Periarticular injection (Deep injection), Periarticular injection (Superficial injection), Bupivacaine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Hospital for Special Surgery, New York
Drug Toxicity, Healthy
Aminotransferase Trends During Prolonged Acetaminophen Dosing
The objective of this study is to monitor liver function tests (blood levels of an indicator of liver function) of healthy people taking the maximum labeled daily dose of acetaminophen compared to people taking placebo for 16 to…
- Trial name
- NCT00743093
- Testing
- acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Pain, Fibromyalgia
An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
The purpose of this study is to evaluate the analgesic effect of combination of tramadol hydrochloride and acetaminophen in participants for treatment of fibromyalgia pain (chronic widespread pain and presence of tender points).
- Trial name
- NCT00766675
- Testing
- Tramadol hydrochloride, Acetaminophen
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Taiwan Ltd