Clinical trials: Pioglitazone, completed
Intracerebral Hemorrhage
Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease with less than 20% of survivors being independent at 6 months. There is currently no approved treatment for ICH which has been shown to improve outcomes.
- Trial name
- SHRINC (NCT00827892)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus, Type 2
Safety and Efficacy of Vildagliptin vs. Thiazolidinedione as add-on Therapy to Metformin in Patients With Type 2 Diabetes Not Controlled With Metformin Alone
This study is designed to evaluate, in a primary care setting, the safety and efficacy of vildaglipgtin as add on therapy to metformin relative to TZD added to metformin in patients with type 2 diabetes inadequately controlled by…
- Trial name
- NCT00396227
- Testing
- vildagliptin, thiazolidinedione (TZD)
- Where
- United States
- Volunteers
- 2,665 people
- Sponsor
- Novartis Pharmaceuticals
Adrenomyeloneuropathy, X-linked Adrenoleukodystrophy
Effect of Pioglitazone Administered to Patients With Adrenomyeloneuropathy
X-linked adrenoleukodystrophy is a rare, demyelinating and neurodegenerative disorder, due to loss of function of a fatty acid transporter, the peroxisomal ABCD1 protein.
- Trial name
- XAMNPIOP2011 (NCT03864523)
- Testing
- Pioglitazone
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Pujol, Aurora, M.D.
Metabolic Syndrome X, Prediabetic State
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation
The relationship between obesity and insulin resistance is known, however the mechanism(s) associating obesity with insulin resistance is not well understood.
- Trial name
- NCT00470262
- Testing
- Fenofibrate 145mg PO QD, Pioglitazone 45 mg PO QD
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes
Pioglitazone/Glimepiride (Sonias) Combination Tablets Special Drug Use Surveillance Survey in Patients With Type 2 Diabetes Mellitus Who Respond Poorly to Pioglitazone
The purpose of this study is to evaluate the safety and efficacy of long-term use of pioglitazone/glimepiride combination tablets (Sonias Combination Tablets LD) in patients with type 2 diabetes mellitus who respond poorly to…
- Trial name
- NCT02098746
- Testing
- Pioglitazone/glimepiride
- Volunteers
- 294 people
- Sponsor
- Takeda
Inflammation, Hypertension
Efficacy Study of Pioglitazone and Ramipril Combination Therapy in Treating Non-diabetic Hypertensive Patients.
The purpose of this study is to determine the effects of pioglitazone, once daily (QD), on low grade inflammation and vascular function in hypertensive patients.
- Trial name
- NCT00770497
- Testing
- Pioglitazone, Pioglitazone and ramipril, Ramipril
- Where
- 13 sites in Germany
- Volunteers
- 172 people
- Sponsor
- Takeda
Anaemia
Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers
This study will be a two-part with an open-label, single oral dose, two-way crossover study design. Part A and Part B of the study are independent and may be conducted in parallel.
- Trial name
- NCT02371603
- Testing
- GSK1278863 25 mg Tablet, Pioglitazone 15 mg Tablet, Rosuvastatin 10 mg Tablet
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes
Use of Continuous Glucose Monitoring Combined With Ambulatory Glucose Profiles to Characterize Glycemic Control
Obtain Continuous Glucose Monitoring (CGM) data from individuals taking exenatide LAR, sitagliptin, or pioglitazone. The CGM measurements collected will help determine the characteristics of glucose control prior to treatment and…
- Trial name
- NCT00806520
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- HealthPartners Institute
Type 2 Diabetes
Trial for People With Established Type 2 Diabetes During Ramadan
Dual therapy with metformin and Liraglutide is more effective at helping people with established Type 2 Diabetes Mellitus (T2DM) observing Ramadan achieve a triple composite endpoint of weight reduction and/or maintenance and…
- Trial name
- T4R (NCT02292290)
- Testing
- Liraglutide, Sulfonylurea or Pioglitazone, Maintain dual therapy (Sulf/Pio) as comparator to Liraglutide
- Where
- 2 sites in United Kingdom
- Volunteers
- 99 people
- Sponsor
- University of Leicester
Squamous Cell Carcinoma of the Skin
Preventing Squamous Cell Skin Cancer
This study is proposed based on our work showing that the diabetes drug Pioglitazone strongly inhibits growth of tissue cultured squamous cell carcinoma (SCC) of the skin.
- Trial name
- NCT02347813
- Testing
- Pioglitazone
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Type 2 Diabetes, Hypertension
Effect of Pioglitazone on Cardiovascular Outcome on Higashi-Saitama Trial in Patients With Type 2 Diabetes
We want to investigate the effects of pioglitazone on cardiovascular events in Japanese patients with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Hypertension, Dyslipidemia, Diabetic Nephropathy
- Trial name
- NCT00419484
- Testing
- pioglitazone
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Dokkyo Medical University
Diabetes Mellitus, Type II
Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus (0431-020)(COMPLETED)
The purpose of this study is to determine the safety and efficacy of an investigational drug in patients with type 2 diabetes mellitus.
- Trial name
- NCT00086515
- Testing
- Sitagliptin (MK0431), Metformin, Pioglitazone
- Volunteers
- 701 people
- Sponsor
- Merck Sharp & Dohme LLC
Uncontrolled Type 2 Diabetes Mellitus
Sitagliptin vs. Pioglitazone as add-on Treatments in Patients With Type 2 Diabetes Uncontrolled on the Full-dose Metformin Plus Sulfonylurea
This study has been designed to investigate the comparative effects of sitagliptin vs. pioglitazone as add-on treatments in patients with type 2 diabetes who were uncontrolled on the full-dose of metformin and sulfonylurea
- Trial name
- NCT03125694
- Testing
- Sitagliptin 100mg, Pioglitazone 30 mg
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Tehran University of Medical Sciences
Type 2 Diabetes Mellitus
A Placebo Controlled Safety and Efficacy Study of MSDC-0160 in Type 2 Diabetes With Active Comparator
The purpose of this study is to determine if MSDC-0160 is effective in the treatment of Type 2 diabetes.
- Trial name
- NCT00760578
- Testing
- Pioglitazone, MSDC-0160 90 mg, MSDC-0160 220 mg
- Where
- 8 sites in United States
- Volunteers
- 86 people
- Sponsor
- Metabolic Solutions Development Company
Diabetes Mellitus, Type 2
Safety and Efficacy of Linagliptin (BI 1356) as Monotherapy or in Combination in Type 2 DM
The objective of the current study is to investigate the safety and tolerability of BI 1356 (5 mg / once daily) given for 78 weeks in different modalities of treatment.
- Trial name
- NCT00736099
- Testing
- linagliptine 5 mg, linagliptine 5 mg and pioglitazone 30 mg
- Where
- 232 sites in United States, Argentina and 30 more
- Volunteers
- 2,122 people
- Sponsor
- Boehringer Ingelheim
Polycystic Ovary Syndrome
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycystic ovary syndrome of all body weights.
- Trial name
- NCT00694759
- Testing
- pioglitazone, metformin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity, Overweight With Indications for Weight Loss
Optimizing Body Composition for Function in Older Adults
The purpose of this pilot study is to compare two strategies intended to improve the health of overweight older adults by improving body composition.
- Trial name
- NCT00315146
- Testing
- Pioglitazone, Resistance exercise training to maximize muscle power, Hypocaloric diet
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy
Pharmacokinetic Drug Interaction Between LC15-0444 and Pioglitazone After Oral Administration in Healthy Male Subjects
The objective of the study is to investigate the drug interaction between LC15-0444 and pioglitazone by comparing the safety, tolerability and pharmacokinetics of LC15-0444 and pioglitazone are administered concomitantly and each…
- Trial name
- NCT01001013
- Testing
- LC15-0444, Pioglitazone
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Polycystic Ovary Syndrome, Infertility
Ovulation Induction in Clomiphene Citrate Resistant PCO Women
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia contributes to chronic anovulation commonly encountered in women with PCOS. The first choice therapy is clomiphene citrate (CC).
- Trial name
- NCT02341703
- Testing
- letrozole-metformin, letrozole-metformin-pioglitazone, transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome
Pioglitazone Treatment in Polycystic Ovary Syndrome
In this study, the investigators wish to investigate how pioglitazone treatment effects hirsute women. Hirsute women are often overweight and have an increased amount of male sex hormone in their blood.
- Trial name
- NCT00145340
- Testing
- pioglitazone
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital